Overnutrition

Researchers are testing an experimental oral drug called MDR-001 in healthy adults and in people who are overweight or obese. The trial gives single and increasing repeated doses to see how the body processes the drug and whether it causes side effects. They also measure changes …

Researchers are testing whether a 24-month weight-loss program delivered by trained health coaches through an electronic medical record patient portal can help Black adults with obesity and type 2 diabetes or prediabetes. The study enrolls 352 people aged 40 to 70 in Louisiana pr…

Researchers compare two weight-loss strategies in 66 obese women: a 16:8 time-restricted eating plan (fasting 16 hours, eating within 8 hours) plus home exercise, versus a standard calorie-restricted diet plus home exercise. Over 12 weeks, they measure changes in body composition…

This study is testing whether adding an experimental anti-inflammatory drug called NT-0796 to the weight-loss medication semaglutide can help people with obesity lose more weight and reduce inflammation. About 82 adults with a BMI of 30 to 45 will take either the combination or a…

This study tests whether survodutide, a weekly injection for weight loss, is safe for the heart in people who are overweight or obese and have heart or kidney disease. About 5,500 adults will receive either survodutide or a placebo for up to 2 years, along with diet and exercise …

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This phase 3 trial tests whether VCT220, a daily pill that targets GLP-1 receptors, can help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or placebo for 12 months. The main goals are to see how much weight they lose and ho…

This completed study tested whether eplerenone, a drug that blocks a hormone called aldosterone, improves blood flow and reduces scarring in the heart more than another drug, chlorthalidone, in 79 people with obesity and high blood pressure. Participants took one of the two drugs…

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

Researchers compare three weekly GLP-1 receptor agonists, dulaglutide, semaglutide, and tirzepatide, in 159 obese adults, 84 with diabetes and 75 without. Participants receive one of the drugs for 24 weeks. The trial measures changes in body weight, BMI, blood sugar, cholesterol,…

This phase 3 trial tests whether a once-daily pill called orforglipron can improve sleep apnea in 600 adults with moderate-to-severe sleep apnea who are also obese or overweight. Participants are split into two groups: those who cannot or will not use a CPAP machine, and those wh…

Researchers examined whether dietary advice based on continuous glucose monitoring (CGM) helped overweight college students improve body weight and composition. The study analyzed archived records from 59 students who wore CGM sensors for four weeks; half received personalized di…

This completed phase 3 trial tested whether a lifestyle program (diet and exercise) plus the drug metformin could reverse frailty and sarcopenic obesity in 114 older veterans aged 65-85. Participants followed a weight-loss diet and exercised three times a week, while taking metfo…

This study tests whether a mango and chia-based drink can improve the gut bacteria of 100 obese children aged 8 to 16 in Paraguay. The children will drink the beverage for 6 weeks, and researchers will analyze their stool samples before and after to see if the drink changes their…

This early study is testing a new magnetic device that creates a shortcut in the digestive system to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI between 30 and 35 will have the device placed using a scope, wit…

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

Researchers compare two weight-loss operations in adults with Class IV obesity, defined as a body mass index of 50 or higher. One group receives standard sleeve gastrectomy, where surgeons remove most of the stomach. The other receives the same operation plus a polypropylene band…

This study tests a new magnetic system (MagDI) that creates a connection between two parts of the small intestine to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the device is safe, works as intended,…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This early-stage trial tests the safety of a new oral drug, IBI3032, in 104 people. Part A gives a single dose to healthy volunteers, while Part B gives multiple doses over 4 weeks to people with overweight or obesity. The goal is to check for side effects and how the drug moves …

This study tests a program called TOTAL that uses an educational video and three telemedicine calls to encourage veterans with obesity to start weight loss treatments like the MOVE! program, medications, or surgery. About 440 veterans will take part. The goal is to see if this si…

This study tests a program called ROC+ to help people who are very responsive to food cues lose weight. It compares ROC+ to standard behavioral weight loss programs in 300 adults with overweight or obesity. The goal is to see if reducing reactions to food cues leads to lasting we…

This Phase 2 trial tests a once-weekly injection called petrelintide in 221 people with overweight or obesity and type 2 diabetes. Participants receive either petrelintide or a placebo for several weeks. The main goal is to see how much weight they lose and whether blood sugar im…

This study examines weight loss in adults who took semaglutide (a prescription weight management drug) as part of their routine care. Researchers will analyze medical records from about 35,000 people with overweight or obesity to see how much weight they lost and whether they ach…

This early-stage study will compare two different versions of the drug cagrilintide in 50 adults with overweight or obesity. Participants will receive injections of either version for several weeks, and researchers will measure how the drug builds up in the body. The goal is to s…

This phase 3 study tested an experimental once-daily pill called orforglipron (LY3502970) against a placebo in 1613 adults who are overweight or have obesity and type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants…

This trial tests whether an artificial intelligence system can improve weight loss coaching by personalizing it for each participant. Adults with overweight or obesity receive either standard weekly group coaching or an AI-optimized version that adjusts the type and intensity of …

This study tests whether weighing yourself every day can help teens with obesity manage their weight. About 99 teens aged 12 to 18 will be split into three groups: usual care, usual care plus a simple scale, or usual care plus a smart scale that sends data to their doctor. The st…

Researchers at the University of Aberdeen are testing whether eating all meals within a 10-hour window, while fasting for the other 14 hours, can improve appetite control in adults with overweight or obesity. The study also compares different meal frequencies within that window, …

This phase 2 trial tests an experimental drug called MWN105, given as a weekly injection, in adults who are overweight or have obesity but do not have diabetes. About 120 participants will receive different doses of MWN105 or a placebo for 24 weeks. The main goal is to see how mu…

This early-stage trial tests an investigational drug called MWN105, given as an injection under the skin, in healthy Chinese volunteers aged 18 to 45. The study aims to check the drug's safety, how the body processes it, and whether it triggers an immune response. Researchers wil…

This trial tests an oral medication called MWN109 in Chinese adults with type 2 diabetes, overweight, or obesity. Researchers want to see if the amount of water taken with the pill and the timing of the next meal change how much drug enters the blood. The study also checks safety…

Researchers are testing whether a supplement that activates sirtuins, proteins linked to metabolism, can enhance weight loss in adults with overweight or obesity. In this 24-day trial, participants follow a weight loss diet and receive either the supplement or a placebo. The stud…

This trial tests whether taking a daily supplement of cornelian cherry fruit for six months can improve markers of heart, blood vessel, eye, and bone health in people with metabolic syndrome. Participants will receive either the cherry supplement or a placebo, and researchers wil…

This study tests whether specialized bariatric supplements (Elan Believe, Compass, Supreme) prevent vitamin and mineral deficiencies after weight-loss surgery better than standard over-the-counter multivitamins. Over 600 adults undergoing sleeve gastrectomy, gastric bypass, or on…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This study reviews medical records of 500 adults with obesity or overweight who took a combination of sibutramine and topiramate for at least three months. The goal is to see how much weight they lost and if the treatment was safe and tolerable. This is a low-cost option that may…

This study tests whether a daily multivitamin tablet can prevent vitamin and mineral deficiencies in people using GLP-1 drugs (like Ozempic or Saxenda) for weight loss. These drugs suppress appetite, which can lead to low nutrient intake. The trial will compare a multivitamin to …

This trial tests a structured diet and exercise program for overweight Chinese cancer survivors. The program, led by a dietitian and a cancer exercise specialist, teaches weight loss strategies, healthy eating, and physical activity. Researchers want to see if the program is prac…

This study tests whether eating more plant-based foods or taking polyphenol supplements (like green tea and berry extracts) can help overweight adults lose weight and improve heart health. 99 participants will follow a calorie-restricted diet for 12 weeks, with one group eating e…

This trial tests whether limiting eating to an early window (7 AM to 3 PM) or a late window (12 PM to 8 PM) helps adolescents with obesity lose weight and lower their body mass index. Participants aged 12 to 21 with obesity will follow one of these eating schedules for 24 weeks. …

This trial tests whether two different pen injectors deliver the same amount of CagriSema, a combination of cagrilintide and semaglutide, into the body. Adults with overweight or obesity receive a single injection of each version at separate visits, and researchers measure the dr…

This trial tests whether an essential amino acid supplement can lower fat stored in the liver of teenagers with non-alcoholic fatty liver disease (NAFLD). Participants aged 13 to 18 will take the supplement or a placebo for two months, and researchers will measure liver fat with …

This randomized crossover trial tests whether nutritionally improved bread and bakery products—with less saturated fat and sugar and more fiber—can positively affect body composition and metabolic health in children aged 6 to 12 with overweight or obesity. Participants will consu…

This trial tests whether a 12-week ketogenic diet—low in carbs and high in fat—can influence thyroid function and glucose-insulin metabolism in premenopausal women aged 30-50. Participants across different body weight categories will follow individualized meal plans, with blood t…

This trial investigates whether high-intensity interval training (HIIT) can improve how the body uses insulin in obese adults with glucose intolerance. Participants will be assigned to either HIIT (short bursts of intense exercise) or moderate-intensity continuous training (MICT,…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This trial tests whether a 'physical activity on prescription' (PAP) program can help children aged 6-12 with obesity become more active. Over 4 months, children choose activities they enjoy and follow a written prescription for how often and how long to do them. Researchers will…

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This Phase 3 trial is testing whether a once-daily 50 mg semaglutide tablet can help East Asian adults with overweight or obesity lose weight. Participants will take either the active tablet or a placebo for 68 weeks, alongside lifestyle counseling on diet and physical activity. …

