Can a common schizophrenia drug curb violent acts? new trial aims to find out
NCT ID NCT05208190
First seen Jan 07, 2026 · Last updated Jun 21, 2026 · Updated 26 times
Summary
This study tests whether clozapine, an antipsychotic medication, can reduce violent acts in people with schizophrenia or schizoaffective disorder who have a recent history of violence. Researchers will compare clozapine to standard antipsychotic treatment in 280 participants over 24 weeks. The goal is to see if clozapine is more effective at preventing violence in real-world settings.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Augusta University Research Institute, Inc.
RECRUITINGAugusta, Georgia, 30912, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Manhattan Psychiatric Center
RECRUITINGNew York, New York, 10035, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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NYU Langone Medical Center
RECRUITINGNew York, New York, 10016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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New York State Psychiatric Institute
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact
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University of California, Los Angeles
RECRUITINGLos Angeles, California, 90024, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland School of Medicine
RECRUITINGBaltimore, Maryland, 21201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Clozapine (a medication also known as Clozaril)
What this could lead to
If it works, this could provide a more effective way to reduce violence in people with schizophrenia, improving safety and quality of life.
What could go wrong
This is a Phase 4 open-label trial, so results may be biased. Clozapine has serious side effects, including a need for regular blood monitoring. The study is still recruiting, so outcomes are uncertain.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.