OBESITY & OVERWEIGHT

This study will give 150 children with high blood pressure, high cholesterol, or obesity a prepaid card to buy fruits and vegetables, plus virtual nutrition classes. The goal is to see if this program improves their eating habits and heart health over 6 to 12 months. Participants…

This study tests whether daily lutein from microalgae can slow age-related mental decline and reduce inflammation in 300 postmenopausal women with belly obesity. Participants will take either 6 mg, 14 mg of lutein, or a placebo for 6 months. Researchers will measure changes in me…

This study tests a custom mouthpiece called Fuzzle, worn during the day, to help adults with obesity lose weight. About 78 people will either get the device plus lifestyle advice or just advice alone for 16 weeks. The goal is to see if the device leads to more weight loss than co…

This study tests personalized diet and exercise plans to help adults aged 50-75 with obesity lose weight while keeping muscle. Participants will follow different protein and exercise routines over 52 weeks. The goal is to find the best approach for healthy weight loss in older ad…

This study tests whether adding regular exercise to a weight-loss medication (tirzepatide) helps people lose more weight and improve health markers like blood sugar and cholesterol. Researchers will enroll 24 adults aged 30-65 who are overweight or have obesity. Participants will…

This study tests whether providing healthy foods and cooking lessons can help adults with high blood pressure and obesity lower their blood pressure and lose weight. About 150 participants will either receive the food program or standard care for 24 weeks. The goal is to see if t…

This study tests whether a home-based high-intensity interval training (HIIT) programme can help people who have reversed their type 2 diabetes keep it from returning. Twenty adults who completed the NHS Path to Remission programme will either do HIIT three times a week or contin…

This study tests a 2-month program to help 60 adults with overweight or obesity eat fewer ultra-processed foods. Participants will be randomly assigned to standard diet advice, a program that uses activism against the food industry to create motivation, or both. The goal is to se…

This study tests an experimental oral drug called ERX1000 for weight loss in 80 adults with obesity (BMI 30-50). Participants will take the drug or a placebo daily for 24 weeks to see if it safely reduces body weight. The trial is for people aged 18-60 who have had a stable weigh…

This study will test if combining GLP-1 medications (like semaglutide and tirzepatide) with Noom's digital health program helps people with obesity lose weight and improve health markers like blood sugar and cholesterol. About 2,310 adults will be followed for 24 months. The goal…

This study follows 3000 people with severe or complicated obesity who are taking semaglutide (Wegovy) in France. Researchers will track weight changes, who stays on the drug, and what factors predict success. The goal is to understand how this medication works outside of controll…

This study tests a program for women with severe obesity (BMI 40+) and early-stage endometrial cancer. The program includes weight loss medication, a hormone-releasing IUD, diet, and exercise to help them lose weight and improve health before surgery. The goal is to see if this a…

This study looks at whether playing active video games can help children and young adults (ages 5-21) with obesity and type 2 diabetes lose weight and lower their blood sugar (HbA1c). Participants will play active video games at home, and researchers will track changes in weight,…

This study looks at whether adding a 6-month program of exercise and nutrition counseling to standard weight-loss medication helps adults with obesity preserve muscle mass and strength. About 120 people aged 18-70 will be randomly assigned to get medication alone or medication pl…

This study tests a 10-week behavioral program to help people maintain weight loss after stopping GLP-1 or other anti-obesity medications. About 64 adults who lost at least 15% of their body weight on these drugs will be randomly assigned to extra support like tailored meals, gym …

This study looks at whether adding whole-body electrical muscle stimulation to a low-calorie diet helps obese adults lose weight and improve their metabolism. Forty people will be split into two groups: one only on a diet, the other on a diet plus muscle stimulation for 8 weeks. …

This study tests whether a 12-week program of exercise and personalized diet advice can help adults aged 40-55 prevent muscle loss while taking GLP-1 medications like semaglutide for weight loss. About 20 participants will be enrolled. The goal is to preserve muscle and bone heal…