This study tests whether a supplement made from brown algae and chromium picolinate, when added to a calorie-controlled Mediterranean diet, can reduce fat buildup in the liver. Adults with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic syndrome wil…

This trial follows women with polycystic ovary syndrome (PCOS) who take metformin, a standard diabetes medication, for six months. Researchers track changes in insulin resistance, iron levels, erythropoietin, cholesterol, and blood counts at three and six months. The goal is to s…

This study looks at whether giving tranexamic acid during weight-loss (bariatric) surgery can reduce bleeding. Researchers will compare patients who received the drug with those who did not, focusing on drops in hemoglobin levels, need for transfusions, hospital stay length, and …

This study tested a lifestyle program to help pregnant women with obesity maintain their weight and lose body fat during pregnancy. About 100 women in early pregnancy took part, receiving either the program or standard care. The goal was to see if the program could improve mother…

This study tests an experimental daily pill called aleniglipron for weight loss in 220 adults with obesity or overweight who also have a weight-related health issue. Participants receive either the drug or a placebo for 36 weeks, with the option to continue on the drug for anothe…

This trial tests whether a 12-week calorie-restricted diet, combined with the weight-management drug Contrave, can help people with type 2 diabetes and obesity achieve remission. Remission means blood sugar levels drop below the diabetes threshold without needing glucose-lowering…

This trial tests whether a 12-week program of eccentric cycling—where muscles lengthen under load, like pedaling against resistance—can reduce body fat in overweight and obese teenagers more effectively than traditional concentric cycling. The study compares both types of exercis…

This study looks at whether a follow-up surgery called Single Anastomosis Duodenal Ileal Bypass (SADI) can help people who had a sleeve gastrectomy but didn't lose enough weight. Participants are adults with severe obesity who lost less than 10% of their body weight after the fir…

This trial tests whether a single yogurt drink made from vegetable proteins rich in leucine, cysteine, and arginine can improve blood vessel function and reduce inflammation in older adults with cardiometabolic risk. Participants, aged 65 and older, will consume either the vegeta…

This trial tests whether doing a short bout of exercise right before or right after a meal changes how much adolescents with obesity eat and how hungry they feel. Teens aged 12-16 will either rest or exercise at specific times, then eat a buffet meal where their intake is measure…

This trial asks whether the amount of daily energy turnover—how much energy is used through diet and exercise—can influence appetite and food reward in adolescents with obesity. Eighteen teens aged 12-16 will each complete three sessions with low, moderate, or high energy turnove…

This trial tests whether taking polyphenol supplements with a meal can reduce how much iron the body absorbs in people with iron overload disorders like genetic hemochromatosis and dysmetabolic iron overload syndrome. Participants eat a standardized iron-rich meal with either pol…

This trial tests whether a smartphone app called Kiplin, which uses games, telecoaching, and social support, can increase daily physical activity in people with obesity or type 2 diabetes. It compares the app to a standard three-month face-to-face exercise program. The main goal …

This trial tests whether time-restricted eating (TRE) — limiting all food intake to an 8-10 hour daily window — can improve blood sugar control and metabolic health in people with metabolic syndrome or prediabetes. Participants are randomly assigned to either standard nutritional…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This trial tests whether standing on a vibrating platform for short sessions, twice a week, can boost heat production (thermogenesis), improve heart health markers, and reduce inflammation in adults with obesity. Participants will be assigned to one of two types of vibrating plat…

This trial tests whether intermittent energy restriction (alternating normal and reduced-calorie days) works better than continuous daily calorie cutting for weight loss in women with obesity. Researchers will measure changes in body fat, muscle mass, and metabolic adaptation — t…

This study tests an experimental once-daily oral drug called orforglipron in Japanese adults with obesity and related health problems like high blood pressure or type 2 diabetes. Participants receive either orforglipron or a placebo for 72 weeks. The main goals are to measure wei…

This study looks at whether replacing sugary drinks (like soda and sports drinks) with calorie-free alternatives (like diet drinks or water) can help adults with overweight or obesity lose weight. About 460 people who drink at least one sugary drink per day will be assigned to on…

This study tests a new magnetic device that creates connections between parts of the gut during weight-loss surgery. The goal is to see if it is safe and works as intended in 28 adults with severe obesity. If successful, it may offer a simpler way to perform these surgeries.

This trial compares robotic and laparoscopic sleeve gastrectomy in people with obesity to see which approach is faster and safer. Participants are randomly assigned to one of the two surgical methods. The study measures operative time, bleeding, and complications like leaks or co…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This study tests whether the weight-loss drug tirzepatide can increase the activity of brown and beige fat—special fat cells that burn energy instead of storing it. The trial includes women with obesity who will receive either tirzepatide or a placebo for 24 weeks. Researchers wi…

This study tests whether combining lifestyle counseling with weight-loss medication helps teens aged 12–17 with severe obesity lose weight. About 120 participants will receive counseling and medication for a year. The goal is to find a practical, effective treatment that is easie…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study tests whether adding a canine health-literacy module to an existing family lifestyle program helps overweight teens and their parents become more active. The program includes lessons on dog care, behavior, and exercise, along with activity trackers and surveys. Partici…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study is testing a new device called SEGER IDEA™ that helps surgeons close openings in the bowel during keyhole surgery. It is the first time this device is being used in humans. Ten adults having certain types of bowel surgery will take part. The main goal is to see if the …

This study tested a 12-week program for Hispanic mothers with overweight or obesity and their 3-5 year old children. The program included weekly classes on nutrition, exercise, and coping skills, plus exercise sessions. Researchers measured changes in weight, body fat, and health…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study tests whether a dietary supplement called Satisens®, made from lemon verbena, hibiscus, saffron, and carob extract, can help reduce emotional eating and cravings for sweets in healthy adults who are overweight or obese. Participants take two capsules daily for a set pe…

This trial investigates whether adding hypnosis sessions to standard dietary monitoring can help people lose weight after bariatric surgery has not worked. About 25% of patients do not achieve lasting weight loss from surgery alone. The study enrolls 60 adults aged 18-65 with obe…

This study tested whether eating probiotic-enriched pasta daily for 4 weeks could improve metabolic health and reduce inflammation in overweight and obese adults. Forty healthy men and women with a BMI between 25 and 35 ate either probiotic pasta or regular pasta. Researchers mea…

This study tests a new, non-surgical weight loss method called endoscopic Gastric Mucosal Ablation (GMA). It uses a thin tube and heat to treat the stomach lining, aiming to help people with obesity lose weight. The study involves 15 participants and will follow them for up to 12…

This small pilot study tested the safety of a swallowable intra-gastric balloon (IGBalloon) for weight loss in 5 people with obesity. Participants swallowed up to 5 balloons over 8 weeks, with regular check-ups including blood tests and endoscopies. The study also looked at weigh…

This study looked at whether a supervised exercise program, started 3 months after bariatric surgery, helps improve body composition, muscle strength, and insulin resistance. 61 adults with severe obesity took part. Participants were randomly assigned to either an exercise group …

This study looked at whether giving protein supplements after sleeve gastrectomy surgery helps patients keep their muscle mass while losing weight. 90 obese adults who had the surgery took part. Researchers measured changes in lean body mass and other health markers over 5 weeks.

This study tested a new once-weekly injection called MET097 in 133 adults with obesity or overweight and type 2 diabetes. The goal was to see if it helps with weight loss and blood sugar control compared to a placebo. Participants received either the drug or a placebo for 28 week…

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This study tested two mobile apps for parents of children aged 2 to 5. One app focused on nutrition, physical activity, and sleep; the other on reading. Researchers wanted to see if the apps could help parents encourage healthier habits and lower obesity risk. Over 200 parents in…

This Phase 2 study tested a once-daily pill called RGT001-075 in 267 adults who are obese or overweight with weight-related health problems like high blood pressure or sleep apnea. The goal was to see if the drug helps with weight loss and is safe. Participants took either the dr…

This study tested a new daily pill called DA-302168S in 250 overweight or obese adults. The pill works like a natural hormone to control appetite. Researchers measured weight loss and side effects over 16 weeks. The goal is to see if this pill is a safe and effective option for w…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This study tested a mental strategy called WOOP (Wish, Outcome, Obstacle, Plan) to help veterans with obesity lose weight. Over 400 veterans were split into two groups: one got the VA's standard weight program (MOVE!) plus WOOP, the other got MOVE! alone. The goal was to see if a…

This study tested a new surgical technique called FundoRing, where the surgeon wraps the unused part of the stomach around the new stomach pouch during gastric bypass. The goal is to improve weight loss and reduce bile reflux compared to the standard bypass. One thousand adults w…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This pilot study tested a 4-month program that combines weight loss strategies with stress management techniques for Black breast cancer survivors who have obesity and high stress. The program is based on the Diabetes Prevention Program and includes 16 sessions. Researchers measu…

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This study tested whether eating a fermented pea-and-legume product for three weeks could improve gut health and reduce inflammation in people with metabolic syndrome. 56 adults with a large waist and at least one other risk factor (like high blood sugar or cholesterol) took part…

This study looked at whether eating only during a 10-hour window each day and doing high-intensity interval training three times a week can improve health in people with metabolic syndrome. Two hundred adults took part for 16 weeks. Researchers measured changes in metabolic syndr…

This study explored whether using a mobile app and a Fitbit Inspire 3 tracker can help adults with metabolic syndrome become more physically active. One hundred participants were split into two groups: one used the digital tools plus usual care, the other received usual care alon…

This study looked at 60 men with metabolic syndrome who also had erectile dysfunction and early signs of heart stiffness. Researchers compared three treatments: tadalafil (a common ED drug), an SGLT2 inhibitor (a diabetes drug), and a combination of both, given for three months. …

