Masonic Cancer Center, University Of Minnesota

This study tests whether giving a drug called E7777 before standard CAR-T cell therapy can help people with relapsed or hard-to-treat large B-cell lymphoma. About 30 participants will receive E7777 followed by chemotherapy and an approved CAR-T product. The goal is to find the sa…

This study tests a new way to grow stem cells from umbilical cord blood to help people with high-risk blood cancers like leukemia and lymphoma recover faster after a bone marrow transplant. About 22 patients will receive the expanded stem cells along with standard chemotherapy an…

This study tests a donor stem cell transplant to treat severe immune system problems in 57 people. The goal is to help the body make healthy blood cells and fight infections. Patients must have a specific immune disorder and meet health criteria to join.

This early-phase study tests whether giving two drugs—dexamethasone (into the spine) and simvastatin (by mouth)—can safely prevent serious brain side effects in adults receiving CAR-T cell therapy for certain types of lymphoma. About 37 people with hard-to-treat B-cell lymphomas …

This study tests a stem cell transplant method for people with inherited metabolic disorders and severe osteopetrosis. The goal is to see if a donor's stem cells can successfully take over the patient's bone marrow while keeping side effects low. Participants receive chemotherapy…

This early-phase trial tests a new treatment called FT536 for people with ovarian, fallopian tube, or primary peritoneal cancer that has come back. The treatment is given directly into the belly three times in one week, after a short course of chemotherapy to prepare the body. On…

This study tests FDA-approved CAR-T cell therapy in 150 people with certain blood cancers (acute lymphoblastic leukemia or large B-cell lymphoma) that have not responded to standard treatments. Participants receive their own immune cells that have been reprogrammed to attack canc…

This early-phase study is testing whether a combination of high-phenolic extra virgin olive oil and curcumin is safe and can help reduce skin tumors in adults with neurofibromatosis type 1 (NF1). Twenty-three participants take the supplements twice daily for up to 12 months. The …

This study looks at whether kava, a plant-based supplement, can safely help reduce anxiety and stress in people who have finished cancer treatment. About 43 cancer survivors with mild anxiety will take either kava or a placebo for 14 days, then switch after a break. The goal is t…

This study looks at how much time people with advanced breast or ovarian cancer spend on cancer-related tasks like appointments, travel, medications, and paperwork. About 78 participants will use a smartphone app for 28 days to track their activities and complete daily surveys. T…

This study looks at how nornicotine, a chemical found in smokeless tobacco, turns into a cancer-causing substance called NNN inside the body. Researchers will measure this process in 55 adult smokeless tobacco users to understand how different levels of nornicotine affect cancer …

This study looks at how children with a rare genetic disease called MPS IH process a drug called laronidase before and after a stem cell transplant. Researchers will collect blood samples from 13 children up to 3 years old to see how body size and the new cells from the transplan…

This study looks at what happens to chemicals in the body when smokers switch to a special research e-cigarette. About 47 adult smokers who smoke at least 5 cigarettes daily will use the e-cigarette for a period. Researchers will measure nicotine and other harmful substances in u…