New York State Psychiatric Institute

This study is testing a vaccine that may help people with opioid use disorder by training the body to block opioids from reaching the brain. The goal is to reduce cravings and prevent relapse. The trial involves 45 adults aged 18 to 59 and focuses on safety, immune response, and …

This study looks at how to best prevent relapse in people with anorexia nervosa after they leave the hospital. Researchers will test different parts of a treatment package to see which ones help patients maintain a healthy weight and change unhealthy habits. The goal is to find t…

This study tests whether adding buprenorphine-naloxone to the standard naltrexone shot helps people with opioid use disorder stay in treatment longer and reduce cravings. About 180 adults aged 18–65 will receive either the combo or a placebo for 24 weeks. The goal is to see if th…

This study tests whether clozapine, a medication for schizophrenia, can lower the risk of violent acts better than other antipsychotics. About 280 adults with schizophrenia or schizoaffective disorder who have been violent in the past six months will take either clozapine or thei…

This study tests a new computer-based therapy for people with social anxiety disorder. Researchers want to see if it reduces anxiety and improves quality of life. About 80 adults aged 18 to 60 with social anxiety will participate. The therapy is designed to be a convenient, at-ho…

This study tests whether a drug called pimavanserin can reduce rigid, repetitive behaviors in people with autism. About 30 adolescents and adults aged 12 to 40 will receive either the drug or a placebo, then switch. The goal is to see if it improves flexibility and reduces compul…

This study tests two ways to help adults with obsessive-compulsive disorder (OCD) find and keep jobs. All 40 participants will receive up to 12 sessions of a proven therapy called exposure and response prevention (a type of CBT). Half will also get extra job support (Individual P…

This study explores how a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) affects food choices in women with anorexia nervosa. Researchers will measure brain activity and eating behavior in 72 participants aged 18-30. The goal i…

This study looks at whether giving extra money to mothers in Brazil can help protect their children's brain development and mental health. About 450 families already receiving a small cash benefit will be randomly assigned to get either a high ($40/month) or low ($2/month) extra …