Nerve block may ease opioid withdrawal in small pilot study
NCT ID NCT04946656
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether blocking a nerve cluster called the SPG can reduce withdrawal symptoms in people with opioid use disorder. Only 3 people took part, and the goal was to see if the approach is safe and worth studying further. It did not provide addiction treatment or medication.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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3 people
The number who actually took part.
- Started
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Feb 2023
- Finished
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Sep 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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22 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Opioid Use Disorder, moderate to severe * Ages 22 to 50 * Lives in New York City, able to travel for visits * Willing to be admitted to an inpatient unit Exclusion Criteria: * Medical disorder, for who study participation could be deleterious (neurologic, cardiac, renal or infectious disease * Hypertension: BP \> 150/100 * Elevated liver function tests (AST, ALT) \> 3x normal * Having a painful medical illness for which opioids are needed (including upcoming surgery).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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1051 Riverside Drive
New York, New York, 10032, United States
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Other studies related to the condition(s) this trial covers.
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