New York State Psychiatric Institute

This study tests whether clozapine, an antipsychotic medication, can reduce violent acts in people with schizophrenia or schizoaffective disorder who have a recent history of violence. Researchers will compare clozapine to standard antipsychotic treatment in 280 participants over…

This study aims to find out which parts of a relapse prevention treatment work best for people with anorexia nervosa after they leave the hospital. About 60 adults who have regained a healthy weight will take part. Researchers will track weight changes, eating habits, and motivat…

This study tests a vaccine that helps the body produce antibodies against oxycodone, a commonly abused prescription opioid. The goal is to reduce the drug's ability to reach the brain and lower its pleasurable effects. The trial involves 45 adults with opioid use disorder and foc…

This study tests whether adding buprenorphine-naloxone to the standard naltrexone shot helps people with opioid use disorder stay in treatment longer and reduce cravings. About 180 adults aged 18–65 will receive either the combo or a placebo for 24 weeks. The goal is to see if th…

This study compares two types of employment services for adults with obsessive-compulsive disorder (OCD) who are unemployed and want to work. All 40 participants will receive up to 12 sessions of cognitive behavioral therapy (CBT), and half will also get Individual Placement and …

This study tests a computer-based therapy for adults with social anxiety disorder. Researchers want to see if it reduces anxiety and improves quality of life. About 80 people aged 18 to 60 with social anxiety will participate. The therapy is designed to be a new, accessible treat…

This study tests whether a drug called pimavanserin can reduce rigid, repetitive behaviors in people with autism. About 30 adolescents and adults aged 12 to 40 will receive either the drug or a placebo, then switch. The goal is to see if it improves flexibility and reduces compul…

This study uses a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to explore how it changes food choices and brain activity in people with anorexia nervosa. Researchers will give a single session of rTMS to 72 women aged 18-30 w…

This study looks at whether giving mothers in Brazil an extra $40 per month (compared to just $2) can protect their children's brain development and mental health. About 450 children aged 7-10 from low-income families will be followed for 2 years. Researchers will measure stress,…