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Can a stearic Acid-Rich diet improve blood vessel health?

NCT ID NCT07831603

NEW Prevention Sponsor: Florida State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers are testing whether a diet high in stearic acid, a type of saturated fat found in cocoa butter, improves blood vessel function compared with a diet high in oleic acid, the main fat in olive and canola oils. The trial enrolls 40 overweight or obese adults aged 40 to 70 with no major chronic diseases. Participants follow controlled diets for 14 days and then eat high-fat test meals while researchers measure blood vessel dilation and take blood samples over several hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
stearic acid-rich diet
What this could lead to
If stearic acid helps blood vessels work better, it could inform dietary advice for overweight or obese middle-aged adults at risk of heart disease.
What could go wrong
This is a small, short-term study of 40 people. The results may not apply to other groups, and diet studies often show modest or inconsistent effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ages 40-70 years * BMI 25.0-40.0 kg/m2 * Seated blood pressure \<130/80 mmHg * Willing and able to attend laboratory visits Exclusion Criteria: * Current diagnosis or history of diabetes, renal disease, liver disease, gallbladder disease, cholecystectomy, pancreatic disease, cancer, overt cardiovascular disease, or a major cardiovascular event (e.g., heart attack or stroke) * Current or recent use of weight loss medications * Significant change in bodyweight of ≥ 5% within the past 6 months * Current or recent use of glucose- or lipid-lowering drugs * Fasting LDL cholesterol ≥ 190 mg/dL or fasting plasma total cholesterol \> 7.8 mmol/L (302 mg/dL), or fasting plasma TAG \> 3 mmol/L (267 mg/dL) * Current or recent use of tobacco, nicotine, or illicit drugs * History of bariatric surgery * Hysterectomy or ovarian removal (females) * Pregnant or lactating * Athlete * Unwilling or unable to provide consent * Unwilling or unable to consume study diet

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy middle-aged subjects Obesity / overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Florida State University

    Tallahassee, Florida, 32306, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.