Opioid-related disorders

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This study tests a program where pharmacists provide weekly phone coaching to adults who may be misusing opioid medications. The goal is to reduce risky opioid use and prevent addiction. 350 participants across 14 pharmacies are taking part in this randomized trial.

This study tests whether a smartphone app can help people on medication for opioid use disorder stay drug-free. The app tracks location and sends alerts when users enter high-risk areas. Researchers will also use brain scans to understand why some people do better than others. Th…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This study tests whether freezing specific nerves around the knee before total knee replacement surgery can reduce pain and the need for opioids afterward. One hundred adults scheduled for knee replacement will either receive the nerve-freezing treatment or a sham procedure. The …

This study tests a machine-learning tool that gives doctors a pop-up alert when they prescribe opioids to a patient at high risk of overdose. The alert explains why the patient is at risk and suggests safer options, like prescribing naloxone or referring to pain therapy. Research…

This study tests whether giving doctors brief education and feedback on their opioid prescribing habits leads to safer prescribing. About 52 primary care clinics are involved. The goal is to reduce inappropriate opioid use and lower the risk of addiction.

This study aims to improve how overdose fatality review teams work by giving them a data dashboard and training. Instead of reviewing just one or two cases at a time, teams will use near real-time data to spot patterns and make better recommendations. About 400 team members and l…