New York State Psychiatric Institute

This study tests if a non-invasive brain stimulation technique called rTMS, given before cognitive-behavioral therapy, can help adults with cocaine use disorder stop using cocaine. Thirty participants will receive either real or placebo rTMS daily for 3 weeks, followed by weekly …

This study tests whether giving buprenorphine (a medication for opioid addiction) through telemedicine works as well as getting it in person. About 50 adults with opioid use disorder will be randomly assigned to either remote or in-person care. The main goal is to see how long pe…

This study tests a mindfulness program called MINDS-UP to prevent substance use in children aged 10 to 14. About 45 kids will either take mindfulness classes plus a sports-based prevention program, or just the sports program alone. Researchers will check if the program is easy to…

This study tests whether two sleep treatments—cognitive behavioral therapy for insomnia and gentle sound stimulation during sleep—can improve memory and daily thinking skills in older adults with mild cognitive impairment and sleep problems. Fifty participants aged 60-85 will be …

This study tests a shared decision-making tool for antipsychotic medications in 120 young adults (ages 18-30) with early psychosis. The goal is to see if the tool helps patients feel more involved in their care and more likely to stick with treatment. Participants will use the de…

This study uses PET and MRI brain scans to look at dopamine, a brain chemical linked to psychosis, in 115 people aged 18–30 who are at high risk. Participants will have scans and be followed every 3 months for up to 2 years to see if they develop psychosis. The goal is to underst…

This study tests whether brief, 1-2 minute videos featuring real parents sharing their experiences can reduce stigma and improve treatment-seeking among parents of children aged 6-18 with depression, ADHD, or substance use problems. About 1,600 parents aged 25-50 will be recruite…

This study will use special brain scans (PET/MRI) to see how the drug Cobenfy changes dopamine activity in people with schizophrenia. Twelve adults who are not currently taking antipsychotics will take Cobenfy for 5 weeks and get scans before and after. The goal is to understand …

This study looks at how stress and suicidal thoughts are linked in people with major depressive disorder, and how ketamine might help. Researchers will use smartphone tracking and brain scans to understand the brain pathways involved. The goal is to learn more about the biology b…