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New weekly shot shows promise for obesity, knee pain, and sleep apnea

NCT ID NCT05929066

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either the drug or a placebo for about 89 weeks, with some continuing for an extra 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
retatrutide
What this could lead to
If successful, retatrutide could offer a new once-weekly injection for significant weight loss and improvement in related conditions like knee osteoarthritis and sleep apnea.
What could go wrong
This is a completed Phase 3 trial, but results are not yet published. Weight loss drugs can have side effects like nausea or vomiting, and long-term safety is still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

2,335 people

The number who actually took part.

Started

Jul 2023

Finished

Apr 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have body mass index (BMI) ≥30.0 kilograms per square meter (kg/m²), or ≥27.0 kg/m² with at least one of the following: * hypertension * dyslipidemia * obstructive sleep apnea, or * cardiovascular disease * History of at least one unsuccessful dietary effort to reduce body weight GOA1 Inclusion Criteria: * Have index knee pain for \>12 weeks prior to screening, and presence of index knee pain for \>15 days over the previous month * Have knee X-ray with moderate radiographic changes (Kellgren-Lawrence Grade 2 or 3) per central reading at screening * Currently meets American College of Rheumatology (ACR) Criteria (clinical and radiological) for OA. GSA1 Inclusion Criteria: * Previously diagnosed with OSA * Have AHI ≥15 on polysomnography at screening (definition of moderate-to-severe OSA) * For participants not on positive airway pressure (PAP) therapy: unable or unwilling to use PAP therapy and have not used PAP for at least 4 weeks prior to screening. * If on PAP therapy, have been on PAP therapy for at least 3 consecutive months prior to screening, and willing to temporarily stop using PAP therapy for approximately 7 days prior to each of the sleep study (PSG) visits. GZBJ Addenda (2) inclusion criteria: * Have completed the final treatment visit of GZBJ Week 80. Exclusion Criteria: * Have a self-reported or documented change in body weight \>5 kg (11 pounds) within 90 days. * Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening. * Have a prior or planned surgical treatment for obesity. * Have diabetes mellitus. * Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) * Have had pancreatitis. GOA1 exclusion criteria * Have had steroid joint injections within 90 days of screening. * Have had other joint injections and procedures within 6 months of screening. * Have joint disease other than osteoarthritis. GSA1 exclusion criteria * Use stimulants (for example, modafinil, armodafinil, solriamfetol, pitolisant, amphetamine) less than 3 months prior to screening. * Use hypnotics, mirtazapine, opioids, trazodone, and zonisamide less than 3 months prior to screening. * Use a dental appliance or other device to treat OSA other than PAP therapy. GZBJ Addenda (2) exclusion criteria * Have had study intervention discontinuation. * Have had permanent dose reduction.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder obstructive sleep apnea syndrome osteoarthritis, knee Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Obstructive sleep apnea Osteoarthritis, knee Overweight

Contacts and locations

Locations

  • Advanced Research Institute

    Ogden, Utah, 84405, United States

  • Aggarwal and Associates Limited

    Brampton, Ontario, L6T 0G1, Canada

  • Aintree University Hospital NHS Foundation Trust

    Liverpool, United Kingdom, L9 7AL, United Kingdom

  • All India Institute of Medical Sciences

    Bhubaneswar, Odisha, 751019, India

  • Altoona Center For Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Ambulatorium Sp. z o.o.

    Elblag, Warmian-Masurian Voivodeship, 82-300, Poland

  • Arizona Research Center

    Phoenix, Arizona, 85053, United States

  • Arké SMO S.A de C.V

    Veracruz, Veracruz, 91910, Mexico

  • Artemis Institute for Clinical Research

    San Diego, California, 92103, United States

  • Avron Hospitals

    Ahmedabad, Gujarat, 380013, India

  • Barwon Health

    Geelong, Victoria, 3220, Australia

  • Bluewater Clinical Research Group Inc.

    Sarnia, Ontario, N7T 4X3, Canada

  • Brengle Family Medicine

    Indianapolis, Indiana, 46260, United States

  • C.I.C. Mauricie inc.

    Trois-Rivières, Quebec, G8T 7A1, Canada

  • C.M.D.T.A. Neomed

    Brasov, Brașov County, 500283, Romania

  • CEPIC - Centro Paulista de Investigação Clínica

    São Paulo, São Paulo, 04266-010, Brazil

  • CHUAC-Complejo Hospitalario Universitario A Coruña

    A Coruña, A Coruña [La Coruña], 15006, Spain

  • CPCLIN

    São Paulo, São Paulo, 01228-200, Brazil

  • CPQuali Pesquisa Clínica

    São Paulo, São Paulo, 01228-000, Brazil

  • Cabinet Medical Dr.Geru

    Timișoara, Timiș County, 300288, Romania

  • Canadian Phase Onward

    Toronto, Ontario, M3J 0K2, Canada

  • Carteret Medical Group

    Morehead City, North Carolina, 28557, United States

  • CenterMed Lublin NZOZ

    Lublin, Lublin Voivodeship, 20-044, Poland

  • Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative

    Springfield, Illinois, 62711, United States

  • Central Phoenix Medical Clinic

    Phoenix, Arizona, 85020, United States

  • Centre de Recherche Clinique de Laval

    Laval, Quebec, H7T 2P5, Canada

  • Centro de Atención e Investigación Clínica

    Aguascalientes, Aguascalientes, 20119, Mexico

  • Centro de Investigacion en Artritis y Osteoporosis SC

    Mexicali, Estado de Baja California, 21200, Mexico

  • Centrul Medical Consultmed

    Iași, Iaşi, 700547, Romania

  • Centrum Badan Klinicznych PI-House sp. z o.o.

