New York State Psychiatric Institute

This study tests whether a brain stimulation technique called deep rTMS can help people with alcohol use disorder drink less. Participants receive either real or sham rTMS over 3 weeks while staying in the hospital. Researchers measure changes in alcohol self-administration and c…

This study tests whether D-serine, a natural brain chemical, can improve learning and memory in people with schizophrenia or schizoaffective disorder. 60 adults will take D-serine for 16 weeks while doing auditory exercises. The goal is to see if it helps the brain adapt and lear…

This study aims to see if mobile phone messages can help teens in Uganda prevent HIV and address related issues like mental health and alcohol use. Researchers will adapt an existing text and voice system to include HIV prevention info and mental health screening. About 200 adole…

This study tests a new computer therapy that uses eye-tracking to help people with social anxiety disorder. About 60 adults aged 18 to 60 will try this treatment to see if it reduces their fear and avoidance of social situations. The goal is to find a new, non-drug way to ease sy…

This study tests a new sublingual film (BXCL501) to reduce the unpleasant symptoms of opioid withdrawal, like anxiety, pain, and nausea. About 160 adults with opioid use disorder will receive BXCL501, a standard drug (lofexidine), or a placebo during a 7-day inpatient detox. The …

This study looks at whether the anti-inflammatory drug celecoxib (Celebrex) can help people with obsessive-compulsive disorder (OCD) who still have symptoms despite current medication. Researchers will use brain scans and blood tests to measure inflammation and see if it predicts…

This study aimed to see if a single injection of ketamine could quickly reduce suicidal thoughts in depressed patients visiting the emergency room. About 90 adults with severe depression and active suicidal thoughts were to receive either ketamine or a sedative called midazolam. …

This study is developing and testing a specially adapted form of therapy for transgender and gender non-conforming adults who have alcohol use disorder. The therapy is based on interpersonal psychotherapy and is designed to address unique life experiences that may affect drinking…

This study looks at how to improve opioid court programs in New York State. Researchers will work with court staff and treatment providers to help defendants quickly get medication for opioid use disorder. The goal is to see if these strategies increase treatment retention, reduc…

This study looks at whether air pollution exposure before birth is linked to ADHD risk in Puerto Rican children. Researchers will use brain scans (MRI) in 182 kids aged 6-11 to examine brain areas tied to attention. They also want to see if inflammation during pregnancy or sleep …

This study was designed to explore how cariprazine (Vraylar) might help people with bipolar depression by looking at its effect on a specific brain receptor (D3 dopamine). Participants would have taken cariprazine for six weeks and undergone PET scans to see how the drug works in…

This study aimed to adapt an opioid overdose education and naloxone distribution program for Black church members, including clergy, people with opioid use disorder, and their families. The goal was to reduce stigma and increase overdose reversal skills. However, the trial was wi…

This study tests a program where trained peer coaches help people with financial hardship and suicide risk learn money management skills, create a financial plan, and connect with community resources. The program includes group and one-on-one video sessions over several months. T…

This study involves 400 healthy adults aged 60-85 to test new computerized measures of thinking and daily function. Participants are randomly assigned to take either the new tests or standard tests over one year. The goal is to see if the new tests are better at detecting changes…

This study looks at whether adding cognitive remediation (computer-based brain exercises with group coaching) to standard care helps young people with early psychosis function better in daily life. About 117 participants from nine OnTrackNY programs will either get usual care or …

This study is creating a learning healthcare system for OnTrackNY, a program that provides coordinated specialty care to young people (ages 16-30) who have experienced early psychosis. Researchers will collect data from over 2,100 participants and gather feedback from patients, f…

This study looks at how using cannabis every day affects pain sensitivity, the risk of abuse, and natural pain-relieving chemicals in the body. About 100 regular cannabis users (ages 21-65) will stay in a hospital for 15 days and receive cannabis with different levels of THC and …

This study looks at how ketamine changes brain activity in 35 healthy volunteers. Participants will have two brain scans after receiving different doses of ketamine. The goal is to understand the brain processes linked to psychosis, not to treat any disease. The study is currentl…

This study looks at how ketamine changes brain activity in 120 healthy adults. Participants will get either a study drug or a placebo for 4 days, and have two brain scans to measure these changes. The goal is to understand brain chemicals linked to psychosis, not to treat any dis…

This study records brain activity from 170 healthy adults using EEG and MRI to understand how beta oscillations help form flexible neural ensembles. Participants perform simple perceptual tasks like detecting sounds or images while their brain waves are measured. The goal is to l…

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if ca…