This study looked at 150 teens aged 12-17 with severe obesity to find the best time to add a weight-loss pill (phentermine) if lifestyle changes alone weren't enough. Participants first tried lifestyle therapy for 12 or 24 weeks, then those who didn't lose enough weight started t…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study tested two versions of a low-calorie Mediterranean diet, each with different carb and fat levels, combined with moderate aerobic exercise in 36 adults with obesity and fatty liver disease (NAFLD). The goal was to see if one diet plan worked better than the other at red…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could…

This study tested whether a probiotic supplement (Pediococcus acidilactici) could reduce metabolic problems like high cholesterol and blood sugar caused by antipsychotic drugs. 36 adults with first-episode psychosis or schizophrenia took the probiotic or a placebo alongside their…

This study tested a program called HealthyWE in 60 older adults in Camden, New Jersey, to help them manage their weight and reduce pain. The program included training on healthy eating, staying active, and mental wellness. Researchers measured changes in body mass index and pain …

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This study tested whether a 16-week lifestyle program delivered through WeChat could help children with autism (ages 8-12) manage their weight. 276 families were split into three groups: usual care, the WeChat program alone, or the program plus weekly group coaching. The main goa…

This study tested whether a daily cocoa flavonol supplement could improve body composition, metabolism, and inflammation in 104 obese teenagers aged 10 to 16. Participants took either the supplement or a placebo for 12 weeks, alongside standard diet and exercise advice. The goal …

This study tested a device that uses self-forming magnets to create new connections in the gut. It was done in 28 adults with severe obesity who had already had weight-loss surgery but did not lose enough weight. The goal was to see if the device is safe and works as intended. Th…

This study tested whether weighing yourself daily with a wireless scale can help adults with obesity manage their weight. About 400 people from primary care clinics took part. They were asked to weigh themselves each day and see their weight trend on the scale's display. The goal…

This study compared two types of gastric bypass surgery for obesity to see which one leads to fewer problems like acid reflux and stomach ulcers. Two hundred adults with a BMI between 30 and 50 took part. The goal was to find out which surgical method is safer and more effective …

This study tested a 'digi-physical' approach for families with children or teens living with obesity. Participants either received standard in-person care or a mix of digital tools (an app for tracking health and chatting with caregivers) plus fewer in-person visits. The goal was…

This completed study gave 580 Native American adults and children in Osage Nation weekly boxes of fresh fruits and vegetables along with healthy recipes and cooking classes. The goal was to see if this program could improve diet, lower blood pressure, and reduce health risks like…

This completed study looked at how two common diabetes drugs, dapagliflozin and empagliflozin, affect weight, cholesterol, and inflammation in 260 obese adults newly diagnosed with type 2 diabetes. Over six months, researchers measured changes in body weight, blood fats, and mark…

This study looked at whether eating fermented plant-based foods (like certain vegetables and grains) can improve health in people with metabolic syndrome—a condition that raises risk for heart disease and diabetes. About 89 adults with signs of metabolic syndrome ate either ferme…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This study tested whether sending specific motivational messages at just the right moment helps young adults with overweight or obesity meet their daily weight loss goals. Over 200 participants used a smartphone app with a weight loss program, and some received extra messages tar…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested whether a virtual weight control program combined with a continuous glucose monitor could help adults with type 2 diabetes lower their blood sugar levels. 152 overweight or obese adults with type 2 diabetes participated. The program used the WW (Weight Watchers)…

This study looked at 192 women with PCOS to see which treatment works best for improving insulin resistance and other symptoms. Participants were randomly assigned to take metformin, inositol, follow a calorie-restricted diet, or combine all three for 12 weeks. The goal was to fi…

This completed study looked at how intermittent fasting and the Mediterranean diet affect body composition and nutrition knowledge in 100 overweight or obese adults. Participants followed one of the two diets for a set period. The goal was to see which approach leads to better we…

This phase 2 study tested whether adding apitegromab (a drug that blocks a muscle-weakening protein) to tirzepatide (a GLP-1 weight-loss drug) helps overweight and obese adults lose fat while keeping lean muscle. 102 participants received either the combination or placebo over 24…

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with guidance on diet and exercise. The main goals were to measure the percentage of weig…

This study looked at whether losing weight through a controlled diet, along with a regular exercise program, can improve fitness in obese older adults. 180 sedentary people aged 60 and older with a BMI between 30 and 35 took part. The goal was to see if more fat loss leads to gre…

This study looked at whether eating only between certain hours (a 10-hour window each day) and choosing foods that are less calorie-dense (fewer calories per bite) can help older adults with obesity and insulin resistance. Forty participants followed this eating pattern, and rese…

This study looked at whether eating more dairy products for 6 weeks could lower inflammation and other signs of heart disease in overweight adults. Thirty-two people with low dairy intake and at least two other risk factors (like high blood pressure or blood sugar) took part. Res…

This study tested two ways to help food-insecure adults with heart risks eat more fruits and vegetables. One group got a $20 grocery credit every two weeks, the other got a box of produce delivered to their home. Researchers measured changes in diet and food security over time.

This study tested whether adding social gaming (earning points and supporting each other) to a weight loss app helps adults with overweight or obesity and at least 3 risk factors for type 2 diabetes lose more weight over 12 months. About 240 adults used a mobile app to track food…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study tested a new weekly injection called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help Chinese adults with obesity or overweight lose weight. About 300 participants received either CagriSema, semaglutide alone, or a placebo for around one year…

This pilot study tested a 6-month program combining group classes, personal coaching, and a low-carb diet to help people with early type 2 diabetes lose weight and possibly reverse their condition. It involved 35 overweight adults in low-income Memphis neighborhoods. The goal was…

This study tested whether a special fiber supplement, combined with a healthy Mediterranean diet and lifestyle changes, could improve gut bacteria and metabolic health in children with obesity. 36 children aged 8-14 took part for 8 months. The goal was to see if this approach cou…

This study tested whether a structured, intensive lifestyle program could help overweight or obese people with metabolic syndrome achieve remission. 68 participants followed a program aiming for 15% weight loss. The goal was to see if this approach could reduce the number of meta…

This study tested whether giving a higher dose of oxytocin (a drug that strengthens contractions) could lower the rate of C-sections in obese women having their first baby. Over 400 women took part, receiving either a standard or a higher dose during labour. The goal was to see i…

This study looked at whether drinking hydrogen-rich water every day for 12 weeks can improve body composition and metabolic health in adults with metabolic syndrome. 40 adults participated, and researchers measured changes in waist size, body fat, blood sugar, and cholesterol. Th…

This study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …

This study compared two types of weight-loss surgery in 256 adults with severe obesity. The goal was to see if a newer, simpler surgery (Omega Loop bypass) works as well as the standard Roux-en-Y gastric bypass, with fewer side effects. Participants were followed for two years to…

This study tested a 24-week program that combines WeightWatchers behavioral coaching with prescription GLP-1 medications like Wegovy, Mounjaro, or Zepbound. 180 adults with obesity or weight-related conditions participated. Researchers measured weight loss and related outcomes at…

This study tested whether a daily combination of commercially available food supplements could help overweight adults over 45 feel fuller and improve their cholesterol and blood sugar levels. Eighty participants were split into two groups: one took the supplement mix for 12 weeks…

This study looked at whether having a peer coach (a trained person like you) helps people with obesity lose more weight than trying on their own. 375 adults aged 21-75 with a BMI between 30 and 50 took part. The main idea was to see if coach support leads to greater weight loss t…

This study tested two weight loss programs in 223 overweight or obese adults aged 21-75. One group followed a fixed calorie reduction plan, while the other varied their calorie intake. The goal was to see which approach leads to more weight loss over time.

This study tested a 12-month healthy lifestyle program for 112 youth aged 8-18 with serious emotional disturbance who were overweight or obese. Participants worked with a health coach to improve diet and physical activity, with parents involved. The goal was to see if this approa…

This completed study tested two ways parents can help teens with obesity maintain weight loss. 418 teens (ages 12-16) and their parents took part. One group focused on teaching parents coaching skills, the other on helping parents lose weight themselves. Both groups included teen…

This study tested whether giving extra support—like cooking classes, motivational talks, and financial help for physical activity—to overweight teens from less advantaged backgrounds helps them manage their weight as well as standard care helps teens from more advantaged backgrou…

This study tested an online personalized program for pregnant women with obesity to help them gain the right amount of weight and reduce the need for delivery interventions like C-sections or forceps. Over 800 women participated, using a secure website to communicate with dietiti…

This study tested whether topiramate, a drug usually used for seizures, can help severely obese children and teenagers lose weight. 18 participants aged 9 to 17 took either topiramate or a placebo for 9 months. The main goal was to see if the drug could lower their Body Mass Inde…

This study tested whether providing medically tailored meals, with or without weekly group support sessions, helps Black adults with high blood pressure, type 2 diabetes, obesity, or metabolic syndrome improve their health. 75 participants received either meals alone, meals plus …

This completed phase 3 trial tested two injectable weight loss drugs, tirzepatide and semaglutide, in 751 adults with obesity or overweight who also had weight-related health problems like high blood pressure. The study lasted about 74 weeks and measured how much weight participa…

This study tested whether taking sodium butyrate tablets for 12 weeks, along with a modestly reduced-calorie diet, helps overweight or obese adults (with or without type 2 diabetes) lose more weight and improve blood sugar and fat levels compared to a placebo. 46 participants wer…

This completed study tested whether the diabetes drug semaglutide (Rybelsus) could help 60 adolescent girls with PCOS and obesity reduce liver fat and improve insulin sensitivity, compared to a weight loss diet. Participants took a daily oral tablet for 4 months or followed a pre…

This completed study looked at how three different diet plans—Mediterranean diet, time-restricted feeding (a form of intermittent fasting), and a standard diet—affect eating behavior and weight management in 75 overweight or obese adults aged 20-49. Researchers measured body comp…

This study looked at whether teaching women about the Mediterranean diet and sustainable nutrition could help them lose weight and improve body measurements like BMI and body fat. Sixty-two women with overweight or obesity took part. The goal was to see if this education leads to…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study tested whether using technology for remote check-ins helps obese teenagers lose weight better than standard in-person visits. 91 teens aged 11-17 took part. The main goal was to see if their body mass index (BMI) improved after 15 months.

