Night-Shift workers test gut bug and herb combo to beat diabetes risk
NCT ID NCT07440147
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking a combination of Akkermansia muciniphila (a beneficial gut bacterium) and berberine (a plant compound) can improve insulin sensitivity in night-shift workers. 200 participants from healthcare and industry in Austria and Denmark will receive either the supplements or a placebo for 12 weeks, then switch after a break. The main goal is to see if this approach lowers insulin resistance, a key risk factor for type 2 diabetes.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Akkermansia muciniphila (a gut bacterium) and berberine (a plant compound) taken as dietary supplements
- What this could lead to
- If it works, this could point toward a simple supplement combination to help night-shift workers improve insulin sensitivity and reduce their risk of type 2 diabetes.
- What could go wrong
- This is an early-stage trial with no phase designation, and the supplements may not improve insulin sensitivity more than placebo. Results may not apply to non-shift workers or other populations.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2026
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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21 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Health care or industrial shift worker * Employed or self-employed working ≥ 24 h/week * Current night shift work (night shift defined as a work schedule that includes at least 3 hours of work between 00:00 and 5:00) with at least 2 consecutive nights/month * Night shift work duration \> 3 years * 4 or more night shifts/month Exclusion Criteria: * BMI of 40 kg/m² or higher * Pregnancy or planned pregnancy within 6 months of enrolment or breastfeeding women * Bariatric surgery * Surgery in the 3 months prior to the study or planned surgery in the next 6 months that, in the opinion of the investigators, could potentially affect the outcome of the study * Diagnosed diabetes type 1 or type 2 * Uncontrolled thyroid disease (confirmed by clinically significant abnormal TSH/T4 levels without stable medication for more than 3 months) * Chronic diseases (renal failure, active hepatitis, liver cirrhosis, myocardial infarction within the last 2 years, stroke, chronic obstructive pulmonary disease or cancer) * Immunodeficiency syndrome, active autoimmune or autoinflammatory disease (e.g. multiple sclerosis, lupus, rheumatoid arthritis), inflammatory bowel disease (e.g. IBS or ulcerative colitis) and acute episodes of atopic diseases (atopic dermatitis, asthma, type 1 allergies such as hay fever). Grave's disease, Hashimoto thyroiditis, Celiac disease, sarcoidosis, Lichen planus, are allowed, if well treated and stable * Regular intake of anticoagulants * Known allergy to any inactive or active ingredients in the study products * Participation in other clinical intervention trials during the study * Current or planned participation in a weight loss program (including intermittent fasting), extreme diet, or vigorous exercise (e.g., running, fast cycling, swimming laps, or playing intense sports that quickly raise your heart rate)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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FH JOANNEUM University of Applied Sciences
RECRUITINGGraz, Styria, 8020, Austria
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