Weight loss drugs may free young adults from blood pressure meds

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Eligibility criteria for randomisation Inclusion Criteria: * Aged 18 to 40 years (inclusive) * Body mass index (BMI) ≥27 kg/m2 * Clinical diagnosis of primary (essential) hypertension as per NICE guidance * Unattended brachial SBP ≥135 and/or DBP ≥85 mmHg and \<160/100 mmHg * Maximum of one antihypertensive medication Exclusion Criteria: • Anything in medical notes suggesting unsuitable in the opinion of the investigator Eligibility criteria for participation in weight loss arm Inclusion criteria: * Written informed consent * Aged 18 to 40 years (inclusive) * Body mass index ≥27 kg/m2 * Clinical diagnosis of primary (essential) hypertension as per NICE guidance * Unattended brachial SBP ≥135 and/or DBP ≥85 mmHg and \<160/100 mmHg * Maximum of one antihypertensive medication Exclusion criteria: The presence of any of the following will preclude participant inclusion: * Known or suspected secondary hypertension * Hypersensitivity to any of the study drugs or excipients * Currently taking drugs likely to have interactions with tirzepatide * Diagnosis of type 1 or type 2 diabetes mellitus or current usage of insulin or other injectable drugs for the treatment of diabetes such as but not limited to GLP-1 and GIP receptor agonists * Prior or planned surgical, endoscopic and/or device-based therapy treatment for obesity * Self-reported, intentional or unintentional, change in body weight (over \~10%) within \~three months of screening * Known heart failure or clinically significant valvular heart disease * Implanted pacemaker or implantable cardioverter defibrillator (ICD) * Second or third-degree AV block, sino-atrial block, sick sinus syndrome * Known active malignancy including thyroid cancer * Known renal impairment (creatinine \>150µmol/L) * Clinically significant neurological disease * History of scleroderma * Participants on anticoagulant therapy * Known history of pancreatitis * Known inflammatory bowel disease * History of gallstones (unless previous cholecystectomy) * Severe gastroparesis or gastric emptying abnormality * Family history of multiple endocrine neoplasia * Needle-phobia * Planned pregnancy, current pregnancy, or breastfeeding * Current involvement in the active treatment phase of other research studies * Any other clinical reason which may preclude entry in the opinion of the investigator