This study looked at whether giving vitamin D supplements to obese teenagers, along with a healthy diet and exercise program, could improve how well their blood vessels work. 49 teens took either vitamin D or a placebo for 90 days. The main goal was to see changes in blood vessel…

This study tested a smartphone app called ANíMATE designed to help people with obesity better manage their weight and health. 36 adults with obesity used the app for 16 weeks alongside standard care, while a control group received standard care alone. The goal was to see if the a…

This study tested whether an 8-week circuit exercise program could improve markers of inflammation in overweight young women. Twenty-two women aged 20-30 were randomly assigned to either the exercise program or their usual routine. The exercise group showed increases in a benefic…

This study tested a lifestyle program called HEALTH, which teaches healthy eating and active living through home visits, to help overweight mothers prevent weight gain and lose weight. Over 600 participants took part in this Phase 3 trial. The program was delivered by trained par…

Researchers are testing whether a standard MRI scanner can be used to create detailed 3D maps of fat molecules in the breast. The idea is that changes in fat composition may appear before cancer develops, so this could help detect very early breast cancers. The study will compare…

This study explores whether wearable motion sensors can improve screening for fall risk in people with chronic conditions like osteoarthritis, Parkinson's disease, COPD, and obesity. Participants will perform two standard walking tests while wearing small sensors that measure mov…

This study aims to define normal pressure thresholds during a straight leg raise maneuver in high-resolution manometry to predict acid reflux in obese patients. Researchers will analyze data from 150 obese patients undergoing preoperative assessment for bariatric surgery. The goa…

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver disease and its severe form, NASH, without needing a liver biopsy. Researchers enrolled 158 people at high risk for metabolic syndrome. The LLIFT test combines patient information lik…

Women with class III obesity who gain too much weight during pregnancy face higher risks of diabetes, high blood pressure, cesarean delivery, and larger babies. Standard prenatal care often does not include nutrition counseling based on weight. This trial tests whether adding gro…

Researchers in Shangrao, China, are testing whether short exercise videos played during school breaks can increase physical activity and improve attitudes toward exercise in overweight and obese children aged 9 to 15. About 100 participants are randomly assigned to either follow …

This study tested whether adding a special 'pre-session'—which includes education about diabetes risks, motivational interviewing, and help solving barriers—could encourage more people to attend a national diabetes prevention program. The trial involved 483 adults at risk for dia…

This study tested whether encouraging water instead of sugary drinks in childcare centers helps prevent obesity in young children. Over 1,000 preschool-age children and their families took part. The program included better access to healthy drinks at daycare, plus education and c…

This study is testing whether following a Mediterranean diet during pregnancy can reduce the chance of children developing allergies by age 2. Researchers are enrolling 276 healthy pregnant women (ages 20-35) who are at risk of having a baby with allergies. Participants receive p…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

This study tests whether using smaller or opaque bottles can help prevent rapid weight gain in newborns. Researchers will give 5 infants special bottles and track their weight and feeding habits over 4 months. The goal is to find simple ways to reduce the risk of childhood obesit…

This pilot study tests whether storytelling videos and group discussions can help parents of 2- to 4-year-olds adopt responsive feeding practices—like recognizing when a child is full—to prevent obesity. Researchers will compare three approaches: a simple handout, online videos, …

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study tests a summer garden program called 'Summer Harvest Adventure' for children aged 8 to 11 from low-resource communities. The program teaches nutrition and healthy habits through gardening and cooking activities. Researchers will measure changes in fruit and vegetable i…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested whether a single infusion of zoledronic acid can prevent bone and muscle loss in adults aged 35 and older who are undergoing bariatric surgery. Fifty-nine participants were randomly assigned to receive either the drug or a placebo. The main goal was to measure c…

This study looked at whether a Mediterranean diet, weight loss, or both could lower colorectal cancer risk in 180 obese African Americans aged 45-75. Participants followed one of four plans for six months, and researchers measured changes in bile acids, gut bacteria, and cell act…

This study tested whether giving extra health coaching to new parents—especially fathers—could help prevent rapid weight gain in babies and reduce obesity risk. Researchers enrolled 657 parents from Massachusetts General Hospital and randomly assigned them to either receive coach…

This completed study tested a program called HomeStyles-2, which aims to help parents of children aged 6 to 11 create healthier home environments. The program focuses on improving diet, physical activity, and sleep habits to prevent obesity. Over 450 families participated, with s…

This pilot study tested whether adding health literacy lessons to an obesity prevention program helps teenagers eat healthier and be more active. 36 adolescents aged 13-16 took part. The program taught them how to find, understand, and use health information to make better choice…

This study tested a program that helps families build healthier habits to prevent obesity in children. It involved 48 fourth-graders and their mothers. The program focused on nutrition and physical activity to lower body mass index (BMI) and reduce obesity risk factors.

This completed study tested a school-based program to prevent obesity in over 1,100 preschool children in South Texas. The program included nutrition education and physical activity encouragement. Researchers measured changes in BMI, fruit and vegetable intake, and fitness levels…

This study tested whether a health education program that focuses on reducing sugary drinks and juices, plus providing bottled water at home, can lower obesity risk in Hispanic mothers and their infants. Over 200 mother-infant pairs were randomly assigned to one of three groups: …

This study tested a school program called 'High Five!' to see if it could help prevent overweight and obesity in children aged 7 to 9. Over 650 children took part in fun lessons about healthy eating, physical activity, screen time, and sleep. The program also involved parents to …

This study tested a 12-week wellness program for 98 overweight university employees. The program included brisk walking, nutrition education, and a mobile app for self-monitoring. Researchers measured changes in body fat, muscle mass, waist size, and fitness. The goal was to see …

This study tested a program to help pregnant women with overweight or obesity avoid gaining too much weight. The program included setting goals, tracking weight, learning skills, and getting support from WIC counselors. 416 women from Philadelphia WIC took part, and researchers m…

This study tested a 6-month home-based program for 300 children ages 2–6 who were overweight or obese. Community health workers visited families to encourage healthy eating, physical activity, and parenting skills. The goal was to see if the program could improve children's weigh…

This study tested whether a mindfulness-based training program could help adults who had lost weight keep it off. 48 participants, including those who had bariatric surgery or lost weight through medical or lifestyle programs, took part. The goal was to see if focusing on eating …

This study looked at whether an educational program for pregnant women who are overweight or obese could help prevent their babies from gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits. The goal was to reduce th…

Nausea and vomiting are common after bariatric surgery, and researchers want to know whether a simple cold compress can help. In this trial, 60 adults having weight-loss surgery receive a gauze-wrapped cold pack on the upper neck for five minutes, and care teams rate their nausea…

This pilot study tests a new group program called Move Healthier, designed to help people with overweight or obesity increase their exercise using cognitive and behavioral skills. The goal is to see if it boosts physical activity without raising the risk of disordered eating. Onl…

Obese patients with a BMI over 35 face higher risks when they need a breathing tube for surgery. This trial compares two ways to give extra oxygen beforehand: high-flow oxygen through a nose tube (Optiflow) and BiPAP through a face mask. Researchers will measure oxygen levels at …

This study looked at whether an 8-week Pilates exercise program could improve breathing in overweight and obese women. 54 women were split into an exercise group and a control group. The exercises focused on core strength and abdominal endurance. Researchers measured lung functio…

Researchers at UC Davis are comparing two pain-control plans for women having weight-loss surgery. One group receives standard opioid-based care, while the other gets a mix of non-narcotic medicines with opioids available only if needed. The trial measures pain scores and how muc…

Bariatric surgery helps people with severe obesity lose weight, but it also strips away muscle and bone. Many men who have the surgery also have low testosterone, which worsens muscle loss. This trial tests whether testosterone replacement, combined with exercise and diet counsel…

Researchers are testing whether nicotinamide riboside, a form of vitamin B3 sold as a supplement, can reduce immune system activation in people with mild to moderate psoriasis. The trial enrolls adults aged 18 to 80 who are not on biologic therapy. Participants take either the su…

This trial tests whether injecting a local anesthetic called ropivacaine into the abdominal wall during gastric bypass surgery can reduce the need for opioid painkillers in the first 24 hours after the operation. Half of the 148 participants receive the nerve block, while the oth…

This study tested two video-guided devices (CMAC D-Blade and CMAC Video Stylet) in 150 obese adults undergoing bariatric surgery. The goal was to see which device allows doctors to place a breathing tube more easily and safely on the first try. Participants had a higher risk of d…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This trial tests whether a smartphone app can help people with obesity take a more active role in their care around bariatric (weight-loss) surgery. The app helps users track diet and exercise, report problems, and organize medical documents, with a nurse available to connect the…

This study tests whether training the muscles you use to breathe can improve how long obese breast cancer survivors can exercise. Researchers will compare breathing exercises plus aerobic exercise to aerobic exercise alone in 78 women who finished treatment. The goal is to see if…

