Home delivery of addiction meds may keep ex-prisoners clean
NCT ID NCT02867124
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 240 prisoners with opioid addiction to see if getting a long-acting naltrexone shot at home after release works better than going to a clinic. Participants got one shot in prison and six monthly shots either at a clinic or at their home. The goal was to see if home treatment helps them stay off opioids, avoid relapse, and reduce re-arrests.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 240 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2017
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult male or female inmate at MTC, BPRU, JPRU, BCCC, or MCIW and be eligible for release within 30 days * History of opiate disorder \[meeting DSM-V criteria of dependence at the time of incarceration\] * Suitability for XR-NTX treatment as determined by medical evaluation * Currently opioid-free by history, with negative urine for all opioids and no signs of opiate withdrawal * Willingness to enroll in XR-NTX treatment in prison \[not currently in or planning to pursue agonist (methadone, buprenorphine) treatment at release\] * Planning to live in Baltimore City or County. * Inmates not meeting the opioid-dependence criterion will be eligible if they were treated in an opioid agonist treatment program during the year before incarceration Exclusion Criteria: * Liver function test levels greater than three times normal * Active medical illness that may make participation hazardous (e.g., unstable diabetes, heart disease). Adequately treated medical conditions are acceptable * Untreated psychiatric disorder that may make participation hazardous (e.g., untreated psychosis, bipolar disorder with mania). Adequately treated psychiatric disorders and appropriate psychotropic medications will be allowed * History of allergic reaction to XR-NTX * Current chronic pain diagnosis for which opioids are prescribed * Creatinine above normal limits * Pregnancy (for women) * Breast-feeding (for women) * Suicidal ideation (within the past 6-months) * Body Mass Index (BMI) \> 40 * Unadjudicated charges that may result in transfer to another facility and/or additional prison time.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Maryland Department of Public Safety and Correctional Services
Towson, Maryland, 21286, United States
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Other studies related to the condition(s) this trial covers.