Could a single pill before surgery cut opioid use after kidney stone treatment?
NCT ID NCT04122196
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether giving a single dose of pregabalin (Lyrica) before ureteroscopy—a surgery for kidney stones that often leaves a temporary stent in the ureter—can reduce pain and the need for opioid painkillers afterward. 118 adults were randomly assigned to receive either pregabalin or a placebo about an hour before surgery. Researchers then measured pain scores and how much opioid medication patients used during recovery. The goal is to find a safer, non-narcotic way to manage post-surgery discomfort.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- pregabalin (Lyrica)
- What this could lead to
- If it works, this could offer a simple way to reduce pain and the need for opioid painkillers after kidney stone surgery.
- What could go wrong
- This is a small, completed Phase 2/3 trial. The benefit may be modest, and pregabalin can cause side effects like dizziness or drowsiness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
118 people
The number who actually took part.
- Started
-
Jun 2020
- Finished
-
Jul 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Subject Inclusion: * Age \>= 18 years * Subject Population Undergoing elective ureteroscopy with stent placement at University of Missouri Hospital and affiliated facilities Subject Exclusion: * Renal insufficiency (eGFR \< 60 mL/minute/1.73 m2) * Chronic indwelling ureteral stent (\>30 days in the previous year) * Chronic opioid use * History of opioid abuse * Chronic gabapentinoid use * History of gabapentinoid abuse * Plan for inpatient hospitalization * Pregnancy * Inability of the patient to consent for themselves in English * Allergy to gabapentinoid * Liver failure or hepatic dysfunction
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Missouri-Columbia
Columbia, Missouri, 65212, United States
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