Masonic Cancer Center, University Of Minnesota

This study tests whether adding a special gut bacteria treatment (RMT) to standard immunotherapy and chemotherapy can help control advanced lung cancer better than standard treatment alone. About 82 adults with untreated, advanced non-small cell lung cancer will receive either RM…

This early-phase study tests a new drug called GTB-5550 in people with advanced solid tumors that no longer respond to standard treatments. The drug is designed to connect natural killer cells to cancer cells, helping the immune system attack the tumor. About 175 adults aged 18 a…

This early-stage trial tests whether injecting specially grown muscle cells into the feet of adults with Duchenne muscular dystrophy is safe. Only 8 non-ambulatory participants will receive the cells, made from stem cells in a lab. The main goal is to find a safe dose, not yet to…

This study tests a new immune cell treatment called AdaptNK for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses specially grown natural killer cells from a donor to attack the leukemia, followed by a stem cell t…

This early-phase trial tests a specially modified virus that is injected directly into pancreatic tumors during an endoscopic procedure. The goal is to find the safest dose and see if the virus can help control the disease. The study enrolls 18 adults with pancreatic adenocarcino…

This study tests a stem cell transplant using a person's own cells to treat Hodgkin and non-Hodgkin lymphoma. It includes people with HIV. The goal is to see if a radiation-free treatment plan helps patients live longer without their cancer returning. About 150 adults will take p…

This study tests a new way to prepare donor stem cells for transplant in people with blood cancers like leukemia. By removing certain immune cells from the donated cells, researchers hope to lower the risk of graft-versus-host disease, a serious side effect. The study involves 70…

This study tests a special stem cell transplant that removes certain immune cells to lower the need for strong anti-rejection drugs. It is for people with inherited bone marrow failure disorders like Fanconi anemia. The goal is to help the immune system recover faster and reduce …

This study tests a two-step treatment for children and young adults with high-risk neuroblastoma. After initial chemotherapy, patients receive two rounds of very strong chemo, each followed by an infusion of their own stem cells to help the body recover. The goal is to keep the c…

This study tests a treatment for people whose stem cell transplant fails to work (graft failure). The treatment uses chemotherapy and low-dose radiation to help donor cells grow and start making blood cells again. The goal is to see if this approach can restore donor cell functio…

This study tests a stem cell transplant from a healthy donor for people with serious blood disorders like sickle cell disease or thalassemia. The goal is to replace the faulty blood cells with healthy ones, reducing the need for lifelong transfusions. Participants will receive a …

This early-phase trial tests a new drug called FT536 for adults with a severe type of brain cancer (WHO Grade 4 astrocytoma) that has come back after standard treatment. The drug is injected directly into the tumor during surgery. The main goal is to see if it is safe and tolerab…

This study tests a stem cell transplant using a milder chemotherapy combination (treosulfan and fludarabine) followed by donor stem cells and drugs to prevent graft-versus-host disease. It includes 132 people aged 2-75 with blood cancers like AML or MDS. The goal is to see if thi…

This early-phase study tests a new approach called peptide alarm therapy (PAT) given as an injection directly into tumors, along with a standard immunotherapy drug, for people with advanced solid tumors that have stopped responding to at least one prior treatment. The goal is to …

This study tests whether offering free legal services to people caring for a loved one with advanced colorectal cancer can reduce their stress and improve their finances. About 20 patient-caregiver pairs will receive personalized legal help from a nonprofit. The goal is to see if…

This study tests if a nerve block using long-lasting numbing medicine works as well as an epidural for pain after pancreatic surgery. About 78 adults having this surgery will be randomly assigned to one of the two methods. The goal is to see if the nerve block provides similar pa…

This study looks at using unlicensed umbilical cord blood units for stem cell transplants in people with blood cancers or immune system diseases. Researchers want to see if these units are safe and how many stem cells they contain. Up to 250 participants will be monitored for inf…

This study looks at how much harmful chemicals from fire smoke get into firefighters' bodies. Researchers will collect urine and cheek cell samples from 60 firefighters before and after they fight a real structural fire. The goal is to measure changes in toxin levels to better un…

This study tests a tool kit called SALSA that tracks stress, mood, and speech to spot thinking problems early in people receiving CAR-T therapy for cancer. About 38 adults will use the tool during their hospital stay. The goal is to see if it's practical and better than current m…

This study looks at how the heart and lungs work during exercise in young people (ages 8-25) who have survived a heart transplant, leukemia, or were born with chronic lung disease. Researchers will use special tests to measure oxygen use and heart function while participants exer…

This study aims to understand whether relighting a cigarette (instead of smoking it all at once) increases the amount of harmful chemicals smokers inhale. Researchers will observe 30 smokers who regularly relight, measuring their smoking habits and collecting cigarette butts. No …

This study creates a national registry for people with adrenoleukodystrophy (ALD) and their families. Researchers will collect medical records and survey data every six months to understand how the disease progresses and to find biological markers. Up to 1,000 participants of any…