OPIOID-RELATED DISORDERS

This study tests whether a smartphone app can help people with opioid use disorder stay off drugs. Participants use the app to submit videos of themselves taking saliva drug tests, get reminders and rewards, and access live support. The study involves 250 adults in the US who are…

This study tests whether a smartphone app can help people on medication for opioid use disorder avoid relapse. The app tracks cravings and uses location data to offer support when users enter high-risk areas. About 336 adults will use the app for 6 months, with some also having b…

This study is testing whether special vending machines (kiosks) that provide clean syringes and other harm reduction supplies can help lower the risk of HIV, hepatitis C, and drug overdoses in rural Appalachian Kentucky. About 752 adults who use drugs will take part. The goal is …

This study tests a program where pharmacists provide brief counseling and medication management to adults at risk of misusing prescription opioids. The goal is to prevent opioid use disorder and overdose. 350 participants from 14 community pharmacies are taking part.

This study tests a treatment called cryoneurolysis, which freezes nerves around the knee before total knee replacement surgery. The goal is to reduce pain and the need for strong painkillers (opioids) after surgery. About 100 adults with knee osteoarthritis will be randomly assig…

This study looks at a new computer tool that helps doctors know which patients are at high risk for an opioid overdose. The tool works inside the hospital's electronic health record system and sends an alert when a doctor prescribes an opioid. Researchers are checking if the tool…

This study works with overdose fatality review teams in Indiana to help them use a new data dashboard instead of just reviewing individual cases. The goal is to spot patterns and opportunities to connect people at risk with treatment. About 400 team members and leaders will take …

This study looks at whether teaching primary care doctors about safe opioid prescribing can lower the number of risky prescriptions. Researchers will track changes in how much and what types of opioids are prescribed at 52 clinics. The goal is to reduce the chance of addiction an…

This study looks at whether opioid use disorder and non-fatal overdoses cause a harmful protein called tau to build up in the brain. Researchers will scan the brains of 60 adults—some with opioid use disorder and a past overdose, some with opioid use disorder but no overdose, and…