Can smartphone apps help fight addiction in primary care? large study tests new approach.
NCT ID NCT05160233
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at the best ways to bring FDA-approved digital treatments (reSET and reSET-O) for opioid and other substance use disorders into primary care clinics. Over 18,000 adults who screened positive for substance use took part. Researchers tested whether health coaching or practice coaching helped clinics use these digital tools more effectively.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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18,430 people
The number who actually took part.
- Started
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Dec 2021
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Patient Inclusion Criteria: * Had a primary care visit in a participating clinic during the active implementation period or sustainment period * Screened positive for substance use on the day of the visit or in the prior year * Adult aged 18 years or older at time of visit Clinic Inclusion Criteria: \- At least 1 clinician trained in the use of reSET/reSET-O Patient Exclusion Criteria: \- Patients who have requested through their health system to opt out of research Clinic Exclusion Criteria: \- Previously participated in a pilot implementation of reSET/reSET-O
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Kaiser Permanente Washington
Seattle, Washington, 98101, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new drug calm the storm of opioid withdrawal?
- Can Brain-Training games rewire the mind to fight alcohol addiction?
- Can a Stress-Hormone blocker take the edge off alcohol?
- Can coaching turn rural clinics into One-Stop shops for addiction and infectious disease care?
- Can MDMA plus therapy help veterans fight both PTSD and alcohol addiction?