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Zapping the brain to fight opioid cravings: small study shows promise

NCT ID NCT05049460

Symptom relief Sponsor: Gopalkumar Rakesh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a type of brain stimulation called theta burst stimulation (TBS) could reduce cravings and attention to drug-related cues in 23 people with both opioid and tobacco use disorders. Participants received four sessions of real or fake TBS in one day while their cravings and eye movements were measured. The goal was to see if TBS could help them focus less on smoking and opioid triggers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Theta burst stimulation (TBS) - a type of brain stimulation using magnetic pulses
What this could lead to
If it works, this could point toward a non-drug way to help people with opioid and tobacco addiction manage cravings and reduce relapse risk.
What could go wrong
This is a very small, early study with only 23 participants. The results may not apply to everyone, and the effects on real-world drug use are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23 people

The number who actually took part.

Started

Sep 2021

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients enrolled in the SMART Clinic at University of Kentucky * 18-60 years of age * Preferably right hand dominant * Currently self-report smoking 10 of more cigarettes per day or a score of \> 5 on the Fagerstrom Test for Nicotine * Willing and able to abstain from all drug use * Exhaled breath on day of study CO \< 10 ppm * Stabilized on maintenance buprenorphine if having comorbid opioid use disorder * Able to read and speak English * Able to provide informed consent to participate. Exclusion Criteria: * Pregnant, nursing, or becoming pregnant during the study. * History of traumatic brain injury or seizures which are contraindications for transcranial magnetic stimulation (TMS). * Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 5 minutes which are all contraindications for TMS. * Presence of intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus nerve stimulation device which are all contraindications for magnetic resonance imaging. * Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm, major neurocognitive disorder, Huntington chorea; multiple sclerosis which are all contraindications for TMS.

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Conditions

The condition(s) this trial relates to.

nicotine dependence opiate dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opioid-use disorder Tobacco use disorder

Contacts and locations

Locations

  • 245 Fountain Court

    Lexington, Kentucky, 40513, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.