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The diet paradox: could eating more actually help you keep weight off?

NCT ID NCT07739095

Knowledge-focused Sponsor: University of Ottawa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This study explores whether increasing calorie intake after weight loss can restore normal appetite control. Adults with obesity will follow a 20-week diet and exercise plan, then some will have their calories adjusted upward. The goal is to see if this reduces hunger and helps with weight maintenance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A behavioral intervention combining daily walking with a 20-week calorie-restricted diet, followed by an individually tailored increase in calories after weight loss.
What this could lead to
If supported, this could change how dieting is approached, potentially making weight maintenance easier by restoring normal appetite control.
What could go wrong
This is a small, early-stage study with only 40 participants, so results may not apply broadly. The approach may not work for everyone, and weight regain remains a risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Sep 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. 18-55 years of age; 2. non-smoking; 3. obese class I-II (30 kg/m2 ≤ BMI \< 40 kg/m2); 4. weight stable (± 2 kg during the 6 months prior to enrollment); 5. Sedentary (\<2 times/week of 30 min of continuous exercise) In addition, Females will be included if: 1\) premenopausal (2 menses in the 3 months preceding testing, no increase in cycle irregularity in the 12 months preceding testing). Exclusion Criteria: 1. have a current diagnosis of an axis 1 psychiatric disorder (i.e. mood, anxiety and eating disorders); 2. currently use antidepressants, thyroid medication, or any medication that could affect appetite; 3. have a history of cardiac problems or symptoms suggestive of any cardiac condition; 4. have a current diagnosis or history of diabetes, confirmed by a measure of HbA1c during the screening visit; 5. have alcohol intake that exceeds recommendations or alcoholism, or current addictions to opiates, cocaine or stimulants; 6. currently taking monoamine oxidase inhibitors, pressor agents, warfarin, anticonvulsants, phenylbutazone, or tricyclic antidepressants; 7. have uncontrolled thyroid disease; 8. have any osteoarticular condition, or other reasons that would prevent them from achieving the proposed walking targets. In addition, Females will be excluded if they: 1. are pregnant or planning to become pregnant over the course of the study; 2. are peri- or post-menopausal or have had surgically induced menopause.

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Conditions

The condition(s) this trial relates to.

Motor Activity Obesity obesity disorder Overweight Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity & overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Ottawa

    Ottawa, Ontario, K1S 5S9, Canada

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