Brain zaps could help smokers kick the habit for good
NCT ID NCT05152810
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether transcranial magnetic stimulation (TMS) can help smokers quit by reducing cravings and preventing relapse. 88 adults who had failed previous quit attempts received daily TMS sessions for a week, followed by maintenance sessions. The goal was to see if this approach could help them stay smoke-free for up to 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- transcranial magnetic stimulation (TMS)
- What this could lead to
- If this works, it could offer a new, non-drug option to help people quit smoking by reducing cravings and preventing relapse.
- What could go wrong
- This is a small pilot study, so results may not apply to everyone. Previous similar studies showed benefits faded after stimulation stopped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
88 people
The number who actually took part.
- Started
-
Jan 2022
- Finished
-
Nov 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patient who has given oral consent * Adult patient * Patient who wants to quit smoking * Patient with a smoking disorder (DSM-5 criteria) * Patient with at least 1 previous failed smoking cessation treatment with recommended medications (nicotine, vareniciline, or bupropion) Exclusion Criteria: * Patient not affiliated to the national health insurance system * Patient subject to a measure of legal protection (curatorship, guardianship) * Pregnant or breast-feeding woman * Patient of childbearing age with a positive pregnancy test at inclusion * Patients of legal age who are unable to express their consent * Patient abstinent in the previous 3 months * Patient with a substance use disorder (DSM-5 criteria) * Patient with a contraindication to TMS: personal history of seizure, pacemaker, neurosurgical clips, carotid or aortic clips, heart valves, hearing aids, ventricular shunt valves, sutures with wires or staples, foreign bodies in the eye, shrapnel, other prosthesis or cephalic ferromagnetic material * Patient employed in the addictology department of the CHU of Dijon (department of the principal investigator) * Patient with severe depression, defined by a score greater than or equal to 24 on the Hamilton Depression Rating Scale (HDRS) * Patient having had a recent change (\< 1 month) in the prescription of a psychotropic treatment * Patients with severe and/or chronic psychiatric disorders, including schizophrenia, paranoia, and bipolar disorder types I and II * Patients with severe heart, kidney, liver or lung failure or other conditions that could compromise the patient's participation in the study in the opinion of the physician * Patient concurrently participating in another therapeutic trial * Patient who has already participated in a transcranial magnetic stimulation session
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Smoking cessation are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Chu Dijon Bourgogne
Dijon, 21000, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Texts and wearables team up to help latinos quit smoking and get moving
- Can an AI chatbot help cancer patients kick the habit?
- Does the clock matter? scientists randomize when Quit-Smoking chatbots ping you
- Can a WhatsApp message help smokers quit?
- Can a brain scan tailor TMS to quiet cigarette cravings?
- Practice quitting: a new way to help smokers who Aren't ready to stop?