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Fat tissue differences may explain why diabetes hits some ethnic groups harder

NCT ID NCT07666321

Knowledge-focused Sponsor: University of Roehampton Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This completed pilot study examined how fat tissue dysfunction contributes to type 2 diabetes risk in overweight men from South Asian, Black African/Caribbean, and White European backgrounds. Researchers used MRI scans and blood tests to measure fat distribution, inflammation, and glucose metabolism. The goal was to uncover why diabetes rates are higher in certain ethnic groups and to inform future prevention efforts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help explain why some ethnic groups are more prone to type 2 diabetes, leading to better prevention strategies tailored to different populations.
What could go wrong
This is a small pilot study with only 39 participants, so findings may not apply to everyone. It is observational and does not test a treatment, so it won't directly lead to a new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

39 people

The number who actually took part.

Started

Jan 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Healthy Male * Aged 18-65 years * Self-identify as one of the following ethnic groups: * Black African/Caribbean * South Asian * White European

Ages

18 to 65 years

Sex

Male participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male * Aged 18-65 years * Self-identify as one of the following ethnic groups: Black African/Caribbean South Asian White European * Self-reported ancestry from the same ethnic background for at least three generations * Body Mass Index (BMI) ≥25 kg/m² and ≤40 kg/m² * Overweight or obese but otherwise generally healthy * Generally healthy, with no serious long-term medical conditions or taking medications that may alter body fat distribution * Residing in the United Kingdom * Able to understand written and spoken English * Able and willing to provide written informed consent * Willing and able to comply with all study procedures, including: * Screening assessments * Oral Glucose Tolerance Test (OGTT) * Blood sampling * Magnetic Resonance Imaging (MRI) Exclusion Criteria: * Previous diagnosis of type 1 diabetes mellitus or type 2 diabetes mellitus * HbA1c values within the diabetic range at screening * Body Mass Index (BMI) \<25 kg/m² * Presence of chronic medical conditions known to affect: * glucose metabolism * insulin sensitivity * adipose tissue distribution * inflammatory or metabolic status * History of cardiovascular, hepatic, renal, endocrine, or metabolic disease that may interfere with study outcomes or participant safety * Current use of medications known to influence: * glucose metabolism * insulin sensitivity * lipid metabolism * body composition * Current use of corticosteroids or other medications affecting metabolic function * history of substance or alcohol misuse * Contraindications to MRI, including: * metallic implants * pacemakers * severe claustrophobia * Inability to undergo venepuncture or cannulation procedures safely * Participation in another clinical or interventional research study within the previous 3 months * Inability or unwillingness to comply with study procedures or provide informed consent

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adiposity

Contacts and locations

Locations

  • Adele Costabile

    London, SW145JD, United Kingdom

  • University of Roehampton, School of Life and Health Sciences

    London, UK, SW15 4JD, United Kingdom

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