This study tests a smart program for people with both knee osteoarthritis and obesity. The program uses AI-guided community exercise and continuous glucose monitoring to help control blood sugar, reduce knee pain, and improve daily function. Researchers will track 312 adults over…

This study looks at whether using a mobile wellness app together with a wearable fitness tracker helps people with obesity lose more weight than using the app alone. About 300 adults with a BMI of 25 or higher will be split into three groups: app plus tracker, app only, or standa…

This study tests a supplement called Redefine in 80 overweight adults who are already taking a weight-loss drug (semaglutide) and following a low-calorie diet. The goal is to see if Redefine is safe and helps preserve muscle mass, which often gets lost during rapid weight loss. P…

This early-stage study tests a new drug called SGB-7342 in 45 adults who are overweight or have obesity. The main goal is to see if a single injection under the skin is safe and tolerable. Researchers will also measure how the drug moves in the body and any weight changes. This i…

This study looks at whether tirzepatide, a drug used for weight loss, can help overweight or obese people with a type of irregular heartbeat called atrial fibrillation (AFib). About 200 adults will receive either tirzepatide injections plus standard care, or standard care alone, …

This study tests whether two types of fish oil, EPA and DHA, can improve how the body handles blood sugar and cholesterol in people at high risk for type 2 diabetes. Over 12 weeks, 84 adults with obesity will take daily capsules of EPA, DHA, or a placebo (corn oil). Researchers w…

This study reviews medical records of 500 adults with obesity or overweight who took a combination of sibutramine and topiramate for at least three months. The goal is to see how much weight they lost and whether the treatment was safe and tolerable. This affordable option may he…

This study tests whether taking semaglutide (Wegovy) before a standard heart procedure for atrial fibrillation (AF) can help prevent the abnormal heart rhythm from coming back. About 200 adults with AF and overweight or obesity will receive either standard care or semaglutide plu…

This study looks at whether a 4-month Zumba program can improve heart health, hormones, and body measurements in overweight women. About 73 women, both before and after menopause, will be randomly assigned to either take Zumba classes or continue their usual routine. The goal is …

This study looks at whether adding the Nutu™ digital health platform to standard obesity treatment helps people lose more weight. About 300 adults in a primary care program will be offered the app, and researchers will track weight changes and how often people use it. The goal is…

This study tests tirzepatide (Munjaro), a drug already used for weight loss and diabetes, in 30 obese adults with congenital heart disease. Over 6 months, researchers will measure changes in exercise ability, heart function, and cholesterol. The goal is to see if this drug can im…

This study will test if a 1-3 minute facial scan using artificial intelligence can accurately measure health indicators like heart rate, blood pressure, blood sugar, and even stress levels. Researchers will compare the scan results with standard medical tests in 1000 adults livin…

This study compares two blood-thinning injections, tinzaparin and enoxaparin, to see which better prevents dangerous blood clots after weight loss surgery. About 180 adults having laparoscopic bariatric surgery will be randomly assigned to receive one of the two injections daily …

This study tests a program called Healthy Eating for My Infant (HEMI) for babies from low-income families. The program helps moms with mental health and feeding challenges to lower obesity risk. About 60 families will take part, with some getting the program and others not. Resea…

This study looks at whether providing free center-based childcare during the summer can prevent unhealthy weight gain in preschoolers from low-income families. About 300 children enrolled in needs-based pre-K programs will take part. Researchers will measure body fat and BMI to s…

This pilot study tests whether providing Mediterranean diet groceries along with virtual nutrition classes helps adults at risk for type 2 diabetes improve their eating habits and lose weight. Forty overweight adults from the US South will be randomly assigned to receive either w…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are overdue for screening will try the program, which offers options like self-collection for HPV testing. The goal is to see if the program i…

