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Brain scans reveal recovery during cannabis abstinence

NCT ID NCT03104257

Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how cannabis use affects brain receptors and electrical activity, and how these change when people stop using. Researchers used brain scans and EEGs in 162 people, including cannabis users and healthy controls. The goal was to understand the brain's recovery process during abstinence.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
[11-C]OMAR (a radioactive tracer used for PET scans)
What this could lead to
If successful, this study could help us understand how the brain recovers after stopping cannabis use, potentially guiding future treatments for cannabis dependence.
What could go wrong
This is an observational study, not a treatment trial. It only measures brain changes and does not test any therapy, so it won't directly lead to a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

162 people

The number who actually took part.

Start date

Dec 2016

Finished

Apr 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Research subjects can be both cannabis-using or non-cannabis using males and females between the ages of 18-65.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Cannabis Dependent Subjects * Current cannabis consumption * Willing to abstain from cannabis use for four weeks Inclusion Criteria for Healthy Controls * No current cannabis consumption Exclusion Criteria: * MRI metal exclusions and claustrophobia * Education completed is less than 12 years

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Conditions

The condition(s) this trial relates to.

cannabis dependence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cannabis dependence Healthy

Contacts and locations

Locations

  • Conneticut Mental Health Center

    New Haven, Connecticut, 06519, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.