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Scientists watch how weight loss reshapes fat and body chemistry

NCT ID NCT07456124

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study followed 22 adults with obesity who went through a standard diet program, starting with a very-low-calorie diet and then a regular weight loss diet with counseling. Researchers measured weight loss, body fat distribution, glucose metabolism, and inflammation over 12 months. The goal was to understand how the body adapts to weight loss, not to test a new drug or treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand how weight loss affects fat tissue and metabolism, potentially improving obesity treatment plans.
What could go wrong
This is a small observational study with only 22 participants, so results may not apply to everyone. It does not test a new treatment, only observes standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

22 people

The number who actually took part.

Started

Aug 2014

Finished

Aug 2016

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients seeking treatment for obesity at Helsinki University Central Hospital and affiliated outpatient obesity clinics.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * BMI ≥28 kg/m² * Seeking treatment for obesity at Helsinki University Central Hospital or affiliated units Exclusion Criteria: * Pregnancy or lactation * Current smoking * Anemia (Hb \<130 g/L in men; \<120 g/L in women) * Severe comorbid disease or condition judged by investigator to compromise safety * Contraindications to MRI (e.g., metal implants, claustrophobia)

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Conditions

The condition(s) this trial relates to.

Inflammation Obesity obesity disorder Overweight Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

More trials for these conditions

Other studies related to the condition(s) this trial covers.