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New behavioral therapy shows promise for smoking cessation in HIV patients

NCT ID NCT04532970

Symptom relief Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new type of counseling called behavioral activation problem solving (BAPS) against standard smoking cessation counseling for people with HIV in Botswana. 651 participants were split into two groups to see which approach helped more people quit smoking. The goal was to compare quit rates at 10 weeks and 26 weeks after starting treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
behavioral therapy (behavioral activation problem solving counseling)
What this could lead to
If it works, this could offer a more effective way to help people with HIV quit smoking, improving their overall health.
What could go wrong
This is a completed study, but results may not apply to all populations. Behavioral interventions can vary in effectiveness from person to person.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

651 people

The number who actually took part.

Started

May 2021

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * \>18 years old * Smoking cigarettes daily for the past 30 days * HIV+ with HIV viral load of \<1000 copies/mL, obtained within the 6 months prior to enrollment * Receiving HIV care at Infectious Diseases Care Clinics (IDCCs) in and around Gaborone * Able to communicate in English OR Setswana and provide written informed consent * Planning on residing in the geographic area for at least the next 7 months Exclusion Criteria: * Cognitive deficits that impair their ability to provide informed consent * Current untreated and unstable diagnosis of alcohol dependence (if past use and stable for \>30 days, eligible) * Psychosis * Use of chewing tobacco, snuff or snus * Recent , current, or planned use (next 7 months) of nicotine substitutes or smoking cessation treatments

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Conditions

The condition(s) this trial relates to.

HIV infectious disease nicotine dependence Smoking Smoking Cessation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV infections Smoking Smoking cessation

Contacts and locations

Locations

  • University of Botswana

    Gaborone, Botswana

More trials for these conditions

Other studies related to the condition(s) this trial covers.