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Cannabis study reveals hidden brain risks in asian users

NCT ID NCT04373525

Knowledge-focused Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study from the University of Hong Kong looked at 110 cannabis users aged 16-60 to see how their thinking skills change over time and if genes play a role. Participants took memory and thinking tests and gave blood for genetic analysis. The goal is to understand long-term brain effects in Asian users, who have been understudied.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how cannabis harms memory and thinking in Asian users, and identify genetic risks for worse outcomes.
What could go wrong
This is an observational study with only 110 participants, so results may not apply to everyone. It does not test a treatment, so no direct health benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

110 people

The number who actually took part.

Started

Nov 2020

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

16-60 years old cannabis users

Ages

16 to 60 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 16 - 60 years old at the time of enrolment * Able to read and communicate in English and/or Chinese * Able to give informed consent * Using cannabis or marijuana as the primary psychoactive substance of abuse * Repeated and Active cannabis users as defined by Structured Clinical Interview for DSM-5 Disorders Exclusion Criteria: * Age \<16 years old * Unable to read English or Chinese * Unable to give informed consent * Had been diagnosed with other Substance Related Disorders, except for Tobacco Use Disorders due to the known frequent comorbid use for cannabis users (12) * Currently taking regular prescribed psychiatric medications, including antipsychotics, antidepressants, mood stabilizers, anti-epileptics, benzodiazepines, hypnotics, and anti-cholinergic medications. * Had been diagnosed with DSM-5 disorders, other than Cannabis Use and related disorders

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Conditions

The condition(s) this trial relates to.

cannabis dependence Cognition Disorders cognitive disorder inherited disease susceptibility

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cannabis use Genetic predisposition Neurocognitive dysfunction

Contacts and locations

Locations

  • Queen Mary Hospital

    Hong Kong, 000000, Hong Kong

More trials for these conditions

Other studies related to the condition(s) this trial covers.