    Gdansk, Pomeranian Voivodeship, 80-546, Poland

  • Centrum Kliniczno-Badawcze

    Elblag, Warmian-Masurian Voivodeship, 82-300, Poland

  • Centrum Zdrowia Metabolicznego Pawel Bogdanski

    Poznan, Greater Poland Voivodeship, 60-589, Poland

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708, United States

  • Chellaram Diabetes Institute

    Pune, Maharashtra, 411021, India

  • Christian Medical College Vellore

    Vellore, Tamil Nadu, 632004, India

  • ClinDiab Kft.

    Budapest, Budapest, 1089, Hungary

  • Clinica Korall

    Satu Mare, Satu Mare County, 440055, Romania

  • Clinica Omega

    Mexico City, Mexico City, 06700, Mexico

  • Clinica de Investigacion en Reumatologia y Obesidad S. C.

    Guadalajara, Jalisco, 44650, Mexico

  • Clinical Neuroscience Solutions

    Orlando, Florida, 32801, United States

  • Clinique de médecine Urbaine du Quartier Latin

    Montreal, Quebec, H2L 4E9, Canada

  • Clinvest Research LLC

    Springfield, Missouri, 65807, United States

  • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

    Seville, Sevilla, 41003, Spain

  • Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval

    Ferrol, A Coruña [La Coruña], 15405, Spain

  • Cotton O'Neil Diabetes & Endocrinology

    Topeka, Kansas, 66606, United States

  • DRC Gyógyszervizsgáló Központ

    Balatonfüred, Veszprém megye, 8230, Hungary

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, Debrecen, 4032, Hungary

  • Debreceni Egyetem Klinikai Központ

    Debrecen, Debrecen, 4031, Hungary

  • Deenanath Mangeshkar Hospital & Research Centre

    Pune, Maharashtra, 411004, India

  • Diabdana

    Oradea, Bihor County, 410147, Romania

  • Diamed Obesity

    Galati, Galați County, 800291, Romania

  • Diseno y Planeacion en Investigacion Medica

    Guadalajara, Jalisco, 44130, Mexico

  • Dr. Steven V. Zizzo Medicine Professional Corporation

    Hamilton, Ontario, L8J 0B6, Canada

  • EME RED Hospitalaria

    Mérida, Yucatán, 97000, Mexico

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814, United States

  • Emeritus Research

    Botany, New South Wales, 2019, Australia

  • Emeritus Research

    Camberwell, Victoria, 3124, Australia

  • Endolife Speciality Hospitals

    Guntur, Andhra Pradesh, 522001, India

  • Eternal Heart Care Center and Research Institute

    Jaipur, Rajasthan, 302020, India

  • Fusion Clinical Research

    Adelaide, South Australia, 5000, Australia

  • FutureSearch Trials of Neurology

    Austin, Texas, 78731, United States

  • Gabinety TERPA

    Lublin, Lublin Voivodeship, 20-333, Poland

  • Gama Diamed

    Mangalia, Constanța County, 905500, Romania

  • Glasgow Royal Infirmary

    Glasgow, Scotland, G31 2ER, United Kingdom

  • Great Lakes Research Group, Inc.

    Bay City, Michigan, 48706, United States

  • Heartlands Hospital

    Birmingham, Birmingham, B9 5SS, United Kingdom

  • Hightech Medical Services SRL-Centrul pentru Studiul Metabolismului

    Bucharest, Bucharest, 011053, Romania

  • Hospital General Universitario de Valencia

    Valencia, Valenciana, Comunitat, 46014, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona [Barcelona], 08035, Spain

  • Hospital Universitario Dr. Jose Eleuterio Gonzalez

    Monterrey, Nuevo León, 66460, Mexico

  • Hospital Universitario Marqués de Valdecilla

    Santander, Cantabria, 39008, Spain

  • ILS Hospitals

    Kolkata, West Benga, 700064, India

  • INTERCOR

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-605, Poland

  • Indian Institute of Diabetes

    Thiruvananthapuram, Kerala, 695031, India

  • Instituto de Diabetes, Obesidad y Nutricion

    Cuernavaca, Morelos, 62250, Mexico

  • Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos

    Chihuahua City, Chihuahua, 31110, Mexico

  • Jothydev's Diabetes and Research Center

    Trivandrum, Kerala, 695032, India

  • Juno Research

    Houston, Texas, 77040, United States

  • Karnataka Institute of Medical Sciences

    Hubli, Karnataka, 580021, India

  • Kohler and Milstein Research S.A. de C.V.

