Cannabis and HIV: brain health under the microscope

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Participants must be 18-70 years old. 2. PLWH must have documented HIV infection for approximately 1 year, be on a cART regimen for approximately ≥3 months, and be virally well-controlled (\< 200 copies/mL). 3. HIV- controls must have confirmed HIV- serostatus. 4. Participants must complete at least 9 years of education. 5. Participants must be able to provide informed consent. 6. Female participants must have a negative pregnancy test or written documentation of tubal ligation, hysterectomy, post-menopausal status, etc. and cannot be breastfeeding. 7. Participants should have no contraindications to an MRI scan. 8. Participants should be willing to have cannabis use history confirmed via clinical interview and urine analysis . 9. All inclusion criteria at PI discretion. Exclusion Criteria: 1. History of neurological disorder (e.g., stroke, head injury with loss of consciousness for \>5 minutes, developmental learning disability, etc.). 2. Uncontrolled major affective disorder; history of bipolar disorder or schizophrenia. Major depression controlled with no hospitalizations or suicidal ideation in the past year is allowed. 3. Current substance use disorder (SUD) as defined by DSM-5 criteria besides cannabis use disorder (CUD) (though a past SUD \> 1 year before the time of study enrolment will be allowed). 4. currently prescribed anti-coagulants (only exclusionary if participant will engage in optional LP). 5. an allergy to lidocaine or similar anesthetic (only exclusionary if participant will engage in optional LP). 6. a history of a bleeding disorder (only exclusionary if participant will engage in optional LP). 7. claustrophobia or a pacemaker that would prevent magnetic resonance imaging (MRI) scanning. 8. all exclusion criteria at PI discretion.