Scientists watch how weight loss reshapes fat and body chemistry
NCT ID NCT07456124
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study followed 22 adults with obesity who went through a standard diet program, starting with a very-low-calorie diet and then a regular weight loss diet with counseling. Researchers measured weight loss, body fat distribution, glucose metabolism, and inflammation over 12 months. The goal was to understand how the body adapts to weight loss, not to test a new drug or treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this study could help doctors better understand how weight loss affects fat tissue and metabolism, potentially improving obesity treatment plans.
- What could go wrong
- This is a small observational study with only 22 participants, so results may not apply to everyone. It does not test a new treatment, only observes standard care.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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22 people
The number who actually took part.
- Started
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Aug 2014
- Finished
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Aug 2016
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients seeking treatment for obesity at Helsinki University Central Hospital and affiliated outpatient obesity clinics.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years * BMI ≥28 kg/m² * Seeking treatment for obesity at Helsinki University Central Hospital or affiliated units Exclusion Criteria: * Pregnancy or lactation * Current smoking * Anemia (Hb \<130 g/L in men; \<120 g/L in women) * Severe comorbid disease or condition judged by investigator to compromise safety * Contraindications to MRI (e.g., metal implants, claustrophobia)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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