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Do Pre-Pregnancy Weight-Loss drugs change pregnancy outcomes?

NCT ID NCT07743567

Knowledge-focused Sponsor: University of Kansas Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study looks at whether taking GLP-1 weight-loss medications before pregnancy influences how much weight a woman gains during pregnancy and her pregnancy outcomes. Researchers will compare pregnant women who used these medications before conception with those who did not. Participants will fill out questionnaires during and after pregnancy about their medication history and feelings around food. The goal is to gather information that could help guide future recommendations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
GLP-1 receptor agonist (GLP-1RA) medications used for weight loss before pregnancy
What this could lead to
If this study finds a link, it could help doctors guide women on using GLP-1 weight-loss medications before pregnancy, potentially improving maternal and infant health.
What could go wrong
This is an observational study, so it can't prove cause and effect. Other factors may explain any differences seen, and the results may not apply to all women.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women being seen at The University of Kansas Health System for an initial prenatal visit.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult women * Less than or equal to 20 weeks gestation at first visit * English speaking Exclusion Criteria: * \<18 years at time of initial visit * Type 2 diabetes * History of bariatric surgery * Multiple gestation * Cannot consent for themselves * Cannot read and speak English * Incarcerated

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Conditions

The condition(s) this trial relates to.

Gestational Weight Gain Obesity obesity disorder Overweight Pregnancy in Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gestational weight gain Obesity & overweight Pregnant individuals

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Kansas, 66160, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.