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Can therapy cut opioid use in chronic pain? new study explores how.

NCT ID NCT03916276

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how three psychological treatments—cognitive therapy, mindfulness meditation, and behavioral activation—might help adults with chronic pain reduce their use of opioid medications. Researchers enrolled 91 people with chronic pain who were at risk of opioid misuse. The goal was to understand the specific ways these treatments work, not to test a new drug or cure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help tailor psychological treatments to reduce opioid use in people with chronic pain.
What could go wrong
This is a small, completed study focused on understanding mechanisms, not testing a new drug or cure. Results may not apply to everyone with chronic pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

91 people

The number who actually took part.

Started

Jun 2020

Finished

Jan 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥18 years; 2. Meet criteria for having a chronic pain problem (≥3 months, with pain experienced on ≥50% of days in past 6 months); 3. Use of opioid medication in the past week; 4. Daily average opioid analgesic medication use in the past week of ≥20 MMEs; 5. Average intensity of chronic pain ≥3 on a 10-point scale for most days of the previous 3 months; 6. Able to read, speak, and understand English; and 7. Availability of a telephone, webcam, and microphone through computer or telephone, as well as daily internet access. Exclusion Criteria: 1. Primary pain condition is headache; 2. Severe cognitive impairment; 3. Current alcohol or substance dependence; 4. Active malignancy (e.g., cancer not in remission), terminal illnesses, or serious medical conditions that may interfere with either study participation or with receiving potential treatment benefits (e.g., severe lupus); 5. Inability to walk (defined as unable to walk at least 50 yards), which would limit the ability of participants to benefit from the activation skills intervention; 6. Significant pain from a recent surgery or injury; 7. Pain condition for which surgery has been recommended and is planned; 8. Any planned surgery, procedure, hospitalization, treatment, or event that may conflict with or otherwise influence participation in the study; 9. Currently receiving or had received other psychosocial treatments for any pain condition; 10. Current or past participation in a research study with treatment components that may overlap, conflict, or affect those in the current study; 11. Current or history of diagnosis of primary psychotic or major thought disorder within the past 5 years; 12. Psychiatric hospitalization within the past 6 months; 13. Psychiatric or behavioral conditions in which symptoms were unstable or severe within the past 6 months; 14. Any psychiatric or behavioral issues as noted in the medical record or disclosed/observed during self-report screening that would indicate participant may be inappropriate in a group setting; and 15. Presenting symptoms at the time of screening that would interfere with participation, specifically active suicidal or homicidal ideation with intent to harm oneself or others or active delusional or psychotic thinking.

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Musculoskeletal Pain opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • University of Washington, Ninth and Jefferson Building

    Seattle, Washington, 98104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.