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Can magnetic pulses curb meth use in methadone patients?

NCT ID NCT04264741

Disease control Sponsor: Shanghai Mental Health Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study tested whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce methamphetamine use in people already receiving methadone maintenance therapy. Fifty-five adults with both opioid and methamphetamine use disorders received daily rTMS sessions for four weeks. Researchers tracked drug use through self-reports and weekly urine tests to see if the treatment helped reduce cravings and prevent relapse.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could offer a non-drug way to help people on methadone stop using methamphetamine.
What could go wrong
This is a small, early-stage trial with only 55 participants. The results may not apply to everyone, and the effect might be modest or temporary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

55 people

The number who actually took part.

Started

Feb 2020

Finished

Dec 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * aged 18-65 years * a diagnosis of OUD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and current enrollment in MMT * a diagnosis of methamphetamine (MA) use disorder according to the DSM-5 * four or more positive methamphetamine urine tests within a 4-week period * no concurrent medication treatment except for methadone * an education level of junior high school or higher * normal vision and hearing Exclusion Criteria: * severe physical or neurological conditions requiring active treatment (e.g., stroke, seizure, or traumatic brain injury) * use of cognition-enhancing medications within the past 6 months * other substance use disorders (excluding nicotine dependence) in recent five years * comorbid severe psychiatric disorders (e.g., bipolar disorder, schizophrenia, or major depressive disorder) * pregnancy or lactation among female participants * contraindications for iTBS, such as implanted devices (e.g., pacemakers, cochlear implants, neurostimulators) or intraocular metal fragments

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Conditions

The condition(s) this trial relates to.

amphetamine abuse methamphetamine dependence opiate dependence Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Methamphetamine abuse

Contacts and locations

Locations

  • Wuhan Mental Health Center

    Wuhan, China

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