Could a Mitochondria-Targeting pill ease asthma in obesity?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: 1. participant reported physician diagnosis of asthma 2. participant reported on regular prescribed controller therapy for at least 3 months 3. positive methacholine challenge (as determined by spirometry PD20 or oscillometry PD50 ≤ 4.0 mg/ml at visit 2) 4. age: ≥18 years 5. BMI ≥ 30 kg/m2 (at visit 1) 6. poorly controlled asthma defined as one of the following: 1. Asthma Control Test5 Score ≤ 19 (at visit 1), or 2. Participant reported use of rescue inhaler on average \> 2 uses/week for preceding month, or 3. Participant reported nocturnal asthma awakening on average 1 or more times / week in preceding month, or 4. Participant reported ED/hospital visit or prednisone course for asthma in past six months 7. ability and willingness to provide informed consent Exclusion criteria: 1. participant reported use of an investigational agent in the prior 30 days 2. participant reported physician diagnosis of chronic obstructive pulmonary disease 3. pregnancy and/or participant reported lactation 4. females of childbearing age who do not agree to practice an adequate birth control method for the duration of the study (abstinence, combination barrier and spermicide, or hormonal) 5. participant reported greater than 10 pack year smoking history 6. participant reported smoking conventional tobacco products (cigar, cigarette, \& pipes) within the last 6 months 7. participant reported e-cigarette use more than 2x/week 8. participant unwilling to withhold e-cigarette use for the duration of the study 9. participant reported vaping more than 2x/week 10. participant unwilling to withhold vaping for the duration of the study 11. participant reported marijuana use (inhalation) more than 2x/week 12. participant unwilling to withhold marijuana use (inhalation) for the duration of the study 13. participant reported sinus surgery performed ≤ 4 weeks from visit 1 14. participant reported eye surgery within the prior 3 months 15. participant reported use of the antioxidants idebenone or co-enzyme Q10 within 8 weeks 16. participant reported tendency to develop severe nose bleeds 17. FEV1 ˂ 60% predicted or \< 1.5 Liters at visit 1 18. participant reported treatment for asthma exacerbation in the previous 4 weeks 19. participant was not able to complete at least 50% of the days on the diary cards returned at visit 2 20. other significant disease that in the opinion of the investigator would interfere with the study