Can a simple drug combo stop CAR-T brain toxicity?
NCT ID NCT04514029
First seen Jan 09, 2026 · Last updated May 25, 2026 · Updated 19 times
Summary
This early-phase study tests whether giving two drugs—dexamethasone (into the spine) and simvastatin (by mouth)—can safely prevent serious brain side effects in adults receiving CAR-T cell therapy for certain types of lymphoma. About 37 people with hard-to-treat B-cell lymphomas will take part. The main goal is to see if the treatment plan is feasible and safe, not yet to prove it works.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Masonic Cancer Center, University of Minnesota
Minneapolis, Minnesota, 55455, United States
Conditions
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