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Sweet smokes? study tests if sugar boosts cigarette appeal

NCT ID NCT05308316

Knowledge-focused Sponsor: Masonic Cancer Center, University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how the amount of sugar in cigarette tobacco affects how much people enjoy smoking and how addictive the cigarettes seem. Thirty adult smokers tested cigarettes with different sugar levels and answered questionnaires about their experience. The goal was to see if lower-sugar cigarettes might be less appealing and less addictive.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cigarettes with added sucrose
What this could lead to
If it works, this could point toward ways to reduce the addictiveness of cigarettes by lowering their sugar content.
What could go wrong
This is a small, early-stage study with only 30 participants, so results may not apply to all smokers. It does not test a treatment or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Feb 2022

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female age 21 years or older * Smoking cigarettes that have been evaluated to have medium levels of sugar content * No quit attempts in the past month nor intentions to quit smoking in the next month * Participants are in good physical health (no unstable medical conditions) as determined by the licensed medical professional * Participants are in stable, good mental health (e.g. not currently, within the past 6 months, experiencing unstable or untreated psychiatric diagnosis) as determined by the licensed medical professional * Stable vitals sign measurements (systolic BP ≤ 160 and \>90 mmHg, diastolic BP ≤ 100 and \>50 mmHg and heart rate ≤105 and \> 45 bpm) as determined by the licensed medical professional * Participants must be able to read for comprehension or completion of study documents (confirmed during informed consent process) * Participants have provided written informed consent to participate in the study. Exclusion Criteria: * Significant immune system disorders, respiratory diseases, kidney or liver diseases or any other medical disorders that may affect biomarker data as determined by the licensed medical professional * Women who are pregnant or nursing or planning to become pregnant.

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Conditions

The condition(s) this trial relates to.

nicotine dependence Tobacco Use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tobacco use

Contacts and locations

Locations

  • Masonic Cancer Center at University of Minnesota

    Minneapolis, Minnesota, 55455, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.