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Study to uncover how body fat and insulin resistance shape your food cravings

NCT ID NCT07638059

Knowledge-focused Sponsor: Virginia Polytechnic Institute and State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 26, 2026 · Updated 2 times

Summary

This study looks at how having extra body fat and being resistant to insulin can change the way your brain learns to like or want certain foods. Researchers will give 50 adults flavored drinks with sweetener, sometimes with extra calories, to see how their preferences shift. The goal is to better understand why some people may struggle with food choices, which could lead to better ways to support healthy eating.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 to 45 years of age * Self-reported weight stable (within 5 lbs) for previous 3 months * Not pregnant or planning to become pregnant during study participation * Weigh more than 110 lbs (due to blood draws used in study) * Residing in Roanoke, VA, area and/or willing to attend sessions at the Fralin Biomedical Research Institute Exclusion criteria: * BMI \< 18.5 or \> 40 kg/m2 * Hemoglobin A1c \> 6.4% * Fasting blood glucose \> 126 mg/dL * 2-hour blood glucose \> 200 mg/dL * Self-reported current diagnosis of diabetes or other endocrine/metabolic disorder * Self-reported current inhaled nicotine use * Self-reported history of alcohol dependence * Self-reported use of medications known to influence study measures (including antiglycemic agents, thyroid medications, etc.) * Self-reported neurological or psychological disorder * Self-reported claustrophobia or discomfort with mock fMRI training * Self-reported history of head injury resulting in loss of consciousness for more than 10 minutes * Contraindications to MRI, including pacemaker, aneurysm clip, neurostimulator, cochlear implant, metal in eyes, steel worker, other implants * Self-reported previous metabolic/weight loss surgery * Self-reported adherence to special or restrictive diet within the past 3 months (e.g., low-carb, ketogenic, exclusion of food groups/specific macronutrients, etc.) * Self-reported allergy to ingredient used in the study drinks

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Adiposity Decision making Insulin sensitivity/resistance Reward learning

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

More trials for these conditions

Other studies related to the condition(s) this trial covers.