OPIOID-RELATED DISORDERS

This early-stage study tests whether adding lacosamide, a seizure medication, to standard opioid therapy is safe and tolerable for people with chronic pancreatitis and ongoing abdominal pain. About 24 adults who have been on opioids for at least 4 weeks will take lacosamide for 7…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who have been taking opioids for at least three months. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. Abou…

This study tests whether psilocybin (the active ingredient in magic mushrooms) combined with therapy can safely ease severe pain in people with advanced cancer that doesn't respond to opioids. Fifteen adults with advanced cancer and persistent pain will receive the treatment and …

This study aims to understand how people with opioid-use disorder learn and make decisions compared to those without the disorder. Participants will complete a computer task where shapes are paired with food odors, and their responses and breathing will be monitored. The goal is …

This study uses brain scans to understand why some people relapse to opioid use during treatment. Researchers at Yale will follow 240 adults recently started on methadone or buprenorphine, tracking their brain connectivity and drug use for six months. The goal is to identify patt…