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Can a special workout change your muscles at the cellular level?

NCT ID NCT07341711

Knowledge-focused Sponsor: University of Thessaly Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how a six-month hybrid training program (combining cardio and strength exercises) affects muscle cells in 30 overweight or obese adults. Researchers will measure changes in mitochondria, blood vessels, and other muscle components. The goal is to understand the molecular benefits of this type of exercise, not to test a new medicine.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hybrid high-intensity interval training (HIIT) exercise program
What this could lead to
If successful, this could reveal how hybrid exercise improves muscle health at a cellular level, pointing toward better exercise programs for weight management.
What could go wrong
This is a small, early-stage observational study with only 30 participants. It does not test a new drug or treatment, so direct health benefits are not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI: \>25 kg/m2 and \<40 kg/m2 * Untrained individuals (abstain \>1 year from exercise training) * No dietary intervention over the last 6 months preceding the study * Low cardiorespiratory fitness level (VO2max: \<45 ml/kg/min) * No use of any medication, dietary supplements * Low risk for cardiovascular disease * A weight loss \<10% over the last 6 months preceding the study * Free of non-communicable diseases (excluding metabolic syndrome) Exclusion Criteria: * Low participation rate (\<80% completion of the exercise training sessions) * Unbalanced diet * Participation in additional exercise training regimes * Cosumption of anti-inflammatory of pain relief medication

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity & overweight

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Physical Education and Sport Science Trikala, University of Thessaly

    RECRUITING

    Trikala, Thessaly, 42100, Greece

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