This trial tests whether a continuous infusion of the local anesthetic ropivacaine, delivered through small catheters placed near the breastbone, can improve recovery after cardiac surgery. The study focuses on patients at higher risk of respiratory complications, such as older a…

This study looked at whether limiting eating to a 6- or 10-hour window each day helps adults who recently lost weight keep it off. 29 participants were randomly assigned to one of two time-restricted eating plans for 12 weeks. The goal was to see if this approach is practical and…

This study compared two ways to find the right spot for spinal anesthesia in 100 obese women having C-sections. One group used ultrasound to guide the needle, the other used traditional touch-based landmarks. The goal was to see which method leads to a successful first attempt, r…

This study compares two types of stitches used during robotic gastric bypass surgery for weight loss. About 150 adults with severe obesity will be randomly assigned to receive either a special barbed suture or a standard one. The main goal is to see which stitch is faster to use …

This study tested whether taking 1,000 mg of glycine daily for six months could improve memory and thinking in older adults. Fifty-nine participants took the supplement, and researchers measured changes in a brain health marker and cognitive test scores. The goal was to see if th…

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, func…

This study tested whether a 12-week home-based circuit training program could improve blood vessel function and metabolism in adults with obesity. Twenty-nine participants were randomly assigned to either the exercise group or a control group that continued their usual activities…

This study tested whether a dietary supplement called NatureU Burn, made from African mango seed extract and inulin, can increase feelings of fullness after a sugary drink. Fourteen healthy adults took either glucose alone or glucose plus the supplement, then rated their fullness…

This study tested a 6-week group program combining nutrition education with psychological sessions based on Well-Being Therapy in 50 adults with obesity. The goal was to see if improving mental health could lead to healthier, more sustainable eating and weight loss. Participants …

This study looked at whether standing on a vibrating platform while doing foot exercises could improve ankle strength, balance, and body awareness in overweight and obese young adults. Twenty-six people took part in supervised sessions three times a week for eight weeks. The resu…

This study tested two anesthesia approaches for gastric sleeve surgery in 96 patients. One group received standard opioids, while the other also got ketamine. Researchers measured how much opioid pain medicine patients needed after surgery and their pain levels. The goal was to s…

This study tested a new hand position called the 'hook technique' to see if it helps doctors give oxygen more effectively to obese patients (BMI 30-40) using one hand. 375 adults took part, and the researchers measured chest rise, oxygen levels, and other signs of good breathing.…

This pilot study tested whether a remote digital exercise program (Vitala app) is feasible and helpful for adults with obesity and poorly controlled asthma. Twenty participants received a tailored exercise prescription and were encouraged to complete 150 minutes of activity per w…

This study tested whether a commercial meal replacement weight loss programme could reduce atrial fibrillation (AF) symptoms in overweight adults aged 60-85 with persistent AF. 119 participants were randomly assigned to either the weight loss programme or usual care for 32-36 wee…

This study tested if using warm saline (body temperature) to rinse the stomach staple line during laparoscopic sleeve gastrectomy could reduce early bleeding after surgery. 200 adults having weight-loss surgery were randomly assigned to receive either warm or room-temperature sal…

This study looked at whether adding mindfulness and acceptance skills to standard weight loss counseling helps people lose more weight. 276 adults with overweight or obesity participated. Researchers tested three specific skills: awareness, acceptance, and values clarity, to see …

This study tested whether a mobile app (Care4Today®) helps people with severe obesity lose weight before gastric bypass surgery. 142 adults used either the app or standard care. The goal was to see if the app leads to more weight loss and better patient knowledge and satisfaction…

This study tested whether giving lidocaine through a vein during weight-loss surgery helps patients recover faster and need less strong pain medicine. 180 adults scheduled for bariatric surgery received either lidocaine or a placebo (salt water). Researchers measured how much pai…

This study looked at whether walking downstairs is a good exercise for obese women who don't exercise much. Twenty-four women did stair walking twice a week for 8 weeks. The researchers measured changes in cholesterol, blood sugar, and body fat to see if this simple activity coul…

This study tested whether a special turmeric supplement (MERIVA®) could improve memory and thinking in older adults with metabolic syndrome. 85 people took either the supplement or a placebo for 6 months. Researchers measured changes in cognitive tests to see if turmeric helped p…

This small study tested whether gummy candies made with maqui berry could help overweight adults control their blood sugar after eating a carb-rich meal. Ten participants ate white bread alone, or with maqui berry gummies, and had their blood sugar and antioxidant levels measured…

This study looked at whether dry needling, a treatment where thin needles are inserted into muscles, can improve insulin resistance in obese women who have gone through menopause. 52 women took part. The main goal was to see if the treatment lowered a key measure of insulin resis…

This phase 3 study tested a weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it reduces knee pain and helps with weight loss. Participants received either the drug or a placebo for about…

This study tested whether a 12-month weight loss program delivered by smartphone, using behavioral economics tricks, could help economically disadvantaged adults lose weight. 195 participants with obesity and low income were split into two groups: one got the standard mobile prog…

This study looked at whether a supervised exercise program done twice a week for 12 months could improve physical health and mental well-being in women aged 60 and older. 108 women took part, with half doing the exercise program and the other half continuing their usual activitie…

This study tested whether a short therapy program before weight-loss surgery helps patients develop healthier eating habits. About 94 adults preparing for bariatric surgery took part. The goal was to see if the program could improve long-term results by addressing emotional eatin…

This study looked at whether GLP-1 analogues (like Ozempic or Wegovy) combined with lifestyle changes can improve sexual desire in overweight or obese men and women. 85 participants were followed to measure changes in sexual thoughts, activity, and overall sexual health. The goal…

This study tested a 20-week program for teens ages 13-17 who struggle with weight stigma and negative feelings about their weight. The goal was to see if the program was acceptable and helpful when added to a standard weight management program. 17 teens took part, and researchers…

This study tested a new mindful eating program designed for French adults with overweight or obesity. Fifty-six participants joined group sessions and home exercises to improve their eating awareness. The goal was to see if the program could increase mindful eating and reduce anx…

This study looked at the safety of giving lidocaine through a vein during weight-loss surgery. Fifty adults having laparoscopic bariatric surgery received lidocaine, and their blood levels were measured at several points. The goal was to confirm that using a dose based on adjuste…

This completed Phase 1 trial tested whether MitoQ, a drug that targets cell energy centers, can improve airway reactivity in 47 obese adults with poorly controlled asthma. Participants took MitoQ or a placebo daily for 12 weeks. The study aimed to see if MitoQ could help control …

This study looked at whether a weekly injection of semaglutide (a medicine also used for weight loss) can improve heart failure symptoms and daily function in people with obesity-related heart failure. 529 adults with a BMI of 30 or higher took part. Participants received either …

This pilot study tested an online guided self-help program for teens aged 12–17 who binge eat and have a higher weight. Eight teens completed weekly online sessions over four months. The main goal was to see if the program was practical and acceptable, not to measure effectivenes…

This study looked at whether an effort rehabilitation program could improve quality of life and interest in physical activity for overweight or obese children and teens. 47 participants who had trouble exercising due to their weight joined the program. Researchers measured change…

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe or morbid obesity reduce their food addiction. 154 participants received either 12 therapy sessions over 18 weeks or their usual care. The goal was to see if the therapy cou…

This study tested whether training local community members as wellness coaches could help African American adults in economically disadvantaged areas manage their weight. Researchers recruited and trained coaches to lead a 12-week group lifestyle program. The goal was to see if t…

This study looked at whether high-intensity interval training (HIIT) or weight-loss surgery can reduce the risk of nerve damage (peripheral neuropathy) in people with obesity. About 140 adults who were candidates for bariatric surgery took part. Researchers measured nerve health …

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

Researchers surveyed 751 high school students aged 15 to 17 in Istanbul to see how obesity awareness relates to weight status and daily habits. Students answered questionnaires about diet, physical activity, screen time, sleep, and family background, and researchers measured thei…

This completed study looked at how lean and obese individuals respond to thirst and water deprivation. Researchers gave 75 healthy men a high-salt infusion and a 24-hour water fast, measuring their thirst, hormone levels, and water intake. The goal was to understand if body fat a…

This study looked at how people with and without non-alcoholic fatty liver disease (NAFLD) process food. Researchers monitored 53 adults over two days, measuring metabolism, blood, and urine after meals. The goal was to find differences that might explain why fat builds up in the…

This completed study investigated how eating behaviors and food preferences, especially for high-fat foods, contribute to obesity. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake mea…

Researchers are studying how metabolic and bariatric surgery changes fat metabolism and a type of immune cell called myeloid-derived suppressor cells in women with obesity. The study compares blood and tissue samples from women before and after surgery to see if these changes rel…

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

This study aims to understand why some people gain or lose weight more easily than others. Researchers will measure how the body's energy use changes during overeating and dieting in 83 healthy adults. Participants will stay in the hospital for 10 weeks, undergoing tests like met…

Researchers want to know whether two genes, PCSK9 and FXR, help cause the combination of insulin resistance and abnormal blood fats that often comes with obesity. The study enrolls 111 adults with a high body mass index who are scheduled for bariatric surgery. During surgery, doc…

Researchers are comparing two sessions of high-intensity interval training on a stationary bike in adults with overweight or obesity. In one session, participants breathe air with less oxygen than normal; in the other, they breathe regular air. The study measures oxygen use, fat …

Researchers at the University at Buffalo are studying whether insulin can reduce inflammation by suppressing toll-like receptors, which are part of the body's immune alarm system. The trial compares insulin infusion with dextrose and saline infusions in three groups: lean healthy…

