Can a Gut-Derived supplement protect muscle while you shed pounds?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 30-60 years (inclusive) at screening * BMI \> 30 kg/m² at screening * Visceral fat level ≥ 12 by segmental bioimpedance (InBody) at screening * Able and willing to follow the standardized lifestyle program (individualized energy restriction with higher protein, reduced carbohydrates, time-restricted eating 11:13) and sleep-hygiene guidance for 24 weeks * Willing to attend baseline and \~3-weekly follow-ups; undergo blood draws, bioimpedance, MaxPulse testing, and muscle strength/endurance tests; and complete questionnaires (WEL, PSQI, GPAQ) * Medication stability: chronic medications (e.g., treated hypertension, antidepressants) stable for ≥3 months before baseline; only clinically necessary changes allowed during the study * Permitted conditions/therapies (if stable): common allergies/atopic eczema; food intolerances; contraception and menopausal hormone therapy * Women of childbearing potential: negative pregnancy test at baseline; agreement to use highly effective contraception during the study and for 4 weeks after last dose; not breastfeeding * Able to provide written informed consent Exclusion Criteria: * Known thyroid disease (untreated/unstable hypothyroidism or hyperthyroidism) * Type 2 diabetes mellitus (diagnosed or on glucose-lowering therapy) * Autoimmune disease, including psoriasis * Inflammatory bowel disease or other chronic inflammatory GI disorders (e.g., Crohn's disease, celiac disease) * Dyslipidemia treated with statins * Pregnancy, lactation, or planned pregnancy during the study period * Active malignant disease * Cognitive impairment or neurodegenerative disease that may affect consent or adherence * Severe psychiatric disorder that would preclude participation (e.g., severe major depression) or unstable depression/medication changes within the past 3 months * Uncontrolled comorbidity or decompensated chronic disease (e.g., uncontrolled hypertension; systolic ≥175 mmHg at screening) * Severe or limiting musculoskeletal condition preventing participation in assessments or the lifestyle program * Use of non-study dietary supplements (vitamins, herbal/nutraceutical products) that the participant is unwilling or unable to discontinue from baseline through end of study * Known allergy/intolerance to Urolithin A or capsule excipients * Any condition that, in the investigator's judgment, makes participation unsafe or could compromise data integrity