CIGARETTE SMOKING

This study looks at whether tobacco-free nicotine pouches (like Zyn) can help people who smoke cigarettes switch to a less harmful option. Fifty adult smokers will use the pouches for 4 weeks and report their smoking habits. The goal is to see if pouches reduce or replace cigaret…

This study tests if e-cigarettes can help people with opioid use disorder cut down on smoking regular cigarettes. Researchers will compare e-cigarettes to standard nicotine patches and gum, along with counseling. The goal is to see which approach works better for reducing smoking…

This study tests whether giving people with serious mental illness either e-cigarettes or nicotine patches, along with counseling and text messages, helps them cut down on smoking. 60 adult smokers who want to reduce but not necessarily quit will be followed for 12 weeks. The goa…

This study enrolls 544 smokers who want to quit but have had trouble with standard medications. Participants receive free nicotine patches, lozenges, varenicline, or e-cigarettes for 12 weeks, with treatment adjusted based on individual response. All visits are remote, and the st…

This study tests whether giving smokers who aren't interested in quitting a choice of less harmful nicotine products (like e-cigarettes or nicotine pouches) can help them reduce or stop smoking. About 472 adult smokers will be randomly assigned to try either a harm-reduction prod…

This study tests whether a once-weekly injection of semaglutide can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will receive either semaglutide or a placebo, and researchers will track changes in body weight, body fa…

This study tests whether a non-invasive brain stimulation technique called TMS can help people stop smoking. Researchers will use MRI scans to guide the stimulation to specific brain areas involved in cravings and self-control. About 64 adults who smoke at least 10 cigarettes a d…

This study looks at how a beta-blocker (propranolol) and nicotine patches, alone or together, affect smokers' brain activity and cravings when they see smoking-related cues. About 80 daily smokers will have MRI scans and rate their urges. Participants do not try to quit or take t…

This study aims to understand whether relighting a cigarette (instead of smoking it all at once) increases the amount of harmful chemicals smokers inhale. Researchers will observe 30 smokers who regularly relight, measuring their smoking habits and collecting cigarette butts. No …

This study looks at how making cigarettes very low in nicotine and changing prices of e-cigarettes and illegal cigarettes might affect what smokers buy. About 70 adult smokers will use a virtual store to see how they spend their money. The goal is to understand if these rules cou…

This study looks at how THC (the active part of cannabis) changes people's desire to smoke cigarettes and how their bodies react. Researchers will give different doses of THC or a placebo to 100 adults who smoke both tobacco and cannabis. They will measure cigarette cravings, hea…

This study looks at what happens to markers of inflammation in the blood when menthol cigarette smokers switch to non-menthol cigarettes. Inflammation is linked to heart disease risk. Researchers will measure changes in blood proteins and vital signs in 68 adult menthol smokers o…

This study compares e-cigarettes and oral nicotine pouches to see which one helps smokers reduce or stop smoking cigarettes. Two hundred adult smokers who have tried to quit before will be randomly assigned to use either e-cigarettes or nicotine pouches for six weeks. Researchers…

This study looks at whether the flavor of e-cigarettes helps smokers switch from regular cigarettes. About 210 adult smokers who have tried to quit before will be given fruit, tobacco, or menthol flavored e-cigarettes for six weeks. Researchers will track how many cigarettes they…

This study is testing a mobile health app designed to help young adults (ages 18-26) quit using e-cigarettes and other nicotine products. About 46 participants who vape regularly and want to quit will use the app and be tracked for 7-day quit success, confirmed by a saliva test. …

This study looks at how different cigarette taxes and nicotine levels change what smokers buy. About 316 daily smokers will shop in a virtual store with various tax plans. The goal is to see if taxes can encourage people to choose less harmful tobacco products.