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Cure My Disease

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New study tests smarter smoking cessation strategies

NCT ID NCT04188873

Disease control Sponsor: University of Wisconsin, Madison Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested different ways to help daily smokers quit by comparing two medications (varenicline and nicotine patches/lozenges), how long to take them before quitting, how long to continue after quitting, and the level of counseling. Over 500 smokers from primary care participated. The goal was to find the most effective and cost-efficient treatment plan to achieve long-term abstinence.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
varenicline and nicotine replacement therapy (patch and lozenge)
What this could lead to
If successful, this could identify the most effective combination of medication and counseling to help smokers quit long-term.
What could go wrong
This is a completed Phase 4 trial, so results are available but may not apply to all smokers. Side effects from medications are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

538 people

The number who actually took part.

Started

Dec 2020

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Smoking \>4 cigarettes/day for the previous 6 months * Able to read, write, and speak English * If currently using nicotine replacement therapy (NRT), agreeing to use only study medication for the duration of the study * Medically eligible to use study medications * If the participant is a woman of childbearing potential, using an approved method of birth control during treatment Exclusion Criteria: * Currently taking bupropion or varenicline * Suicidal ideation in the last 12 months or any suicide attempts in the past 10 years

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Conditions

The condition(s) this trial relates to.

nicotine dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Nicotine dependence

Contacts and locations

Locations

  • UW Center for Tobacco Research and Intervention

    Milwaukee, Wisconsin, 53233, United States

  • University of Wisconsin Center for Tobacco Research and Intervention

    Madison, Wisconsin, 53711, United States

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