Study reveals which diet keeps you burning calories after shedding pounds
NCT ID NCT02068885
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how different diet compositions affect the number of calories people burn and their risk for chronic diseases like diabetes and heart disease after losing weight. Over 200 adults with overweight or obesity followed a weight-loss phase, then a weight-maintenance phase, and finally an unrestricted eating phase. Researchers measured total and resting energy expenditure using special tracer methods and respiratory gas exchange.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify which diet composition best supports weight-loss maintenance and reduces risks for obesity-related diseases like diabetes and heart disease.
- What could go wrong
- This is an observational feeding study, not a treatment trial. Results may not apply to everyone, and dietary effects can vary widely among individuals.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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234 people
The number who actually took part.
- Started
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Aug 2014
- Finished
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May 2017
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged 18 to 65 years * BMI ≥ 25 kg/m2 * Weight ≤ 425 lbs * Medical clearance from a primary care provider * Plans to matriculate at Framingham State University (campus-based participants: students), work on campus (campus-based participants: faculty and staff), or live in the greater Framingham area (community-based participants) throughout the academic year of enrollment in the study * Academic and social clearance from the FSU Office of Enrollment and Student Development (student participants) or willingness to comply with Criminal Offender Record Information (CORI) check and Sex Offender Registry Information (SORI) check (community-based subjects) * Willingness to eat and drink only the foods and beverages on the study menus during participation, with no food allergies or aversions * Willingness to eat in the dining hall * Willingness to abstain from consuming alcohol during participation Exclusion Criteria: * Change in body weight exceeding ±10% during prior year * Recent adherence to a special diet * Recent adherence to a vigorous physical activity regimen (e.g., participation in a varsity sport) * Chronic use of any medication or dietary supplement that could affect study outcomes * Current smoking (1 cigarette in the last week) * Heavy baseline alcohol consumption (\> 10 drinks/week) or history of binge drinking (≥ 5 drinks in 1 day, anytime in past 6 months) * Physician diagnosis of a major medical/psychiatric illness or eating disorder * Abnormal HgA1c, TSH, BUN, creatinine; hematocrit \< 30; ALT \> 200% of normal upper limit * Plans for a vacation during the study that would preclude adherence to prescribed diet * Additional exclusions for female participants: Irregular menstrual cycles; any change in birth control medication during the 3 months prior to enrollment; pregnancy or lactation during the 12 months prior to enrollment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Framingham State University
Framingham, Massachusetts, 01702, United States
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