This study used ultrasound to measure the optic nerve sheath (the lining around the eye nerve) in 56 adults having laparoscopic bariatric surgery. The goal was to see how brain pressure changes during surgery due to gas inflation and body positioning. No drug or treatment was tes…

Weight-loss surgery like sleeve gastrectomy can cause significant muscle loss, not just fat loss. This study follows 110 adults for 18 months after surgery to see how muscle mass changes and whether certain blood markers, called myomiRs, along with routine lab tests, can track th…

This study follows 160 people for 12 months after laparoscopic sleeve gastrectomy to measure changes in two hormones made by fat tissue: asprosin and neuregulin 4. Asprosin rises with obesity and insulin resistance, while neuregulin 4 falls, and researchers want to see if their s…

This study is testing whether following a Mediterranean-style diet based on U.S. dietary guidelines improves heart health more when combined with weight loss. Researchers will provide all meals for 70 adults with obesity or excess body fat for eight weeks. Participants will be sp…

This study looks back at the records of adults who had surgery for gunshot wounds to the abdomen or chest and abdomen. Researchers compare patients with obesity, defined by a body mass index of 30 or higher, to those without obesity. They track complications, time in the intensiv…

The body releases insulin in pulses, but the standard test for insulin sensitivity uses a steady drip. This study compares the usual continuous insulin infusion with one given in pulses every five minutes, using the same total amount of insulin. Researchers want to see if the pul…

Researchers are testing whether two types of bariatric surgery, Roux-en-Y gastric bypass and sleeve gastrectomy, reduce how much dietary protein older adults digest. The study compares adults aged 65 and older who had surgery 1 to 10 years ago with younger adults and with people …

This study tested whether a very low energy diet (800 calories a day using meal replacements) before pregnancy could improve the health of obese women and their babies. 147 women participated, including those with obesity and healthy-weight women for comparison. Researchers measu…

This study looks at stomach tissue from 100 obese patients undergoing weight-loss surgery and compares it to tissue from lean individuals. Researchers are counting immune cells called macrophages and mast cells, as well as blood vessel density, to see if obesity-related inflammat…

This study compares two diets in people with overweight and early signs of blood sugar problems: a low-carbohydrate diet and a Mediterranean diet, both designed to produce similar weight loss. Each participant follows both diets for four weeks, in random order, with a break in be…

This study looks at how packaging with warning labels and cartoon characters influences what Colombian teens aged 12 to 17 think about buying and eating ultraprocessed foods. About 1,960 teens will view different product images online and answer questions about how likely they ar…

This study looks at how changing sleep patterns affects eating behavior and self-control in 120 children who are overweight or at risk for obesity. Researchers will monitor sleep, brain activity, and real-world eating to understand the link between sleep and weight gain. The goal…

Researchers are investigating whether eating ultra-processed foods is linked to obesity and metabolic syndrome in children and teens. The study will compare three groups: children with obesity, children with obesity plus metabolic syndrome, and healthy controls. Participants will…

This study tests whether giving people special supplements designed for their type of weight-loss surgery can help keep their vitamin levels healthy. After bariatric surgery, the body absorbs nutrients differently, which can lead to both deficiencies and, from too many supplement…

This observational study looks at health data from about 10 million U.S. birth records to find the safest amount of weight gain during pregnancy for women with obesity. Current guidelines recommend the same 5 to 9 kg gain for all, but obesity has different levels of severity. Res…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This clinical trial is testing a medical device that has not been approved or cleared by the U.S. FDA. The specific purpose, who can join, and how the device works are not publicly available. Because key details are withheld, it is not possible to describe the expected benefits o…

This study looks at why babies born with restricted growth (IUGR) have a higher risk of childhood obesity. Researchers will track 400 mother-infant pairs for two years, analyzing T-cell changes and DNA methylation. The goal is to uncover early biological signs that could lead to …

This study looked at 155 adults who had weight-loss surgery to see if using a low-flow or standard-flow anesthesia gas changed inflammation levels in the body. Researchers measured blood markers like CRP before and after surgery. The goal was to learn more about how anesthesia af…

This study looks at why some children are less affected by food advertising than others. Researchers will use brain scans and eating tests in 200 kids aged 7-9 to find traits that protect against overeating. The goal is to understand what makes certain children resilient to food-…

This study looked at how the drug topiramate works in teenagers with severe obesity. Researchers wanted to understand why some teens lose weight while others don't, by measuring drug levels in the blood. The goal is to eventually personalize dosing for better results.

This study follows adolescents with youth-onset type 2 diabetes, along with obese and lean peers, into young adulthood to see how their kidneys change over time. Using advanced imaging and kidney function tests, researchers aim to understand early signs of diabetic kidney disease…

This study investigates whether visceral (belly) fat cells age more quickly than other fat tissue in people with severe obesity, and whether that accelerated aging contributes to conditions like diabetes and heart disease. Researchers will analyze fat samples from about 186 adult…

This study looks at how a high-protein drink versus a high-carbohydrate drink influences what people choose to eat afterward. Researchers will test 45 adults with normal weight, overweight, or obesity to see if the type of meal changes their 'food memory' and calorie intake. The …

This study looks at how a protein called FABP4, which is linked to fat metabolism, changes in the blood after Roux-en-Y gastric bypass surgery. Researchers are following 28 adults who had the surgery, measuring FABP4 levels along with weight, body composition, inflammation, and g…

This study uses advanced MRI scans to see if bariatric surgery (weight-loss surgery) can improve the health of the pancreas in people with severe obesity. Researchers will scan the pancreas before surgery and again six months after, measuring fat content, tissue stiffness, and ot…

This study looks at how weight loss surgery (gastric sleeve) affects exercise ability in people with or at risk for heart failure with preserved ejection fraction (HFpEF). Researchers will measure oxygen use during exercise before and 12 months after surgery. The goal is to under…

This trial investigates how replacing animal proteins with plant proteins in the diet influences metabolism. Adults with early signs of metabolic syndrome (like high triglycerides or slightly elevated blood pressure) will follow a controlled diet for four weeks, either predominan…

This trial investigates how different ways of creating an energy deficit affect appetite and food intake in adolescents with obesity. Participants will experience three conditions: exercise combined with dietary restriction, dietary restriction alone, and a rest control. Research…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study investigates how obesity treatments, such as bariatric surgery or medication, influence food purchasing habits in daily life. Researchers will collect digital receipts from loyalty cards and have participants fill out questionnaires over several years. By analyzing the…

This study explores how weight-loss surgery changes the body's protein needs and whether fast-absorbing milk proteins can help preserve muscle mass and strength. Researchers will measure nitrogen balance and muscle function in 25 adults with severe obesity before and after gastri…

This study looks at how the body's energy use changes during weight loss and regain in adolescents with obesity. Researchers will track resting and exercise energy expenditure, body composition, and food preferences in 40 teens aged 12-16 over a 12-month behavioral program. The g…

This study looks at whether a single 30-minute cycling session can alter how adolescents with obesity experience hunger and food reward after a fixed meal. Researchers will measure appetite feelings, food preferences, and how much they eat at a later dinner. The goal is to unders…

This trial compares how burning calories through exercise versus cutting calories through diet affects appetite and food intake in adolescents with obesity. Participants (aged 12-16) will undergo both conditions—an exercise session and a dietary restriction—and their hunger, food…

This study looks at how a 12-week weight loss program—combining nutrition advice, exercise, and psychological support—changes the way teenagers with obesity burn energy. Researchers want to understand the separate roles of metabolic and mechanical load on energy expenditure durin…

This study looks at how two different ways of managing pain after laparoscopic sleeve gastrectomy affect lung function. One method uses an epidural catheter to deliver numbing medicine near the spine, while the other uses pain medicine given through an IV. Researchers measure bre…

This study looks at how common dissociative tendencies are in adults with obesity who are seeking medical or surgical help for the first time. Participants fill out questionnaires that measure dissociation, eating behaviors, and other related factors. The goal is to better unders…

This study investigates whether short-term diet changes cause inflammation in the hypothalamus, a brain region that controls body weight. Overweight adults aged 20-40 eat specially prepared meals for 14 days, alternating between high- and low-calorie periods. Researchers use MRI …

This study looks at whether two popular weight-loss medications, semaglutide and tirzepatide, can improve early signs of liver damage in people with overweight or obesity. Researchers measured changes in liver health markers after at least 12 weeks of treatment in 154 adults. The…

This study looked at whether placing patients in a specific position (head up, feet down) before starting laparoscopic weight-loss surgery could reduce pressure on the brain. Researchers measured the optic nerve sheath diameter, an indicator of brain pressure, in 90 patients. The…

This study looks at how aging changes the way older adults respond to exercise. Researchers will have 26 people who previously completed a structured exercise program do a 6-month aerobic workout. They will measure changes in insulin sensitivity and heart fitness to see if age af…

This completed pilot study examined how fat tissue dysfunction contributes to type 2 diabetes risk in overweight men from South Asian, Black African/Caribbean, and White European backgrounds. Researchers used MRI scans and blood tests to measure fat distribution, inflammation, an…

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study looked at 40 adults who had sleeve gastrectomy surgery for obesity. Researchers measured blood levels of fractalkine, a protein involved in inflammation, before and three months after surgery. The goal was to see how fractalkine levels change and whether those changes …

This study tested whether raising ketone levels—either through a ketogenic diet or a ketone supplement—can improve markers of obesity-related disease risk in overweight adults. Sixty-nine participants followed either a keto diet or took a ketone drink for four weeks. Researchers …

This study looked at 255 people with severe obesity who had weight-loss surgery. Researchers wanted to see if losing weight could improve liver scarring (fibrosis) by measuring certain blood tests before and one year after surgery. The goal was to understand how weight loss affec…

This study looked at how Enneagram personality types are connected to body weight, eating behaviors, emotional eating, and overall well-being in 210 adults. Participants completed questionnaires about their personality, eating habits, and mental health. The goal was to better und…

This study looked at how often people eat and whether it affects weight loss. Researchers followed 30 overweight adults aged 18 to 65. They tracked eating habits, calories, and weight to better understand the link between meal timing and losing weight.