    Mérida, Yucatán, 97070, Mexico

  • Layton Medical Centre

    Blackpool, Lancashire, FY3 7EN, United Kingdom

  • Leicester General Hospital

    Leicester, Leicestershire, LE5 4PW, United Kingdom

  • Lifepoint Multispeciality Hospital

    Pune, Maharashtra, 411057, India

  • Lillestol Research

    Fargo, North Dakota, 58104, United States

  • Logan Hospital

    Meadowbrook, Queensland, 4131, Australia

  • MICS Centrum Medyczne Warszawa

    Warsaw, Masovian Voivodeship, 00-874, Poland

  • MedVadis Research Corporation

    Waltham, Massachusetts, 02451, United States

  • Medical Investigations

    Little Rock, Arkansas, 72211, United States

  • Medifarma 98 Kft

    Nyíregyháza, Nyíregyháza, 4400, Hungary

  • NZOZ Salvia CM

    Katowice, Silesian Voivodeship, 40-772, Poland

  • Neuro-Pain Medical Center

    Fresno, California, 93710, United States

  • NeuroTrials Research Inc

    Atlanta, Georgia, 30328, United States

  • New Horizon Research Center

    Miami, Florida, 33165, United States

  • Nightingale Research

    Adelaide, South Aust, 5000, Australia

  • North Georgia Clinical Research

    Woodstock, Georgia, 30189, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • One Clinical Research

    Nedlands, Western Australia, 6009, Australia

  • Palm Research Center Tenaya

    Las Vegas, Nevada, 89128, United States

  • Panthera Biopartners - North London

    Enfield, London, City of, EN3 4GS, United Kingdom

  • Panthera Biopartners - Sheffield

    Sheffield, Sheffield, S2 5FX, United Kingdom

  • Policlinica Astra Sibiu

    Sibiu, Sibiu County, 550371, Romania

  • Ponce Medical School Foundation Inc.

    Ponce, 00716, Puerto Rico

  • Private Practice - Dr. Arechavaleta Granell Maria del Rosario

    Guadalajara, Jalisco, 44670, Mexico

  • Private Practice - Dr. Robert Witek

    Tarnów, Lesser Poland Voivodeship, 33-100, Poland

  • Progressive Medical Research

    Port Orange, Florida, 32127, United States

  • RM Pharma Specialists

    Mexico City, Mexico City, 03100, Mexico

  • Rainier Clinical Research Center

    Renton, Washington, 98057, United States

  • Regia Med Kft

    Székesfehérvár, Fejér, 8000, Hungary

  • Rochester Clinical Research, LLC

    Rochester, New York, 14609, United States

  • Rowden Surgery

    Chippenham, England, SN15 2SB, United Kingdom

  • SC Minimed SRL

    Bacau, Bacău, 600274, Romania

  • Specjalistyczna Praktyka Lekarska Diabetologia, Leczenie Cukrzycy i Otylosci

    Kielce, Świętokrzyskie Voivodeship, 25-355, Poland

  • St Clare Medical Centre

    Penzance, TR18 3DX, United Kingdom

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303, United States

  • Suncoast Research Group

    Miami, Florida, 33135, United States

  • Surat Institute of Digestive Sciences Hospitals

    Surat, Gujarat, 395002, India

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

    Szeged, Csongrád megye, 6725, Hungary

  • Teradan Clinical Trials, LLC

    Brandon, Florida, 33511, United States

  • The AIM Centre / Hunter Diabetes Centre

    Merewether, New South Wales, 2291, Australia

  • Trial Management Associates - Wilmington - Floral Parkway

    Wilmington, North Carolina, 28403, United States

  • Tribe Clinical Research - Spartanburg

    Spartanburg, South Carolina, 29301, United States

  • Tribe Clinical Research, LLC

    Greenville, South Carolina, 29607, United States

  • Unidad biomedica avanzada monterrey

    Monterrey, Nuevo León, 64460, Mexico

  • Unidad de Investigación Clínica y Atención Médica HEPA

    Guadalajara, Jalisco, 44670, Mexico

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

  • Uniwersytecki Szpital Kliniczny w Białymstoku

    Bialystok, Podlaskie Voivodeship, 15-276, Poland

  • Valley Research

    Fresno, California, 93720, United States

  • Vanderbilt Health One Hundred Oaks

    Nashville, Tennessee, 37204, United States

  • Wharton Medical Clinic

    Hamilton, Ontario, L8L 5G8, Canada

  • Wockhardt Hospital - Mumbai Central

    Mumbai, Maharashtra, 400011, India

  • Yale University School of Medicine

    New Haven, Connecticut, 06519, United States

  • Your Research Network

    Niagara Falls, Ontario, L2H 1H5, Canada

  • Óbudai Egészségügyi Centrum

    Budapest, Budapest, 1036, Hungary

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