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Can a smartphone app help tame chronic pain and opioid cravings?

NCT ID NCT05152134

Symptom relief Sponsor: Stanford University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a digital program called 'Empowered Relief: On-Demand' to see if it could help people with chronic pain who misuse prescription opioids. 234 adults with chronic pain and opioid misuse were randomly assigned to either the digital pain relief program or a health education program. Researchers measured pain intensity, opioid craving, and misuse over three months to see if the digital program improved outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Empowered Relief On-Demand (digital behavioral intervention)
What this could lead to
If it works, this could offer a convenient, online way to help people with chronic pain reduce their pain and cut back on opioid misuse.
What could go wrong
This is a completed Phase 3 trial, but it's relatively small (234 participants) and relies on self-reported outcomes. The digital intervention may not work for everyone, and results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

234 people

The number who actually took part.

Started

Aug 2023

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male and females 18 years of age or older * Chronic non-cancer pain (at least 6 months in duration) * Average pain intensity of at least 3 on the PROMIS SFV1.0 Pain Intensity 1a * Daily prescription opioid use (at least 10 morphine milliequivalent daily dose; MEDD) for at least 3 months * Opioid misuse (at least 6 on the Current Opioid Misuse Measure; COMM) * English fluency * Internet access Exclusion Criteria: * Gross cognitive impairment * Inability to complete study electronic surveys * Cannot currently be enrolled in a study or trial with Empowered Relief as a treatment/intervention

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome opiate dependence opioid abuse

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic pain Opioid misuse Opioid use disorder

Contacts and locations

Locations

  • Stanford University

    Palo Alto, California, 94304, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.