This study looked at whether eating foods with fewer calories per bite (low energy density) helps people lose weight. Sixty adults with overweight or obesity followed a 12-week lifestyle program. Researchers tracked what they ate, how full they felt, and weight changes to find th…

This study looked at how certain gut hormones change after eating a standard meal in 80 adults aged 40-60 with different body weights. Researchers measured hormones like GLP-1 and GIP, which help control appetite and blood sugar. The goal was to understand how these hormone respo…

This study looked at how obesity affects the way children's bodies process common acid reflux medications like lansoprazole and pantoprazole. Researchers gave a single dose of these drugs to 76 children aged 6-21, both with and without obesity, and measured how long the drugs sta…

This study looked at how bariatric surgery affects taste receptors and taste perception in 20 obese patients. Researchers measured changes in taste before and 6 months after surgery. The goal was to understand why taste changes happen after weight loss surgery.

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This study used MRI to examine how the brain and gut communicate after eating different types of drinks in people with obesity and healthy weight. Researchers gave participants a high-fat drink or a carbohydrate drink and scanned their brains and stomachs. The goal was to develop…

This completed study followed 687 people who had bariatric surgery (gastric bypass or sleeve gastrectomy) in Norwegian public hospitals between 2010 and 2015. Researchers aimed to see how long weight loss lasts and whether related health problems like diabetes, high blood pressur…

This study looked at whether saliva can be used to measure endocannabinoids—natural chemicals linked to appetite and weight—instead of taking blood. Researchers compared 12 obese and 12 normal-weight adults after fasting. The goal was to see if saliva levels differ between the gr…

This study looked at whether stress hormones (glucocorticoids) released after eating contribute to fat gain in overweight people. Twenty-three overweight men were given either a drug combination that blocks these hormones or a placebo while overeating for a week. Researchers meas…

This study looked at 216 women aged 18-45 to see if weight affects bladder symptoms, hygiene habits, and body awareness. Researchers compared normal-weight women to those who are overweight or obese using questionnaires. The goal was to understand how these factors relate and to …

This study measured levels of a hormone called pregnenolone and related compounds in the blood of 25 men—some with obesity and some at a healthy weight. Researchers wanted to see if a breakdown in the body's natural feedback loop might lead to overactivity of the endocannabinoid …

This study looked at how the body's natural endocannabinoids (similar to cannabis compounds) interact with the stress hormone cortisol in people with Cushing's syndrome, a condition of high cortisol. Researchers measured blood levels of these compounds in 40 participants, includi…

This study tested whether using a special breath test (indirect calorimetry) can help doctors give the right amount of nutrition to critically ill patients with obesity who are on breathing machines. The study involved 60 adults from intensive care units in Australia and New Zeal…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked at how eating a high-fat diet for 5 days affects inflammation in older adults (ages 50-79) with normal weight or obesity. Researchers measured blood markers and gut bacteria to see if a high-fat diet causes more inflammation than a low-fat diet. The goal was to …

This study tested whether a protein from amaranth (a plant) could change the gut bacteria in children with overweight or obesity. 56 children took part, and researchers measured their gut bacteria and blood markers. The goal was to learn more, not to treat or cure the condition.

This study looked at 37 obese adults to understand why the brain's pleasure response to food is weaker in obesity. Researchers tested if insulin resistance in the brain causes this reduced response and if weight loss can improve it. The goal is to learn why weight loss is hard an…

This study tested whether a 6-month high-intensity functional training program is feasible and helpful for overweight or obese adults with long-term mobility disabilities. Twenty-five participants did exercise sessions three times a week. The goal was to see if the program could …

This study looked at 116 overweight or moderately obese adults who had a procedure called endoscopic sleeve gastroplasty to help them lose weight. The goal was to find out why some people lose more weight than others after the procedure. Researchers checked blood samples and medi…

This study tested a new computer algorithm that uses data from wearable sensors and food diaries to predict a person's real-time risk of developing prediabetes. 77 overweight or obese adults wore glucose monitors and fitness trackers for 4 months. The goal was to collect data to …

This study looked at 90 children and teens (ages 7-18) taking antipsychotic medication to see how it affects their hormones, growth, and metabolism. Researchers measured prolactin levels and checked for links to sex hormones, metabolic health, and puberty development. The goal wa…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study looked at 195 overweight or obese pregnant women to understand what factors influence their decision to join a 12-week program combining nutritional counseling and physical activity. The program included three diet workshops and weekly exercise sessions. Researchers an…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study looked at how physical activity relates to quality of life and mental health in 38 adults with severe obesity (BMI over 40). Participants wore activity monitors for 6 weeks to track sitting, standing, and movement. The goal was to see if simply monitoring activity coul…

This completed study collected neck tissue, blood, and urine from 34 adults having neck surgery. The samples are stored in a central bank for researchers to study obesity and diabetes. The goal is to help scientists learn more about these conditions and find new ways to predict, …

This study looked at how a 12-week exercise program affects body composition and metabolism in women who had sleeve gastrectomy surgery at least 3 months earlier. Twenty women participated, doing either aerobic exercise alone or a mix of aerobic and strength training. The goal wa…

This study looked at 76 children aged 8-10 from rural areas to understand why some stay at a healthy weight despite being surrounded by obesity risks. Researchers measured brain activity, eating habits, and body fat to see how kids learn from food cues. The goal is to find factor…

This study looked at how a 20% calorie-restricted diet changes metabolism in obese men of two age groups: 30-40 and 60-70 years old. Researchers measured fat breakdown at rest and during exercise, along with genetic markers in muscle and fat tissue. The goal was to understand if …

This study collected blood, stomach, liver, intestine, and fat tissue from 360 severely obese patients undergoing bariatric surgery. The goal was to better understand how obesity and surgery affect the body, especially the digestive system. Researchers hope this knowledge will le…

This study combines data from four earlier trials to track 262 adults with type 2 diabetes and obesity for up to 13 years. Researchers want to see if bariatric surgery keeps blood sugar under control longer than medical or lifestyle changes. Participants were originally in random…

This completed study looked at 128 adults with obesity to understand how blood sugar levels, gut bacteria, and brain iron deposits are connected to thinking skills. Some participants followed a diet or had bariatric surgery, but the goal was to observe changes over one year, not …

This completed study looked at 61 adults to see if physical fitness, body composition, and diet are linked to gum disease severity. Researchers reviewed dental records and lifestyle questionnaires from a previous study. No new treatments were tested; the goal was simply to unders…

This completed study looked at whether eating only during a specific daily window (time-restricted eating) can slow the aging process in 176 adults who are overweight or have early fatty liver disease. Participants followed a Mediterranean diet with or without calorie restriction…

This study tested whether a medical body composition scale (mBCA 555) could pick up early changes in body fat, muscle, and water balance in 41 overweight adults using L112 lipid-binding products. The goal was to find signs of progress that appear before the scale shows weight los…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This study looked at how two different nutritionally balanced diets affect insulin levels and other markers of metabolic health in 52 adults who are overweight or at risk for diabetes. Participants followed each diet while maintaining their weight, and researchers measured change…

This study looked at whether using a face mask to help obese patients breathe during a short pause in anesthesia makes intubation safer. Over 700 patients with a BMI of 35 or higher took part. The goal was to see which method leads to fewer complications like low oxygen levels or…

This completed study looked at 115 obese patients undergoing hip or heart surgery to see if inflammation in their fat tissue is linked to confusion or memory problems after the operation. Researchers collected blood and fat tissue samples during surgery and tracked patients' thin…

This study looked at 150 adults with normal weight, overweight, or obesity to see if a nutrition plan based on both genes and body measurements works better than one based only on body measurements. Participants followed a six-month diet program, and researchers tracked changes i…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This completed study examined 292 people with non-alcoholic fatty liver disease (NAFLD) to see if liver scarring is linked to heart disease risk. Researchers used non-invasive tests like the coronary calcium score and liver elastography. The goal was to better understand how to s…

This study looked at 30 adults with overweight or obesity and at least one heart risk factor. Researchers wanted to see if losing at least 10% of body weight could improve heart structure and function. They used heart scans and blood tests to measure changes. The goal was to bett…

This study followed 22 adults with obesity who went through a standard diet program, starting with a very-low-calorie diet and then a regular weight loss diet with counseling. Researchers measured weight loss, body fat distribution, glucose metabolism, and inflammation over 12 mo…

This study looked at 1500 people with obesity (BMI 25 or higher) to find out what helps diabetes go away and other health issues improve after weight-loss surgery. Researchers collected health data before and after surgery, including weight, blood sugar, and quality of life. The …

This study looked at how a 10-day low-calorie diet, combined with either low or moderate carbohydrate intake, affects exercise ability and health in overweight but otherwise healthy women aged 20-35. Thirty-six participants followed the diet and completed cycling tests and blood/…

This completed study looked at how people change their eating habits after starting GLP-1 drugs like Ozempic or Mounjaro for weight or diabetes. Researchers tracked 37 adults using dietary records and questionnaires to see if it's feasible to study diet changes this way. The goal…

This study looked at how eating ultra-processed versus unprocessed foods changes the body's stress hormone (cortisol) levels. Twenty healthy men ate two different meals with the same calories and nutrients, and researchers measured their blood cortisol and other metabolic markers…

This study looked at 106 people with obesity who were scheduled for weight-loss surgery. Researchers measured how their upper airways behaved during sleep and used MRI scans to see if changes after surgery could explain why some develop obstructive sleep apnea and others do not. …

This study looked at how losing weight through diet changes body fat and metabolic health in 74 adults with excess weight. Participants followed a 12-week low-calorie diet. The goal was to see if losing more fat for the same amount of weight loss leads to better health improvemen…

This study created a registry of 3,000 children who were severely obese before age 6. Researchers collected DNA samples to look for genetic causes of early obesity. The goal was to better understand the condition and identify families interested in future clinical trials.

