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New study tests smarter smoking cessation strategies

NCT ID NCT04188873

First seen Jun 23, 2026

Summary

This study tested different ways to help daily smokers quit by comparing two medications (varenicline and nicotine patches/lozenges), how long to take them before quitting, how long to continue after quitting, and the level of counseling. Over 500 smokers from primary care participated. The goal was to find the most effective and cost-efficient treatment plan to achieve long-term abstinence.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • UW Center for Tobacco Research and Intervention

    Milwaukee, Wisconsin, 53233, United States

  • University of Wisconsin Center for Tobacco Research and Intervention

    Madison, Wisconsin, 53711, United States

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

varenicline and nicotine replacement therapy (patch and lozenge)

What this could lead to

If successful, this could identify the most effective combination of medication and counseling to help smokers quit long-term.

What could go wrong

This is a completed Phase 4 trial, so results are available but may not apply to all smokers. Side effects from medications are possible.

Conditions

The condition(s) this trial relates to.

Tobacco Use Disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.