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Can E-Cigarettes help smokers quit? new study tests wattage levels

NCT ID NCT03113136

Disease control Sponsor: Ohio State University Comprehensive Cancer Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether switching from regular cigarettes to either low or high wattage e-cigarettes changes smoking behavior and reduces exposure to harmful chemicals. 372 daily smokers who were not planning to quit were given e-cigarettes to use freely for 12 weeks, then checked at 6 and 12 months. The goal was to see if they would stop smoking regular cigarettes and how their bodies responded to the switch.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
e-cigarette devices (low wattage and high wattage)
What this could lead to
If switching to e-cigarettes helps smokers quit or reduce toxic exposure, this could point toward a less harmful alternative for people who cannot stop smoking.
What could go wrong
This is a completed study, but e-cigarettes still deliver nicotine and may have their own health risks. The results may not apply to all smokers, and long-term effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

372 people

The number who actually took part.

Started

Jun 2017

Finished

Jan 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. smoke ≥5 cigarettes per day for the past year; 2. no quit attempt in the prior 3 months and no plan to quit in the next 3 months; 3. read, write, and speak in English; 4. report at least minimal interest in switching to an alternative product (\> "not at all" on a Likert scale); 5. never purchased or regularly used a tank system, mechanical mod, or advanced personal vaporizer EC, though previous use of cig-a-like devices will be allowed but not in the last 3 months; 6. plan to live in the local area for next year; and 7. have reliable means of transport. - Exclusion Criteria: 1. \<18 years old; 2. unstable or significant medical condition such as respiratory, kidney, or liver disease that could potentially affect biomarker data; 3. unstable or significant psychiatric conditions (past and stable conditions will be allowed); 4. history of cardiac event or distress within the past 3 months; and 5. currently pregnant, planning to become pregnant, or breastfeeding (n.b: pregnancy status will continue to be evaluated throughout the study at each visit). \-

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking nicotine dependence poisoning Tobacco Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Exposure to toxic agent Nicotine dependence Smoking, cigarette Smoking, tobacco

Contacts and locations

Locations

  • The Ohio State University Comprehensive Cancer Center

    Columbus, Ohio, 43214, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.