OBESITY & OVERWEIGHT

This study tests whether a structured high-protein diet with meal replacements helps adults with overweight or obesity lose more weight than a standard low-calorie diet. Sixty participants will follow a calorie-restricted plan and attend visits for body measurements and blood tes…

This study tests whether behavioral therapy, a combination medication (naltrexone/bupropion), or both can help people who experience loss-of-control eating after bariatric surgery. About 160 adults who had gastric bypass or sleeve gastrectomy about six months ago will participate…

This study tests whether taking a daily supplement called Urolithin A (500 mg) for 6 months helps adults with obesity lose weight while keeping their muscle mass strong. About 100 adults aged 30-60 with a BMI over 30 will follow a structured diet and sleep program, with half gett…

This study tests an investigational injection called GZR18 to help adults with obesity or overweight lose weight. About 630 participants in China will receive either the drug or a placebo, along with diet and exercise guidance. The main goal is to see how much weight they lose ov…

This study tests a supplement called cornfit™, made from corn silk, to see if it helps reduce body fat and manage weight. About 100 adults with a BMI between 25 and 32 will take either the supplement or a placebo for 12 weeks. Researchers will measure changes in body fat using a …

This study looks at whether a new digital weight-management program can help people with obesity lose weight and improve their quality of life. About 580 adults referred to NHS weight-loss services will use the program for 12 months. Researchers will measure weight change, cost-e…

This study will offer group medical appointments for weight loss to 3,600 adults with obesity (BMI 30 or higher) at Cleveland Clinic primary care offices. The goal is to see if these shared visits help people lose weight and improve heart health. Participants will attend group se…

This study tests whether the medication lisdexamfetamine can help people who have loss-of-control eating after bariatric surgery and did not improve with earlier treatments. About 60 adults who had gastric bypass or sleeve gastrectomy will receive either the medication or a place…

This study tests whether group food and nutrition education, based on Brazil's official dietary guidelines, can help adults with overweight or obesity eat better and lose weight. About 60 participants will attend four monthly group sessions or receive individual counseling. Resea…

This study tests whether a combination medication (naltrexone/bupropion) can help people who had weight-loss surgery avoid relapsing into loss-of-control eating and regain weight. About 100 adults who responded well to an earlier treatment will receive either the medication or a …

This study looks at 14 adults who had a second weight-loss surgery because they didn't lose enough weight or regained weight after their first surgery. Researchers will measure weight, body fat, muscle, and blood tests before surgery and one year later. The goal is to learn how w…

This study tests whether personalized nutrition coaching, delivered online, can help overweight or obese nurses in an Indonesian hospital lose weight, eat healthier, and become more active. About 44 nurses will receive individual guidance for 8 weeks. The goal is to see if this a…

This study tests a program to help preschool children ages 3 to 6 in Suzhou, China, maintain a healthy weight. About 1,486 children will take part. The program includes healthy eating, physical activity, and education for families and teachers. Researchers will measure changes in…

This study looks at whether 8 weeks of resistance training (like lifting weights) with blood flow restriction can increase muscle strength and improve health markers in adults with obesity. About 30 people aged 18-40 with a BMI between 30 and 40 will take part. Researchers will m…

This study compares two types of exercise training to see which one better improves heart health and physical fitness in young adults with obesity. Forty participants will follow a 12-week program, and researchers will measure changes in weight, body fat, blood pressure, choleste…

This study tests whether a carefully controlled low-fat diet can increase reproductive hormones in women with obesity who have infertility. Researchers will measure hormone levels in urine before and after the diet. The goal is to see if diet alone can improve fertility without m…

This study looks at what drives children and teenagers to be physically active. Researchers measured fitness, motor skills, thinking abilities, and body composition in 325 third-graders. The goal is to understand how to encourage lifelong physical activity and healthy development…

This study looks at how GLP-1 medications (like Ozempic) affect what and how people eat. Researchers will use a special device to measure every sip of sugary and fatty drinks taken by 140 adults—some on the drug, some not. The goal is to understand exactly how these drugs reduce …

This study uses advanced heart MRI scans to better understand early-stage heart failure in 3000 people with diabetes, high blood pressure, or obesity. Participants will get detailed imaging and check-ups, then be followed over time to see who develops serious heart problems. The …

This study was designed to see if adding the amino acid isoleucine to a healthy, low-isoleucine diet would change how the body responds to insulin in people with obesity and prediabetes. It planned to enroll adults with a BMI of 30 or higher who also had metabolic syndrome. Howev…

This study follows 500 adults with obesity who are trying to lose weight. Researchers collect data on their health, habits, and blood tests to find out what helps or hinders weight loss. The goal is to create personalized weight loss plans based on each person's unique profile.

This study looks at 49 adults who had bariatric surgery at least 5 years ago and either didn't lose enough weight or regained weight after initial success. Researchers measure body changes, eating disorder symptoms, emotional eating, and diet to understand what drives weight rega…

This study follows 50 obese patients (BMI over 32) aged 16-60 who are having weight-loss surgery. Researchers use MRI scans and blood tests before surgery and at 1, 3, and 6 months after to measure fat in the pancreas and check how well the pancreas is working. The goal is to see…

This study compares two ways of connecting the intestine during a type of weight-loss surgery called SADI-S. About 82 adults having this surgery will be randomly assigned to get either a hand-sewn or stapled connection. The goal is to see which method leads to fewer early problem…

This study re-examines 317 adults with type 2 diabetes who were first checked between 2019 and 2023. Researchers use advanced scans and blood tests to see how many have fatty liver disease (MASLD) and whether it has gotten better or worse over time. The goal is to learn what fact…

This study follows 20 adults who had sleeve gastrectomy surgery about 8 years ago to see how their weight, body composition, and health markers have changed. Researchers compare current measurements to data from before surgery and 6 months after. The goal is to understand how wel…