OBESITY & OVERWEIGHT

This study tests two experimental drugs, AZD6234 and AZD9550, alone or together, in Chinese adults who are overweight or have obesity. The goal is to see if they are safe and help with weight loss. About 871 participants aged 18 to 55 with a BMI of 27 or higher will take part.

This study tests whether giving adults with obesity and food insecurity access to healthy groceries or vouchers, along with behavioral weight loss coaching, leads to greater weight loss than coaching alone. About 300 participants will be followed for a year. The goal is to see if…

This study tests whether offering personalized financial incentives can help adults with obesity stick to a weight-loss program. Participants will attend virtual group classes, log their food, and weigh themselves regularly. The goal is to see if tailored rewards improve self-mon…

This study looks at whether giving free summer day camp vouchers to low-income children (ages 5-11) who are overweight or obese can help them manage their weight. The camp provides physical activity, healthy meals, and regular sleep. Researchers will compare kids who get the vouc…

This study tests whether a special medical food can help adults on popular weight loss drugs (like Wegovy or Mounjaro) keep their muscle while losing weight. About 144 overweight or obese adults will take either the food or a placebo for 24 weeks. The goal is to see if the food h…

This study tests a 24-week church-based program for Black men aged 35-70 who are at risk for heart disease, diabetes, and obesity. Participants attend weekly sessions with exercise and health education, get one-on-one support, and use smart devices to track progress. The goal is …

This study tests a 26-week program designed to help people who have intentionally lost weight keep it off. Participants receive educational texts, complete weekly surveys, and weigh themselves at home. Some may also get health coaching. The goal is to see if this personalized app…

This study compares a new magnetic surgery that connects parts of the intestine to a common diabetes medication (semaglutide) for controlling obesity and type 2 diabetes. About 20 adults with a BMI of 30-40 and type 2 diabetes will be randomly assigned to one of the two treatment…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps people with prediabetes improve blood sugar control and stick to healthy habits better than traditional finger-prick testing. About 80 adults with prediabetes, who are either on diet and exerci…

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 people with atrial fibrillation will be random…

This study tests whether adding semaglutide (a drug used for diabetes and weight loss) to a standard topical cream can improve psoriasis and reduce inflammation. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will receive either semaglutide or a …

This study tests whether powerful weight loss drugs can lower blood pressure in young adults (ages 18-40) who are overweight or obese and have early-stage hypertension. Participants will either receive standard care (medication and lifestyle advice) or a weight loss drug. The goa…

This study is testing a weight-loss drug called Spartina® (Tirzepatide) in 175 adults with obesity or overweight. Participants will receive the drug and be monitored for weight loss and side effects. The goal is to see if the drug works and is safe in everyday use, not just in co…

This study looks at whether adding exercise to a structured weight loss program helps teens with obesity lower blood fats and improve blood vessel function. About 110 participants aged 10-20 will be followed for 6 months. The goal is to see if more physical activity leads to bett…

This study is testing whether taking a supplement containing a beneficial gut bacterium (Akkermansia muciniphila) and a plant compound (berberine) can improve how the body uses insulin in night-shift workers. Night-shift work often disrupts sleep and eating patterns, raising the …

This study aims to see if prescribing a specific number of daily steps based on a person's weight and body fat can help overweight or obese adults lose weight and improve heart health. Researchers will first develop a formula to predict weight loss from step counts, then test it …

This study tests whether adding enobosarm to the weight-loss drug semaglutide helps people aged 65 and older lose more weight while keeping their muscle strength and physical function. About 200 participants will receive either the combination or semaglutide alone. The goal is to…

This study tests a new medicine called HDM1005, given as a weekly injection, to help people with obesity or overweight lose weight. About 825 Chinese adults who do not have diabetes will receive either the drug or a placebo for 52 weeks, along with diet and exercise advice. The m…

This study tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve irregular periods in women with PCOS who are overweight or have obesity. About 198 women will receive either tirzepatide or a placebo for 72 weeks. The goal is to see if the drug h…

This study is testing whether a supplement called Xanthigen, made from seaweed and pomegranate seed oil, can help overweight adults lose weight. Researchers will give 180 participants either a low dose, high dose, or a placebo for 16 weeks. The main goal is to see if Xanthigen le…

This study tests whether empagliflozin, a drug used for diabetes, can help people with HIV who are overweight or obese lose weight and improve their metabolism. About 66 adults with HIV on a specific type of antiretroviral therapy will take either the drug or a placebo for 6 mont…

This study looks at whether connecting youth (ages 12-25) with community programs rooted in Native Hawaiian culture can improve their mental and physical health. Participants will take part in activities that strengthen their connection to the land and culture, and complete surve…

This small pilot study is testing whether eating bottarga (a type of fish roe) every day for 8 weeks can improve cholesterol, blood sugar, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 adults from Massachusetts will take part. The goal is to see if t…

