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Sweet vs. cool: do men and women react differently to E-Cig flavors?

NCT ID NCT05432830

Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study at Yale University looked at how 66 adult smokers (ages 21-44) perceive sweet, cooling, and unflavored e-cigarette liquids. Participants tried each flavor and rated its appeal, sensory effects, and how much they wanted it compared to money. The goal was to see if men and women respond differently to these flavors, which could inform future smoking reduction strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
E-liquid with 36 mg/ml nicotine in sweet, cooling, or unflavored flavors
What this could lead to
If successful, this research could help tailor e-cigarette flavors to reduce smoking in a sex-specific way.
What could go wrong
This is a small, completed observational study with only 66 participants, so findings may not apply broadly. It does not test a treatment or health outcome.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

66 people

The number who actually took part.

Started

Apr 2024

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 44 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 21-44 years old * Able to read/write * Current cigarette smoking * Recent E-cig Exposure (\>/= 10 uses in past 6 mo.) * Urine cot \>200ng/ml * Willing to abstain from nicotine/tobacco 6-8hrs prior to lab session * Not looking to quit Exclusion Criteria: * Untreated chronic medical conditions * Non-stable Rx medication * Illicit drug use * Pregnant, trying to become pregnant, breastfeeding * Not fully vaccinated for Coronavirus (e.g. COVID-19)

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Conditions

The condition(s) this trial relates to.

Cigarette Smoking nicotine dependence Vaping

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cigarette smoking E-cig use Nicotine addiction Sex differences

Contacts and locations

Locations

  • Connecticut Mental Health Center

    New Haven, Connecticut, 06519, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.