This study followed about 1,900 pregnant women and their babies for two years to see how HIV and the medication dolutegravir affect weight gain and overall metabolic health. Researchers compared women with HIV to those without, and also looked at differences between women who sta…

This study from the University of Pisa examined how a very low calorie ketogenic diet (VLCKD) affects body weight and energy use over time in 17 people with obesity. Participants followed the diet and were then monitored for changes in body composition and 24-hour metabolism. The…

This study tested whether using a breathing training device (PrO2 Fit) four times a week for 8 weeks could improve cardiovascular health and mood in postmenopausal women aged 50-75. Researchers measured how quickly the women's oxygen use responded during exercise and how far they…

This study looked at how much energy obese teenagers burn after eating meals with different calorie amounts. Fifteen teens aged 11 to 17 took part. Researchers measured their energy use and appetite after meals to better understand how the body processes food in obesity.

This study looked at how regular aerobic exercise changes appetite and metabolism in sedentary overweight teenagers. Researchers measured hunger levels and blood markers after a meal, comparing teens who exercised with those who didn't. The goal is to understand if exercise alone…

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This completed study looked at how tirzepatide, a weight-loss drug, works in real-world settings for two groups: people who regained weight after gastric sleeve surgery, and those preparing for obesity surgery. Researchers tracked weight and metabolic changes over 6 months in 254…

This study tested whether adding carob to a Western-style breakfast can help regulate hunger hormones and appetite. Twenty healthy, normal-weight men ate a carob-enriched meal, and researchers measured changes in ghrelin (a hunger hormone) and self-reported fullness. The goal was…

This study tested a program called AARC, designed to support African American families with new babies. The program included 7 group sessions over Zoom covering parenting, feeding, sleep, and self-care. Researchers wanted to see if the program was acceptable and practical for fam…

This study looked at whether a person's genetic risk for obesity affects how much weight they lose on a diet. Researchers recruited 223 overweight adults with either very high or very low genetic risk scores for high body mass index (BMI). Half received diet coaching for 6 months…

This study looked at 320 people with HIV in Chile to understand why they often develop health problems like heart disease and diabetes, even when their HIV is controlled with medication. Researchers collected blood samples and used advanced techniques to measure inflammation and …

This study looked at health data from over 550,000 Chinese adults to see how being overweight or obese affects heart disease. Researchers used national survey information to find out how common heart problems are in this group and how they change over time. No treatments were giv…

This study looked at whether the smallest meaningful change in bone density measurements is different for people with obesity compared to those without. Researchers measured bone density twice in 120 adults with a BMI over 30. The goal was to improve accuracy when using bone scan…

This study created a registry of 200 overweight children and young adults with high blood pressure to track their heart health over time. Researchers collected medical information from clinic visits to understand how weight affects the heart. No treatments or interventions were g…

This completed study tracked 1290 obese adults (BMI 30 or higher) undergoing weight-loss surgery to see how often doctors have trouble placing a breathing tube. The goal was to estimate the rate of difficult airway events and identify patient factors that raise the risk. The find…

This study tested whether motivational interviewing—a therapy that helps people find their own reasons to change—can shift brain activity and food choices in people with food addiction. 56 participants, including those with and without obesity, underwent brain scans while making …

This study looked at how different diet compositions affect the number of calories people burn and their risk for chronic diseases like diabetes and heart disease after losing weight. Over 200 adults with overweight or obesity followed a weight-loss phase, then a weight-maintenan…

This completed study looked at 3602 people who lost weight through surgery or medication to understand why some regain weight. Researchers used questionnaires about diet, exercise, quality of life, and mental health to identify risk factors. The goal is to build a model that pred…

This study looked at how two types of exercise—high-intensity interval training (HIIT) and combined aerobic and strength training—affect health markers in obese women after menopause. Forty-five women were split into three groups: HIIT, combined training, or no exercise. Over 12 …

This study looked at how sleep quality, when people eat, and gut bacteria are linked to obesity. Researchers tested a mobile app to help people make healthier lifestyle changes. The study included 133 adults with different body weights, including some with sleep apnea. The goal w…

This study looked at whether a nutrition and behavior change program could help reduce sleep apnea in people who are overweight or obese. About 400 adults took part, and researchers measured changes in sleep apnea risk, daytime sleepiness, and weight loss. The goal was to see if …

This study looked at how COVID-19 lockdowns changed weight, sleep, and behavior in nearly 4,800 adults already in a weight-loss program in France. Researchers wanted to see if stress, less exercise, and changes in eating habits during confinement slowed weight loss. The study is …

This completed study looked at how the number of meals per day and the timing of energy intake influence gut microbiome composition in both morbidly obese and non-obese adults. Researchers analyzed baseline data from 34 participants (11 non-obese, 23 morbidly obese) to compare th…

This study looked at how gastric bypass surgery changes the bacteria in the small intestine. Researchers measured hydrogen in the breath of 51 severely obese patients before surgery and at several points up to 2 years after. The goal was to find out how often bacterial overgrowth…

This study looked at whether a simple CT scan before weight-loss surgery can help predict when the original surgical plan might need to change during the operation. Researchers reviewed data from 288 adults who had planned gastric bypass surgery, comparing those whose surgery cha…

This study looked at brain activity in 108 women to see if overeating shares features with addiction. Researchers measured brain waves (P300) while women listened to sounds, and also asked about eating habits and mood. The goal was to compare obese women with eating disorders to …

This completed study looked at 60 obese patients who had bariatric surgery (like gastric bypass or sleeve gastrectomy). Researchers checked their gut bacteria and hormone levels before and 6-12 months after surgery. The goal was to see how the microbiome changes and if those chan…

This study looked at whether watching short videos about healthy eating can improve diet quality and confidence in making food choices. 62 adults with overweight or obesity were split into two groups: one watched videos and discussed them, the other received written handouts. The…

This study looked at nearly 20,000 people in Sweden who had sleeve gastrectomy surgery for severe obesity. Researchers analyzed registry data to see how much weight patients lost, how long they kept it off, and whether related health problems like diabetes improved or went away. …

This study looked at how stress hormones (like cortisol) and personality traits (like resilience) influence how people with overweight or obesity feel during short, intense cycling workouts. Thirty-two adults completed a 10-week program of one-minute high-intensity intervals. The…

This study tested a new scoring system called BARSCORE to predict how much vitamin, mineral, and protein supplementation patients need after bariatric surgery. Researchers analyzed data from over 4,500 patients who had surgery between 2015 and 2021. The goal was to create a simpl…

This study used advanced MRI scans to look for organ damage in 693 adults who had recovered from COVID-19. Researchers focused on the heart, kidneys, and liver to see how often and how severely these organs were affected. The goal was to better understand the long-term health imp…

This study looked at 514 people with stable coronary artery disease to see if how their body processes fat after a meal (triglyceride tolerance) is linked to future heart attacks or death. Researchers also checked blood sugar tolerance. The goal was to find a better way to identi…

This study looked at how the blood thinner rivaroxaban behaves in people with severe obesity or after bariatric surgery (gastric bypass or sleeve gastrectomy). Researchers gave 67 participants rivaroxaban daily for 8 days and measured drug levels and blood clotting. The goal is t…

This study looked at how different types of trans fats—one from dairy products and one from processed foods—affect insulin resistance in obese women. Sixty-six participants were given special diets to compare the effects. The goal was to understand if natural trans fats are less …

This study looked at whether a blood marker called PTX3 can predict how well people do after gastric bypass surgery. Researchers followed 23 patients for 6 months after surgery, measuring weight loss, insulin resistance, and inflammation. The goal was to see if PTX3 levels before…

This study examined blood samples and physical measurements from 158 adults aged 55-69 to see if certain immune system patterns are linked to insulin resistance, a condition that can lead to diabetes. Researchers measured various immune cells and markers to find a profile that co…

This study checks on mothers and their children 12 years after a pregnancy lifestyle program. Researchers want to see if healthy eating and activity during pregnancy affect the child's body composition and long-term health. About 497 families from the original TOP study are invit…

This study examined 170 men from couples struggling with infertility to see if metabolic syndrome—a cluster of conditions like high blood pressure, high blood sugar, and abnormal cholesterol—is linked to poor sperm quality. Researchers measured sperm count and other sperm feature…

This study tested a device called ANI that measures pain during weight-loss surgery in 15 adults. The goal was to see if using the monitor helps doctors give less morphine. The study is complete and focused on improving pain control during surgery.

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. 15 adults with overweight or obesity took part. Researchers measured weight, waist size, and heart health over time to understand what helps…

This study looked at how drinking orange juice compared to a sugar-sweetened beverage affects risk factors for heart disease and type 2 diabetes. Fifty-six adults drank either orange juice or a sugary drink for four weeks. Researchers measured changes in cholesterol, blood sugar,…