This study tests a special bed scale called FIT that automatically tracks weight when a person gets in or out of bed. It aims to help 92 wheelchair users who are overweight or obese lose weight by giving them daily feedback, along with a diet and exercise program. Participants mu…

This study looks at whether a structured exercise program can help overweight and obese women aged 25-50 maintain muscle mass and physical function while taking the weight-loss drug tirzepatide. Participants will be split into two groups: one taking tirzepatide alone, and the oth…

This study tests a new surgical device (a clip) to treat type 2 diabetes and obesity in people with a BMI of 25-35. The surgery creates a second food pathway to help control blood sugar, similar to popular diabetes drugs. About 90 adults will be randomly assigned to different gro…

This study aims to see how well a mix of traditional Chinese medicine and Western medicine works for people with obesity. Researchers will track at least 10,000 adults with a BMI of 28 or higher over 24 weeks, measuring weight loss and other health changes. The goal is to find be…

This study explores whether analyzing the chemicals in your breath can help doctors identify metabolic syndrome and metabolically healthy obesity without blood draws or invasive tests. Researchers will collect breath samples from 300 adults and use machine learning to find unique…

This study tests whether a daily supplement made from artichoke by-products, combined with a calorie-controlled Mediterranean diet, can improve blood sugar control and reduce insulin resistance in 150 overweight or obese adults at risk for type 2 diabetes. Researchers will also u…

This study tests a 6-month lifestyle program designed to prevent obesity and eating disorders in transgender and gender-diverse adolescents aged 10-14. Participants attend monthly group sessions and receive weekly supportive messages, while a control group gets standard care. The…

This study tests a program designed to prevent childhood obesity in vulnerable families with children aged 6 months to 3 years. About 526 families with at least one parent who has overweight or obesity will take part. The program includes group sessions on healthy eating, physica…

This study looks at whether a 5-week exercise program (a mix of aerobic and strength training) can improve muscle health, body composition, and quality of life for people who have had bariatric surgery. About 84 adults aged 18 to 60 who had sleeve gastrectomy or gastric bypass wi…

This study aims to find the best way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants lose more weight. The study involves 300 adults with a BMI of 25 or higher who own a compatible smartpho…

This study looks at whether wearing a continuous glucose monitor (CGM) that shows real-time blood sugar levels helps people with prediabetes and obesity make healthier choices, compared to a hidden CGM. About 34 adults will try both types of monitoring to see which leads to bette…

This early-phase study tests whether a cold water extract from saffron flower petals (Crocus sativus tepals) can improve blood sugar and metabolism after a meal. Twenty adults with obesity or prediabetes will drink either the extract or plain water before eating white bread, then…

This study looks at whether special breathing exercises (inspiratory muscle training) can improve lung function and reduce inflammation in people with obesity. About 40 adults aged 30-60 with a BMI of 30 or higher will be enrolled. Researchers will measure breathing capacity, mus…

This study looks at whether eating pistachios every day for 12 weeks can help people on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their overall diet quality. Researchers will track changes in hunger, fatigue, mood, and body com…

This study looks at whether adding peanuts to daily meals helps people on GLP-1 medications (like semaglutide or tirzepatide) feel fuller, have more energy, and improve their diet quality. Researchers will follow 64 adults who have been on these meds for at least 6 months. Over 1…

This study tests whether a safe, home-use brain stimulation technique called tDCS can improve memory and thinking in breast cancer survivors who struggle with 'chemo brain.' Forty women who finished cancer treatment at least 3 months ago will receive either real or fake (placebo)…

This study looks at whether a new ultrasound technology called REMS can safely measure bone density in children aged 5 to 18 who have conditions that weaken bones, like osteoporosis or growth hormone deficiency. Unlike the current standard (DXA), REMS uses no radiation. The goal …

This study looks at whether a special type of high-intensity interval training can help adults with overweight or obesity improve their vitamin D levels during winter. Vitamin D deficiency is common in people with higher body weight, possibly because it gets trapped in fat tissue…

This study is creating new questionnaires to better understand how overweight and obesity affect people's lives, including their health, daily activities, and finances. Researchers will ask 500 adults with a BMI over 25 and healthcare professionals to complete surveys. The goal i…

This study aims to find the most effective way to give weekly feedback to people trying to lose weight. Researchers will test different types of messages to see which helps participants track their progress and lose more weight. About 127 adults with overweight or obesity will us…

This study follows 52 teens (ages 12–17) getting braces to see if having a higher body weight leads to more gum inflammation, white spots on teeth, or changes in mouth bacteria. Participants are split into two groups based on their BMI (normal vs. overweight/obese). Researchers w…

This study looks at how taking a new medicine (CX11) with or without food changes the way the body absorbs it. It involves 32 healthy adults who will take the drug twice under different conditions. The results will help doctors decide the best way to take this drug in future stud…

