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Sleep aid melatonin may cut painkiller needs after wisdom tooth removal

NCT ID NCT04791943

Symptom relief Sponsor: Montefiore Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether taking melatonin for three nights before wisdom tooth surgery could lower pain and the need for pain medication afterward. Sixty adults aged 18-35 took either melatonin or a placebo before their surgery. Researchers measured how many pain pills they used and checked inflammatory markers in their blood.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

60 people

The number who actually took part.

Started

Nov 2021

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction under IV sedation * Ages 18-35 * American Society of Anesthesiologists (ASA) Class I or II * English or Spanish speaking patients * Capacity to sign informed consent Exclusion Criteria: * Allergies to melatonin, opioids, or other Over-the-counter (OTC) pain medications * Anyone currently taking melatonin for any reason * Cases under local anesthesia * ASA class III or higher * Sleep disorder (insomnia/narcolepsy) * Current or past history of substance abuse * Chronic pain * Language/communication barrier * Psychiatric disease/ Mental impairment * Current or past use of psychotropic drugs * Pregnancy * Renal or hepatic impairment * BMI \>35

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Conditions

The condition(s) this trial relates to.

opiate dependence Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Narcotic use Pain, postoperative

Contacts and locations

Locations

  • Montefiore Medical Center Department of Dentistry

    The Bronx, New York, 10467, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.