Can therapy cut opioid use in chronic pain? new study explores how.
NCT ID NCT03916276
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid misuse. The goal was to understand the specific ways these treatments work, not to test a new drug or cure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help tailor psychological treatments to reduce opioid use in people with chronic pain.
- What could go wrong
- This is a small, completed study focused on understanding mechanisms, not testing a new drug or cure. Results may not apply to everyone with chronic pain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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91 people
The number who actually took part.
- Started
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Jun 2020
- Finished
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Jan 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥18 years; 2. Meet criteria for having a chronic pain problem (≥3 months, with pain experienced on ≥50% of days in past 6 months); 3. Use of opioid medication in the past week; 4. Daily average opioid analgesic medication use in the past week of ≥20 MMEs; 5. Average intensity of chronic pain ≥3 on a 10-point scale for most days of the previous 3 months; 6. Able to read, speak, and understand English; and 7. Availability of a telephone, webcam, and microphone through computer or telephone, as well as daily internet access. Exclusion Criteria: 1. Primary pain condition is headache; 2. Severe cognitive impairment; 3. Current alcohol or substance dependence; 4. Active malignancy (e.g., cancer not in remission), terminal illnesses, or serious medical conditions that may interfere with either study participation or with receiving potential treatment benefits (e.g., severe lupus); 5. Inability to walk (defined as unable to walk at least 50 yards), which would limit the ability of participants to benefit from the activation skills intervention; 6. Significant pain from a recent surgery or injury; 7. Pain condition for which surgery has been recommended and is planned; 8. Any planned surgery, procedure, hospitalization, treatment, or event that may conflict with or otherwise influence participation in the study; 9. Currently receiving or had received other psychosocial treatments for any pain condition; 10. Current or past participation in a research study with treatment components that may overlap, conflict, or affect those in the current study; 11. Current or history of diagnosis of primary psychotic or major thought disorder within the past 5 years; 12. Psychiatric hospitalization within the past 6 months; 13. Psychiatric or behavioral conditions in which symptoms were unstable or severe within the past 6 months; 14. Any psychiatric or behavioral issues as noted in the medical record or disclosed/observed during self-report screening that would indicate participant may be inappropriate in a group setting; and 15. Presenting symptoms at the time of screening that would interfere with participation, specifically active suicidal or homicidal ideation with intent to harm oneself or others or active delusional or psychotic thinking.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Washington, Ninth and Jefferson Building
Seattle, Washington, 98104, United States
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