This study is collecting and analyzing genetic, metabolic, and microbiome data from over 6,000 people with and without metabolic syndrome. The goal is to identify biological markers that predict disease progression and help create personalized prevention and treatment plans. Part…

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This study looks at how the stomach and intestines digest food after bariatric surgery. Researchers will collect digestive samples and use a special capsule that measures things like acidity and movement inside the gut. The goal is to better understand digestion in people who hav…

This study is creating a simple index to measure how well the body uses insulin and overall heart and metabolic health in children and teens with obesity. Researchers will use data from wearable devices like fitness trackers and glucose monitors, along with lab tests, to understa…

This study looks at how semaglutide, a diabetes and weight-loss drug, affects fat around the kidneys, heart, and liver in people with type 2 diabetes and chronic kidney disease. Researchers want to understand if changes in fat tissue can slow kidney disease. About 52 adults from …

This study looks at how two natural hormones, amylin and pancreatic polypeptide, affect hunger and food intake in healthy men. Over four separate days, 18 participants will receive different combinations of these hormones or a placebo. Researchers will measure how much they eat a…

This study looks at whether people who became obese as children have different fat, muscle, and metabolism than those who became obese as adults. About 150 adults aged 25-40 with obesity will have biopsies, scans, and exercise tests. They will also follow a weight loss program to…

This study looks at how the drug GZR18, being tested for obesity, behaves in people with different levels of kidney function. Researchers will give a single dose to 32 adults with normal kidneys or mild to severe kidney problems. The goal is to see if kidney function changes drug…

This study looks at how weight loss (using tirzepatide) and a biologic drug (ixekizumab) change the skin, joint, and fat tissues in people with psoriatic arthritis who are overweight or obese. About 45 adults will take one or both treatments for 12 weeks, with tissue and blood sa…

This study looks at whether a 40-minute sauna session before a meal can lower blood sugar spikes in overweight adults. Fifteen participants aged 30-55 with a BMI of 27 or higher will have their glucose monitored continuously. They will visit the lab twice—once for a sauna and onc…

This study looks at how GLP-1 weight loss drugs (like semaglutide) change taste, eating habits, and behavior in adults with obesity. Researchers will review medical records and surveys from 150 people aged 18-60 in Italy. The goal is to understand why these drugs help people eat …

This study looks at 52 obese adults having weight-loss surgery to see which method better predicts a difficult breathing tube insertion: a standard checklist (El Ganzouri Risk Index) or an ultrasound of the airway. Participants will be checked before surgery using both methods, a…

This study looks at 500 people who are offered medications for obesity or overweight. Researchers want to understand what makes someone accept or refuse the prescription, including their medical history, lifestyle, and social factors. For those who start the drug, the study will …

This study looks at how body weight and bariatric surgery change natural chemicals in scalp hair. Researchers will also measure hair thinning and muscle loss in the first 6 months after surgery. The study includes 60 adults: some with severe obesity scheduled for surgery, and som…

This study aims to find out how common metabolic dysfunction-associated fatty liver disease (MAFLD) is among adults in rural Bangladesh. Researchers will check 1,000 participants using physical exams, blood tests, and ultrasound scans. The goal is to understand how diet, weight, …

This study aims to find out why some people lose more weight than others after obesity treatments like surgery or medication. Researchers will look at eating behaviors, thinking patterns, and biological markers in 100 adults with obesity. The goal is to better personalize care an…

This study looks at how ketone bodies—chemicals your liver makes when you fast or exercise—affect how your body uses energy and responds to insulin. Ten overweight adults aged 55–70 will each try four different treatments (including a ketone drink and a placebo) on separate days.…

This study looks at how the tongue changes in children and teens with obesity after a 30-week weight loss program. Researchers will use ultrasound to measure tongue fat, shape, and stiffness, and see how these relate to sleep apnea. About 100 participants aged 6 to 18 will be sca…

This study tests whether taking a daily sirtuin activator supplement for six months can improve metabolism and reduce signs of cell aging in women aged 40 to 65 who are overweight or obese. Researchers will compare the supplement to a placebo and measure changes in blood fats, bl…

This study looks at how exercise affects blood components and physical fitness in overweight or obese adults. Researchers will measure things like body fat, strength, and heart health, as well as tiny particles in the blood called extracellular vesicles. The goal is to learn more…

This study looks at different ways to track eating and weight during a 24-week online weight loss program. About 275 adults with overweight or obesity will try a new tracking method every two weeks, like recording all foods, only slip-ups, or using a smartwatch. The goal is to se…

This study aims to find the best combination of support strategies to help adults with higher body weight eat well and stay active. Researchers will test five different group programs delivered online, each with unique features like mindful eating, body image support, or enjoyabl…