OBESITY (DISORDER)

This study aims to see if giving people healthy prepared meals and education helps them eat better compared to just physical activity coaching. It involves 120 adults in Anson County who have or are at risk for chronic conditions like obesity, diabetes, or heart disease. Particip…

This study follows overweight adults aged 30-65 who previously tried a fasting-mimicking diet to see if they can keep off at least half the fat they lost. Participants will continue the diet every three months for one year. Researchers will also check if improvements in heart hea…

This study compares a new magnetic surgery that connects parts of the intestine to a common diabetes medication (semaglutide) for controlling obesity and type 2 diabetes. About 20 adults with a BMI of 30-40 and type 2 diabetes will be randomly assigned to one of the two treatment…

This study looks at how the body adapts to weight loss in teens aged 12-17 with obesity. Participants will either follow a lifestyle program alone for 6 months, then add the drug semaglutide, or start both together. The goal is to see if adding semaglutide helps the body burn ene…

This study tests whether 30 sessions of far infrared sauna bathing can improve blood pressure and blood sugar control in adults with obesity. Twenty participants with a BMI between 30 and 45 will undergo the sauna therapy. Researchers will measure changes in blood pressure, gluco…

This study tests a very low-calorie ketogenic diet (600-800 calories per day) in 14 adults with type 1 diabetes and obesity who use an automated insulin pump. The goal is to see if the diet can help them lose about 5% of their body weight in 4 weeks without causing dangerous drop…

This study aims to see how well a mix of traditional Chinese medicine and Western medicine works for people with obesity. Researchers will track at least 10,000 adults with a BMI of 28 or higher over 24 weeks, measuring weight loss and other health changes. The goal is to find be…

This study aims to find the best way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants lose more weight. The study involves 300 adults with a BMI of 25 or higher who own a compatible smartpho…

This study looks at whether a GLP-1 agonist (a type of drug used for diabetes and weight loss) can help restore normal hormone rhythms in obese teenage girls with Polycystic Ovary Syndrome (PCOS). Twenty girls aged 12–18 will take the drug for 16 weeks along with diet and exercis…

This study looks at how tirzepatide, a weight-loss medication, affects muscle strength, structure, and metabolism in women with obesity. Thirty premenopausal women will receive either tirzepatide or a placebo for 24 weeks. Researchers will measure body composition, muscle functio…

This study looks at how two weight-loss medications, tirzepatide and liraglutide, affect bone strength and body composition in adults with severe obesity (BMI 40 or higher). Researchers will track 72 participants for 6 months, measuring bone turnover markers and body changes. The…

This study looks at how obesity harms the heart and blood vessels, and whether weight loss surgery can reverse that damage. Researchers will follow 85 adults with obesity for a year after surgery, checking blood vessel function, fat tissue, and inflammation. The goal is to unders…

This study aims to understand why obesity increases the risk of a specific type of heart failure called HFpEF, where the heart becomes stiff. Researchers will follow 250 people with obesity for two years, using heart ultrasounds and blood tests to detect early signs of heart prob…

This study looks at whether a special diet that promotes a healthy mix of gut bacteria can improve weight loss and eating habits after bariatric surgery. About 60 adults who are having weight-loss surgery will be split into two groups: one gets standard nutrition advice, the othe…

This study will test if weight-loss surgery can improve thinking and memory in 42 adults with severe obesity. Participants will play a virtual reality game and take standard brain tests before surgery and again 3 and 6 months after. The goal is to see if losing weight helps the b…

This study looks at how adults on GLP-1 therapy (medications for obesity or type 2 diabetes) change their eating habits. Researchers want to understand what people actually eat, what challenges they face, and what kind of dietary support would help them stay healthy long-term. Th…

This study looks at what happens when people stop taking the weight-loss drug semaglutide. It compares two strategies: stopping all at once versus slowly reducing the dose. The goal is to see which approach helps maintain weight loss and heart health. About 98 adults who have alr…

This pilot study tests whether a single dose of a food additive (potassium sorbate) changes how much adults with obesity eat over 24 hours, compared to a placebo. The main goal is to see if the study methods work well, like recruiting participants and getting them to follow the d…

This study aims to find the most effective way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants track their progress and lose more weight. About 127 adults with overweight or obesity will us…

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This study looks at 52 obese adults having weight-loss surgery to see which method better predicts a difficult breathing tube insertion: a standard checklist (El Ganzouri Risk Index) or an ultrasound of the airway. Participants will be checked before surgery using both methods, a…

This study looks at how compounds from mangoes (gallotannins) and a probiotic called Lactiplantibacillus pentosus affect gut bacteria and inflammation in people with obesity. Researchers will use stool samples from 20 participants (lean and obese) to test different combinations i…

This study looks at why people with obesity often have low iron levels. Researchers will test if losing weight (which reduces inflammation) or breathing low-oxygen air at night (which signals the body to make more red blood cells) can improve how well the body absorbs iron from f…