Cannabis study probes pain tolerance and addiction risk in daily users

NCT ID NCT05563948

Terminated Knowledge-focused Sponsor: New York State Psychiatric Institute Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at what happens when people who use cannabis regularly take it daily for two weeks. Researchers will measure pain sensitivity, feelings of a 'good drug effect,' and natural cannabis-like chemicals in the blood. The goal is to understand if daily use changes pain response and abuse potential, and whether different THC-to-CBD ratios matter.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cannabis (vaporized, with varying THC and CBD ratios)
What this could lead to: If successful, this could clarify whether daily cannabis use leads to tolerance or increased pain sensitivity, helping guide medical cannabis recommendations for pain management.
What could go wrong: This is a small, early-phase study in healthy regular users, not patients with chronic pain. Results may not apply to medical populations, and the study is currently suspended.

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Conditions

The condition(s) this trial relates to.

cannabis dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANNABIS

Contacts and locations

Locations

New York State Psychiatric Institute

New York, New York, 10032, United States

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