New York State Psychiatric Institute

This study tests whether D-serine, a natural brain chemical, can improve learning and memory in people with schizophrenia or schizoaffective disorder. 60 adults will take D-serine for 16 weeks while doing auditory exercises. The goal is to see if it helps the brain adapt and lear…

This study aims to see if mobile phone messages can help teens in Uganda prevent HIV and address related issues like mental health and alcohol use. Researchers will adapt an existing text and voice system to include HIV prevention info and mental health screening. About 200 adole…

This study explores whether a non-invasive brain stimulation technique called deep rTMS can help people with alcohol use disorder drink less. Researchers will target brain areas involved in memory and decision-making, which are often impaired in this condition. About 44 adults wi…

This study tests a new computer-based therapy that uses eye-tracking to help people with social anxiety disorder. The goal is to see if it reduces anxiety and is easy to use. About 60 adults aged 18 to 60 with social anxiety will participate.

This study aims to see if a single injection of ketamine can quickly reduce suicidal thoughts in people with depression who come to the emergency room. Participants will receive either ketamine or a sedative called midazolam, and their suicidal thoughts will be measured before an…

This study tests a new sublingual film (BXCL501) to reduce the unpleasant symptoms of opioid withdrawal, like anxiety, pain, and nausea. About 160 adults with opioid use disorder will receive either the new drug, a standard non-opioid medication (lofexidine), or a placebo during …

This study looks at whether brain scans and blood tests can show which people with obsessive-compulsive disorder (OCD) will get more relief from adding an anti-inflammatory drug (celecoxib) to their current medication. About 21 adults aged 18-55 with ongoing OCD symptoms despite …

This study tests a peer-led program for adults aged 18-64 in NYC who are struggling financially and thinking about suicide. The program teaches money management skills, helps create a financial plan, and connects participants to community resources like free counseling and housin…

This study is developing and testing the first culturally-adapted therapy for alcohol use disorder specifically for transgender and gender non-conforming adults. About 30 participants will receive a version of interpersonal psychotherapy adjusted to address unique life experience…

This study looks at how a low dose of ketamine changes brain activity in healthy volunteers. Researchers use brain scans and symptom checklists to understand brain chemicals linked to psychosis. The goal is to learn more about these brain processes, not to treat any disease. Abou…

This study aims to create a learning healthcare system for OnTrackNY, a program that provides coordinated specialty care to adolescents and young adults (ages 16-30) who have experienced early psychosis. The goal is to improve treatment by collecting data, engaging patients and f…

This study aimed to understand how the medication cariprazine (Vraylar) helps treat depression in people with bipolar disorder. Researchers planned to use PET brain scans to see how the drug affects a specific brain receptor (D3 dopamine). The study was withdrawn before any parti…

This study looks at how ketamine changes brain activity in 120 healthy adults. Participants will get either a study drug or a placebo for 4 days, and have two brain scans to measure these changes. The goal is to understand brain chemicals linked to psychosis, not to treat any dis…

This study records brain activity from 170 healthy adults using EEG and MRI to understand how beta oscillations help form flexible neural ensembles. Participants perform simple perceptual tasks like detecting sounds or images while their brain waves are measured. The goal is to l…

This study planned to train African-American church members—including clergy, people with opioid use disorder, and their families—on how to recognize and respond to an opioid overdose using naloxone. The goal was to reduce stigma and increase knowledge, but the study was withdraw…

This study looks at how air pollution exposure during pregnancy might increase a child's risk for ADHD. Researchers will use brain scans to examine possible causes, such as inflammation and sleep problems. The study involves 182 Puerto Rican children and their parents from an exi…

This study looks at whether adding cognitive remediation (a type of brain training) to standard care helps young people with early psychosis improve their daily functioning. About 117 participants from nine clinics will either get usual care or usual care plus cognitive remediati…

This study looks at how using cannabis every day for two weeks changes pain sensitivity, the risk of abuse, and natural cannabis-like chemicals in the body. One hundred healthy adults who already use cannabis nearly daily will stay in a hospital for 15 days and receive cannabis w…

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if ca…

This study looks at how to better connect people in opioid court with medication-assisted treatment. Researchers will test strategies to help more defendants stay in treatment, graduate from court, and avoid future opioid use. Over 3,400 court staff and treatment providers will t…

This study aims to develop better tools for measuring thinking skills and daily function in healthy older adults. Researchers will compare new computerized tests with standard ones over one year. The goal is to find measures that are more accurate and less affected by practice, w…