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Can spit reveal how smoking fuels gum disease?

NCT ID NCT07764549

Knowledge-focused Sponsor: Zehra Hasgül Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This study looks at whether smoking and advanced gum disease (Stage III periodontitis) are linked to changes in three saliva markers: TNF-α, FoxO-1, and SIRT-1, which are involved in inflammation and stress responses. Researchers will compare saliva samples from 80 adults divided into four groups: healthy non-smokers, non-smokers with gum disease, healthy smokers, and smokers with gum disease. The goal is to understand how smoking and gum disease together affect the body's inflammatory pathways, which could inform future prevention and treatment approaches.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Salivary biomarker analysis (ELISA) measuring TNF-α, FoxO-1, and SIRT-1 levels
What this could lead to
If links are found, saliva tests might one day help spot gum disease risk or guide prevention and treatment strategies.
What could go wrong
This is a small observational study, so it can't prove cause and effect. Results may not apply to everyone, and the markers might not be reliable indicators.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

80 people

The number who actually took part.

Started

Oct 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Systemically healthy adults aged ≥18 years recruited from the Department of Periodontology, Faculty of Dentistry, İstanbul Medipol University, stratified into four groups (n=20 each) based on periodontal status (healthy vs. Stage III periodontitis) and smoking status (smoker vs. non-smoker, verified by salivary cotinine concentration).

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 18 years or older * At least 16 permanent teeth, excluding third molars * Not receiving orthodontic treatment * No systemic condition known to affect periodontal health Exclusion Criteria: * Pregnant or breastfeeding * Diabetes mellitus, rheumatoid arthritis, hypertension, or another systemic disease that could influence periodontal tissues * Periodontal treatment within the previous six months * Use of antibiotics or anti-inflammatory medications within the previous six months * Any local or systemic condition that could affect salivary biomarker concentrations

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking Inflammation periodontitis Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Periodontitis (stage 3) Smoking ( cigarette)

Contacts and locations

Locations

  • İstanbul Medipol University, Faculty of Dentistry, Department of Periodontology

    Istanbul, Turkey (Türkiye)

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