This study tests if an experimental drug called BIO101 can help prevent muscle strength loss in people taking the weight-loss medication semaglutide. About 164 obese or overweight adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide an…

This study looks at whether adding a smartphone app to group therapy helps teens aged 12-17 who have both depression and overweight. The app is designed to help them practice therapy skills in daily life. Researchers will compare teens who get therapy plus the app to those who ge…

This early study tests a small implant placed under the skin that releases semaglutide (the drug in Wegovy) over 4 weeks. It compares the implant to weekly injections in 20 healthy overweight or obese adults. The goal is to see if the implant is safe and how it affects drug level…

This study tests a new approach called 'exercise snacking' for adults aged 65 and older who are overweight. Instead of one long workout, participants do several short, 2-5 minute activity bursts throughout the day. The goal is to see if this easier routine helps improve strength,…

This study looks at how a special type of exercise called hybrid high-intensity interval training affects muscle cells in 30 overweight or obese adults over the long term. Researchers will measure changes in mitochondria (the cell's power plants), muscle fibers, and overall fitne…

This study looks at how posture habits and body awareness are linked to physical function in women across different weight categories (normal, overweight, and obese). Researchers will group 80 women by their body mass index and use questionnaires and physical tests to measure the…

This study looks at how much energy obese teenagers burn after eating, and whether losing weight changes that. Researchers will compare 30 teens with obesity to normal-weight teens. The goal is to better understand how the body uses calories from food, which could help improve we…

This study will check if common weight loss medications (semaglutide or tirzepatide) combined with lifestyle coaching can reduce a person's biological age. Researchers will measure aging using a special blood test called LinAge2. The study includes 440 adults aged 40-89 who are o…

This study is testing a smartphone app called NutriTrack that uses artificial intelligence to help people with obesity track what they eat and their eating behaviors. About 20 to 50 adults will use the app for 4 weeks alongside their regular clinic visits. The goal is to see if t…

This online study with 2,800 Hong Kong adults tests whether putting warning labels on sugary drinks (like sodas) makes people less likely to buy them. Participants will choose a drink in a simulated shopping task. The goal is to see if these labels can help reduce sugar intake an…

This study will follow 150 mothers and their babies for 6 months to see if a mother's weight and diet affect her breastmilk and her baby's growth. Researchers will measure the mother's body fat, diet, and health markers, and analyze the breastmilk's nutrients and immune factors. …

This study will test two types of food package labels among 1,000 Indonesian adults to see which one better helps people spot unhealthy products and avoid buying them. Participants will compare nutrient warning labels with the Nutri-Level label. The goal is to find the most effec…

This study will follow 120 adults who are overweight, inactive, and at risk for health problems like metabolic syndrome. Participants will take part in programs focused on exercise, healthy eating (like the Mediterranean diet), and stress management. Researchers will track change…

This study aims to find out how common fatty liver disease is in adults who are overweight or have other metabolic risks like high blood pressure or diabetes. Up to 10,000 participants will fill out health questionnaires, have body measurements taken, and get blood tests and a li…

This pilot study will compare two diets—one high in ultra-processed foods and a typical American diet—in 6 adults with overweight or obesity. The goal is not to treat or cure, but to see if the study approach works and to gather data for planning larger future trials. Participant…

This study looks at how beta-cells (the cells that make insulin) respond to growth hormone in people with prediabetes. Researchers will compare two groups: those with impaired fasting glucose and those with impaired glucose tolerance. The goal is to better understand what leads t…

This early-stage study tests a new drug called DWRX5003 in 72 healthy adults to see if it is safe and how the body processes it compared to similar drugs. Participants must be between 19 and 65 years old with a healthy weight. The study does not aim to treat any disease, but to g…

This study looks at whether certain autoantibodies (proteins that attack the body's own cells) are present in people with obesity and if they are linked to how severe the obesity is. Researchers will also check if these antibodies are connected to obesity-related health problems …